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Protein Overview: PDX1_MOUSE

General Information:
Name(s) found: PDX1_MOUSE [Swiss-Prot]
Description(s) found:
Found 33 descriptions.
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  • Pancreas/duodenum homeobox protein 1 OS=Mus musculus GN=Pdx1 PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 284 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][UNKNOWN][IDA]
    cytoplasm [UNKNOWN]
    intracellular part [IDA]
    Biological Process: multicellular organismal development [IEA]
    negative regulation of cell proliferation [IMP]
    positive regulation of cell proliferation [UNKNOWN][IMP]
    transcription from RNA polymerase II promoter [UNKNOWN]
    positive regulation of transcription [UNKNOWN]
    protein heterooligomerization [UNKNOWN]
    positive regulation of DNA binding [UNKNOWN]
    glucose metabolic process [IDA]
    regulation of transcription [IEA]
    positive regulation of transcription from RNA polymerase II promoter [UNKNOWN][IDA]
    negative regulation of transcription from RNA polymerase II promoter [IDA]
    response to glucose stimulus [UNKNOWN]
    stem cell differentiation [UNKNOWN]
    morphogenesis of embryonic epithelium [IMP]
    positive regulation of insulin secretion [UNKNOWN]
    exocrine pancreas development [IMP]
    endocrine pancreas development [IMP]
    pancreas development [IMP]
    transcription [IEA]
    transcription, DNA-dependent [UNKNOWN]
    smoothened signaling pathway [UNKNOWN]
    regulation of transcription, DNA-dependent [IDA]
    regulation of cell proliferation [IDA]
    regulation of transcription from RNA polymerase II promoter [IMP]
    negative regulation of transcription [UNKNOWN]
    glucose homeostasis [UNKNOWN][IMP]
    cell differentiation [UNKNOWN][IMP]
    positive regulation of cell death [UNKNOWN]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [UNKNOWN][IDA]
    protein binding [IPI]
    protein homodimerization activity [UNKNOWN]
    RNA polymerase II transcription factor activity [IDA]
    transcription regulator activity [IEA]
    protein heterodimerization activity [UNKNOWN]
    sequence-specific DNA binding [UNKNOWN][IDA]
    transcription factor binding [UNKNOWN]
    transcription activator activity [UNKNOWN][IDA]
    promoter binding [UNKNOWN]
    protein complex binding [UNKNOWN]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSEEQYYAA TQLYKDPCAF QRGPVPEFSA NPPACLYMGR QPPPPPPPQF TSSLGSLEQG  60
   61 SPPDISPYEV PPLASDDPAG AHLHHHLPAQ LGLAHPPPGP FPNGTEPGGL EEPNRVQLPF 120
  121 PWMKSTKAHA WKGQWAGGAY TAEPEENKRT RTAYTRAQLL ELEKEFLFNK YISRPRRVEL 180
  181 AVMLNLTERH IKIWFQNRRM KWKKEEDKKR SSGTPSGGGG GEEPEQDCAV TSGEELLAVP 240
  241 PLPPPGGAVP PGVPAAVREG LLPSGLSVSP QPSSIAPLRP QEPR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..125] MSA 2.179996 View MSA. No confident structure predictions are available.
    2 View Details [126..284] PSI-BLAST 26.69897 No description for 2h1kA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle