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Protein Overview: MK01_RAT

General Information:
Name(s) found: MK01_RAT [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Mitogen-activated protein kinase 1 OS=Rattus norvegicus GN=Mapk1 PE=1 SV=3 [Swiss-Prot]
    • Organism: Rattus norvegicus
    Length: 358 amino acids

    Gene Ontology:
    Cellular Component: microtubule cytoskeleton [UNKNOWN]
    protein complex [IDA]
    [NOT]nucleolus [UNKNOWN]
    perikaryon [IDA]
    nucleoplasm [UNKNOWN][IDA]
    nucleus [UNKNOWN][IDA]
    insoluble fraction [IDA]
    soluble fraction [IDA]
    cytoskeleton [IEA]
    cytoplasm [UNKNOWN][IEA]
    dendrite cytoplasm [IDA]
    cytosol [UNKNOWN][IDA]
    axon part [IDA]
    Biological Process: cytosine metabolic process [UNKNOWN][IEA]
    response to estrogen stimulus [IDA]
    positive regulation of translation [IMP]
    positive regulation of cell proliferation [IEP]
    positive regulation of transcription [IEP]
    protein amino acid phosphorylation [UNKNOWN][IDA][IEA][TAS]
    response to toxin [IDA]
    MAPKKK cascade [UNKNOWN][IMP]
    negative regulation of cell differentiation [UNKNOWN][IEA]
    response to exogenous dsRNA [UNKNOWN][IEA]
    T cell receptor signaling pathway [UNKNOWN][IEA]
    B cell receptor signaling pathway [UNKNOWN][IEA]
    signal transduction [IDA]
    small GTPase mediated signal transduction [UNKNOWN]
    response to chemical stimulus [IDA]
    intracellular protein kinase cascade [TAS]
    Ras protein signal transduction [UNKNOWN]
    response to DNA damage stimulus [UNKNOWN][IEA]
    cell cycle [IEA]
    nuclear translocation of MAPK [IDA]
    organ morphogenesis [UNKNOWN][IEA]
    intracellular signaling pathway [IDA]
    labyrinthine layer blood vessel development [UNKNOWN][IEA]
    sensory perception of pain [IMP]
    lipopolysaccharide-mediated signaling pathway [UNKNOWN][IEA]
    response to lipopolysaccharide [UNKNOWN][IEA]
    positive regulation of cell migration [IEP]
    Molecular Function: RNA polymerase II carboxy-terminal domain kinase activity [IEA]
    protein kinase activity [UNKNOWN]
    MAP kinase 2 activity [UNKNOWN][IEA]
    transcription factor binding [IPI]
    protein serine/threonine kinase activity [IC][UNKNOWN][IDA][IEA]
    nucleotide binding [IEA]
    phosphotyrosine binding [UNKNOWN][IEA]
    ATP binding [IDA][IEA]
    protein binding [UNKNOWN][IDA][IPI]
    MAP kinase activity [UNKNOWN][IDA][IEA][TAS]
    transferase activity [IEA]
    mitogen-activated protein kinase kinase kinase binding [IPI]
    kinase activity [UNKNOWN][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ  60
   61 TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS 120
  121 NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG 180
  181 FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG 240
  241 ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI 300
  301 EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle