Protein Overview: CASP3_MOUSE

General Information:
Name(s) found:	CASP3_MOUSE [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|6753284\|ref\|NP_033940.1\| caspase 3 [Mus musculus] [NCBI NR] gi\|37572246\|gb\|AAH38825.2\| Caspase 3 [Mus musculus] [NCBI NR] gi\|2493527\|sp\|P70677.1\|CASP3_MOUSE RecName: Full=Caspase-3; Short=CASP-3; AltName: Full=Apopain; AltName: Full=Cysteine protease CPP32; Short=CPP-32; AltName: Full=Yama protein; AltName: Full=SREBP cleavage activity 1; Short=SCA-1; AltName: Full=LICE; Con [NCBI NR] gi\|2317650\|dbj\|BAA21727.1\| CPP32 [Mus musculus] [NCBI NR] gi\|2114328\|gb\|AAC53196.1\| CPP32 [Mus musculus] [NCBI NR] gi\|2094810\|emb\|CAA73528.1\| caspase-3 [Mus musculus] [NCBI NR] gi\|1518968\|gb\|AAC52768.1\| cysteine protease [NCBI NR] gi\|1518934\|gb\|AAC52764.1\| ICE-like cysteine protease [NCBI NR] gi\|148703635\|gb\|EDL35582.1\| caspase 3, isoform CRA_a [Mus musculus] [NCBI NR] gi\|148703630\|gb\|EDL35577.1\| caspase 3, isoform CRA_a [Mus musculus] [NCBI NR] (P70677) Caspase-3 precursor (EC 3.4.22.-) (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Swiss-Prot] Caspase-3 OS=Mus musculus GN=Casp3 PE=1 SV=1 [Swiss-Prot] Ensembl_locations(Chr-bp):8-45637659 Apopain precursor [hmr_yeast5_DM3-1_pombe.fasta] caspase 3, apoptosis related cysteine protease [HMR_022704-rand.fasta] Caspase-3 precursor [ipi.MOUSE.v3.06.fasta] caspase 3, apoptosis related cysteine protease [Mus musculus]gi\|37572246\|gb\|AAH38825.2\| Caspase 3, apoptosis related cysteine protease [Mus musculus]gi\|2114328\|gb\|AAC53196.1\| CPP32 [Mus musculus]gi\|1518968\|gb\|AAC52768.1\| cysteine proteasegi\|1518934\|gb [nrdb_11152004_Chlamydomonas] Tax_Id=10090 Caspase-3 precursor [EBI-IPI_mouse_3.17_05-10-2006_con_reversed.fasta] (NM_009810) caspase 3, apoptosis related cysteine protease [Mus musculus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta] caspase 3, apoptosis related cysteine protease [Mus musculus] [mouse-NCBI-010306_contam_rand.fasta] caspase 3 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32) (CPP-32) (Yama protein) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 subunit p17; Caspase-3 subunit p12] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] CPP32 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] caspase 3, isoform CRA_a [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Caspase 3 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] caspase-3 [Mus musculus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] cysteine protease [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] ICE-like cysteine protease [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta] Tax_Id=10090 CASPASE-3 PRECURSOR [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta] Tax_Id=10090 Gene_Symbol=Casp3 Caspase-3 [mouse-ipi-250309-contam.fasta] Tax_Id=10090 Gene_Symbol=Casp3 Caspase-3 precursor [ipi.MOUSE_jw_12may08.contam.fasta] Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32) (Yama protein) (CPP-32) (SREBP cleavage activity 1) (SCA-1) (LICE) [Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit] [nr-271106-contam.fasta] Tax_Id=10090 Gene_Symbol=Casp3 Caspase-3 precursor ENSMUSG00000031628 IPI00308498 [IPIxENS.MOUSE_plus_REVERSE.fasta] IPI:IPI00308498.1\|SWISS-PROT:P70677\|TREMBL:Q8BNT4\|ENSEMBL:ENSMUSP00000091238\|REFSEQ:NP_033940 Tax_Id=10090 Gene_Symbol=Casp3 Caspase-3 [ipi.MOUSE.fasta.20090209] Caspase-3 OS=Mus musculus GN=Casp3 [011711_HMR.fasta] sp\|P70677\|CASP3_MOUSE Caspase-3 OS=Mus musculus GN=Casp3 PE=1 SV=1 [uniprot.sptr.mouse.20130102]
Organism:	Mus musculus
Length:	277 amino acids
Gene Ontology:
Cellular Component:	soluble fraction [UNKNOWN] cytoplasm [IDA] cytosol [UNKNOWN]
Biological Process:	negative regulation of cell cycle [IMP] response to wounding [IDA] response to UV [IDA][IGI] induction of apoptosis via death domain receptors [IMP] positive regulation of neuron apoptosis [UNKNOWN] T cell homeostasis [IMP] learning or memory [UNKNOWN] sensory perception of sound [IMP] heart development [IGI] response to glucose stimulus [UNKNOWN] negative regulation of B cell proliferation [IMP] induction of apoptosis [IDA][IGI][IMP][RCA] apoptosis [UNKNOWN][IDA][IGI][IMP] neuron apoptosis [IDA] induction of apoptosis by oxidative stress [IDA] negative regulation of activated T cell proliferation [IMP] response to hydrogen peroxide [UNKNOWN] response to DNA damage stimulus [IDA] negative regulation of cyclin-dependent protein kinase activity [IMP] B cell homeostasis [IMP] keratinocyte differentiation [IMP] intracellular signaling pathway [UNKNOWN] DNA fragmentation involved in apoptosis [IMP] negative regulation of apoptosis [UNKNOWN] proteolysis [UNKNOWN][RCA] cell fate commitment [IMP] positive regulation of apoptosis [UNKNOWN] release of cytochrome c from mitochondria [IGI]
Molecular Function:	protein binding [IPI] cysteine-type endopeptidase activity [IEA] cysteine-type peptidase activity [UNKNOWN][IDA] peptidase activity [UNKNOWN][IDA][IMP][RCA] cyclin-dependent protein kinase inhibitor activity [IMP] phospholipase A2 activator activity [UNKNOWN] hydrolase activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENNKTSVDS KSINNFEVKT IHGSKSVDSG IYLDSSYKMD YPEMGICIII NNKNFHKSTG  60
   61 MSSRSGTDVD AANLRETFMG LKYQVRNKND LTREDILELM DSVSKEDHSK RSSFVCVILS 120
  121 HGDEGVIYGT NGPVELKKLT SFFRGDYCRS LTGKPKLFII QACRGTELDC GIETDSGTDE 180
  181 EMACQKIPVE ADFLYAYSTA PGYYSWRNSK DGSWFIQSLC SMLKLYAHKL EFMHILTRVN 240
  241 RKVATEFESF SLDSTFHAKK QIPCIVSMLT KELYFYH

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..277]	PSI-BLAST	102.0	Apopain (caspase-3, cpp32)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: CASP3_MOUSE

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: