Protein Overview: MK01_RAT

General Information:
Name(s) found:	MK01_RAT [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|52001075\|sp\|P63086.3\|MK01_RAT RecName: Full=Mitogen-activated protein kinase 1; AltName: Full=Extracellular signal-regulated kinase 2; Short=ERK-2; AltName: Full=Mitogen-activated protein kinase 2; Short=MAP kinase 2; Short=MAPK 2; AltName: Full=p42-MA [NCBI NR] gi\|204056\|gb\|AAA41124.1\| extracellular signal-related kinase 2 [NCBI NR] gi\|16758698\|ref\|NP_446294.1\| mitogen-activated protein kinase 1 [Rattus norvegicus] [NCBI NR] gi\|149019720\|gb\|EDL77868.1\| mitogen activated protein kinase 1 [Rattus norvegicus] [NCBI NR] pir\|\|A40033 protein kinase (EC 2.7.1.37) ERK2 - rat [NCBI NR] Mitogen-activated protein kinase 1 OS=Rattus norvegicus GN=Mapk1 PE=1 SV=3 [Swiss-Prot] Ensembl_locations(Chr-bp):11-1593541 Mitogen-activated protein kinase 1 [hmr_yeast5_DM3-1_pombe.fasta] mitogen activated protein kinase 1; extracellular-signal-regulated kinase 1 [HMR_022704-rand.fasta] mitogen activated protein kinase 1 [Mus musculus]gi\|16758698\|ref\|NP_446294.1\| mitogen activated protein kinase 1 [Rattus norvegicus]gi\|34849482\|gb\|AAH58258.1\| Mitogen activated protein kinase 1 [Mus musculus]gi\|286076\|dbj\|BAA01733.1\| ERK2 [Mus musculus [nrdb_11152004_Chlamydomonas] Tax_Id=10116 Mitogen-activated protein kinase 1 [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta] (NM_053842) mitogen activated protein kinase 1 [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] mitogen activated protein kinase 1 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Mitogen-activated protein kinase 1 (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) (p42-MAPK) (ERT1) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] extracellular signal-related kinase 2 [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10116 MITOGEN-ACTIVATED PROTEIN KINASE 1 [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10116 Gene_Symbol=Mapk1 Mitogen-activated protein kinase 1 [rat-ipi-250309-contam.fasta] Mitogen-activated protein kinase 1 OS=Rattus norvegicus GN=Mapk1 [011711_HMR.fasta]
Organism:	Rattus norvegicus
Length:	358 amino acids
Gene Ontology:
Cellular Component:	microtubule cytoskeleton [UNKNOWN] protein complex [IDA] [NOT]nucleolus [UNKNOWN] perikaryon [IDA] nucleoplasm [UNKNOWN][IDA] nucleus [UNKNOWN][IDA] insoluble fraction [IDA] soluble fraction [IDA] cytoskeleton [IEA] cytoplasm [UNKNOWN][IEA] dendrite cytoplasm [IDA] cytosol [UNKNOWN][IDA] axon part [IDA]
Biological Process:	cytosine metabolic process [UNKNOWN][IEA] response to estrogen stimulus [IDA] positive regulation of translation [IMP] positive regulation of cell proliferation [IEP] positive regulation of transcription [IEP] protein amino acid phosphorylation [UNKNOWN][IDA][IEA][TAS] response to toxin [IDA] MAPKKK cascade [UNKNOWN][IMP] negative regulation of cell differentiation [UNKNOWN][IEA] response to exogenous dsRNA [UNKNOWN][IEA] T cell receptor signaling pathway [UNKNOWN][IEA] B cell receptor signaling pathway [UNKNOWN][IEA] signal transduction [IDA] small GTPase mediated signal transduction [UNKNOWN] response to chemical stimulus [IDA] intracellular protein kinase cascade [TAS] Ras protein signal transduction [UNKNOWN] response to DNA damage stimulus [UNKNOWN][IEA] cell cycle [IEA] nuclear translocation of MAPK [IDA] organ morphogenesis [UNKNOWN][IEA] intracellular signaling pathway [IDA] labyrinthine layer blood vessel development [UNKNOWN][IEA] sensory perception of pain [IMP] lipopolysaccharide-mediated signaling pathway [UNKNOWN][IEA] response to lipopolysaccharide [UNKNOWN][IEA] positive regulation of cell migration [IEP]
Molecular Function:	RNA polymerase II carboxy-terminal domain kinase activity [IEA] protein kinase activity [UNKNOWN] MAP kinase 2 activity [UNKNOWN][IEA] transcription factor binding [IPI] protein serine/threonine kinase activity [IC][UNKNOWN][IDA][IEA] nucleotide binding [IEA] phosphotyrosine binding [UNKNOWN][IEA] ATP binding [IDA][IEA] protein binding [UNKNOWN][IDA][IPI] MAP kinase activity [UNKNOWN][IDA][IEA][TAS] transferase activity [IEA] mitogen-activated protein kinase kinase kinase binding [IPI] kinase activity [UNKNOWN][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ  60
   61 TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS 120
  121 NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG 180
  181 FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG 240
  241 ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI 300
  301 EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: MK01_RAT

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: