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Protein Overview: P63_RAT

General Information:
Name(s) found: P63_RAT [Swiss-Prot]
Description(s) found:
Found 21 descriptions.
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  • Tumor protein 63 OS=Rattus norvegicus GN=Tp63 PE=2 SV=1 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 680 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN][IDA]
    dendrite [IDA]
    cytoplasm [UNKNOWN]
    rough microsome [IDA]
    protein complex [IDA]
    neuron projection [IDA]
    Biological Process: tail morphogenesis [UNKNOWN]
    epidermis development [UNKNOWN]
    ectoderm and mesoderm interaction [UNKNOWN]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [UNKNOWN]
    epithelial cell development [UNKNOWN]
    odontogenesis of dentine-containing tooth [UNKNOWN]
    skin morphogenesis [UNKNOWN]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    replicative cell aging [IMP]
    positive regulation of Notch signaling pathway [UNKNOWN]
    proximal/distal pattern formation [UNKNOWN]
    negative regulation of transcription from RNA polymerase II promoter [UNKNOWN]
    sympathetic nervous system development [UNKNOWN]
    embryonic limb morphogenesis [UNKNOWN]
    skeletal system development [UNKNOWN]
    protein homotetramerization [UNKNOWN]
    hair follicle development [UNKNOWN]
    anti-apoptosis [UNKNOWN]
    negative regulation of transcription, DNA-dependent [UNKNOWN]
    squamous basal epithelial stem cell differentiation involved in prostate gland acinus development [UNKNOWN]
    induction of apoptosis [UNKNOWN]
    positive regulation of transcription, DNA-dependent [UNKNOWN]
    apoptosis [UNKNOWN]
    multicellular organismal aging [UNKNOWN]
    neuron apoptosis [UNKNOWN]
    female genitalia morphogenesis [UNKNOWN]
    keratinocyte proliferation [UNKNOWN]
    negative regulation of keratinocyte differentiation [UNKNOWN]
    urinary bladder development [UNKNOWN]
    spermatogenesis [IEP]
    cloacal septation [UNKNOWN]
    pattern specification process [UNKNOWN]
    anatomical structure formation involved in morphogenesis [UNKNOWN]
    smooth muscle tissue development [UNKNOWN]
    positive regulation of mesenchymal cell proliferation [UNKNOWN]
    cell aging [UNKNOWN]
    organ morphogenesis [UNKNOWN]
    prostatic bud formation [UNKNOWN]
    epithelial cell differentiation [UNKNOWN]
    keratinocyte differentiation [UNKNOWN]
    polarized epithelial cell differentiation [UNKNOWN]
    establishment of planar polarity [UNKNOWN]
    cell differentiation [UNKNOWN]
    morphogenesis of a polarized epithelium [UNKNOWN]
    hair follicle morphogenesis [UNKNOWN]
    prostate gland development [UNKNOWN]
    Molecular Function: DNA binding [UNKNOWN]
    transcription factor activity [IDA]
    protein domain specific binding [IPI]
    identical protein binding [UNKNOWN]
    protein binding [UNKNOWN][IPI]
    double-stranded DNA binding [IDA]
    sequence-specific DNA binding [UNKNOWN]
    chromatin binding [UNKNOWN]
    transcription activator activity [UNKNOWN]
    transcription repressor activity [UNKNOWN]
    damaged DNA binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFETSRCAT LQYCPDPYIQ RFIETPSHFS WKESYYRSAM SQSTQTSEFL SPEVFQHIWD  60
   61 FLEQPICSVQ PIDLNFVDEP SENGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNGM 120
  121 DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 180
  181 FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 240
  241 VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 300
  301 TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 360
  361 KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 420
  421 LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ 480
  481 LINPQQRNAL TPTTMPEGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 540
  541 PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 600
  601 ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 660
  661 FNFDMDSRRN KQQRIKEEGE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle