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Protein Overview: gi|55957392, gi|...

General Information:
Name(s) found: gi|84105520 [NCBI NR]
gi|55957392 [NCBI NR]
gi|55664644 [NCBI NR]
gi|1944185 [NCBI NR]
gi|119570002 [NCBI NR]
gi|119570001 [NCBI NR]
Description(s) found:
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  • gi|84105520|gb|AAI11566.1| SLK protein [Homo sapiens] [NCBI NR]
  • gi|55957392|emb|CAI12396.1| Ste20-related serine\/threonine kinase (SLK) [Homo sapiens] [NCBI NR]
  • gi|55664644|emb|CAH70403.1| Ste20-related serine\/threonine kinase (SLK) [Homo sapiens] [NCBI NR]
  • gi|1944185|dbj|BAA19655.1| hSLK [Homo sapiens] [NCBI NR]
  • gi|119570002|gb|EAW49617.1| STE20-like kinase (yeast), isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119570001|gb|EAW49616.1| STE20-like kinase (yeast), isoform CRA_b [Homo sapiens] [NCBI NR]
  • HSLK [hmr_yeast5_DM3-1_pombe.fasta]
  • Ste20-related serine\/threonine kinase (SLK) [Homo sapiens]gi|1944185|dbj|BAA19655.1| hSLK [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Splice Isoform 2 of STE20-like serine/threonine-protein kinase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • Tax_Id=9606 Ste20-related serine/threonine kinase; Ste20-like kinase [EBI-IPI_human_3.12_11-03-2005_con_reversed.fasta]
  • hSLK [Homo sapiens] [NCBI-RefSeq_human_na_05-03-2007_con_reversed.fasta]
  • Ste20-related serine\/threonine kinase (SLK) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • STE20-like kinase (yeast), isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • SLK protein [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 2 of STE20-like serine/threonine-protein kinase [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 HSLK [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=SLK Isoform 2 of STE20-like serine/threonine-protein kinase [human-ipi-250309-contam.fasta]
  • IPI:IPI00247439.3|SWISS-PROT:Q9H2G2-2|TREMBL:B4DZC9|ENSEMBL:ENSP00000336824|VEGA:OTTHUMP00000020425 Tax_Id=9606 Gene_Symbol=SLK Isoform 2 of STE20-like serine/threonine-protein kinase [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Isoform 2 of STE20-like serine/threonine-protein kinase OS=Homo sapiens GN=SLK [011711_HMR.fasta]
  • IPI:IPI00247439.3|SWISS-PROT:Q9H2G2-2|TREMBL:B4DZC9;D3DRA1|ENSEMBL:ENSP00000336824|VEGA:OTTHUMP00000020425 Tax_Id=9606 Gene_Symbol=SLK Isoform 2 of STE20-like serine/threonine-protein kinase [ipi.HUMAN.fasta.20100406]
  • Isoform 2 of STE20-like serine/threonine-protein kinase GN=SLK [Doctor+uniprot-HUMAN-120911.fasta]
  • Isoform of Q9H2G2, Isoform 2 of STE20-like serine/threonine-protein kinase OS=Homo sapiens GN=SLK [2016-04-human-contam-aPKC-His-Par6.fasta]
    • Organism: Homo sapiens
    Length: 1204 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFNFRKIF KLGSEKKKKQ YEHVKRDLNP EDFWEIIGEL GDGAFGKVYK AQNKETSVLA  60
   61 AAKVIDTKSE EELEDYMVEI DILASCDHPN IVKLLDAFYY ENNLWILIEF CAGGAVDAVM 120
  121 LELERPLTES QIQVVCKQTL DALNYLHDNK IIHRDLKAGN ILFTLDGDIK LADFGVSAKN 180
  181 TRTIQRRDSF IGTPYWMAPE VVMCETSKDR PYDYKADVWS LGITLIEMAE IEPPHHELNP 240
  241 MRVLLKIAKS EPPTLAQPSR WSSNFKDFLK KCLEKNVDAR WTTSQLLQHP FVTVDSNKPI 300
  301 RELIAEAKAE VTEEVEDGKE EDEEEETENS LPIPASKRAS SDLSIASSEE DKLSQNACIL 360
  361 ESVSEKTERS NSEDKLNSKI LNEKPTTDEP EKAVEDINEH ITDAQLEAMT ELHDRTAVIK 420
  421 ENEREKRPKL ENLPDTEDQE TVDINSVSEG KENNIMITLE TNIEHNLKSE EEKDQEKQQM 480
  481 FENKLIKSEE IKDTILQTVD LVSQETGEKE ANIQAVDSEV GLTKEDTQEK LGEDDKTQKD 540
  541 VISNTSDVIG TCEAADVAQK VDEDSAEDTQ SNDGKEVVEV GQKLINKPMV GPEAGGTKEV 600
  601 PIKEIVEMNE IEEGKNKEQA INSSENIMDI NEEPGTTEGE EITESSSTEE MEVRSVVADT 660
  661 DQKALGSEVQ DASKVTTQID KEKKEIPVSI KKEPEVTVVS QPTEPQPVLI PSININSDSG 720
  721 ENKEEIGSLS KTETILPPES ENPKENDNDS GTGSTADTSS IDLNLSISSF LSKTKDSGSI 780
  781 SLQETRRQKK TLKKTRKFIV DGVEVSVTTS KIVTDSDSKT EELRFLRRQE LRELRFLQKE 840
  841 EQRAQQQLNS KLQQQREQIF RRFEQEMMSK KRQYDQEIEN LEKQQKQTIE RLEQEHTNRL 900
  901 RDEAKRIKGE QEKELSKFQN MLKNRKKEEQ EFVQKQQQEL DGSLKKIIQQ QKAELANIER 960
  961 ECLNNKQQLM RAREAAIWEL EERHLQEKHQ LLKQQLKDQY FMQRHQLLKR HEKETEQMQR1020
 1021 YNQRLIEELK NRQTQERARL PKIQRSEAKT RMAMFKKSLR INSTATPDQD RDKIKQFAAQ1080
 1081 EEKRQKNERM AQHQKHENQM RDLQLQCEAN VRELHQLQNE KCHLLVEHET QKLKELDEEH1140
 1141 SQELKEWREK LRPRKKTLEE EFARKLQEQE VFFKMTGESE CLNPSTQSRI SKFYPIPSLH1200
 1201 STGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..320] PSI-BLAST 60.09691 No description for 2j51A was found.
    2 View Details [321..407] deduced N/A No confident structure predictions are available.
    3 View Details [408..525] deduced N/A No confident structure predictions are available.
    4 View Details [526..600] deduced N/A No confident structure predictions are available.
    5 View Details [601..934] PSI-BLAST 15.0 Heavy meromyosin subfragment
    6 View Details [935..1001] PSI-BLAST 6.045757 Tropomyosin
    7 View Details [1002..1204] PSI-BLAST 4.69897 No description for 2dfsA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphotransferase activity, alcohol group as acceptor
    		•  5.49988294224815 bayes_pls_golite062009
  • protein kinase activity
    		•  5.4586557943719 bayes_pls_golite062009
  • kinase activity
    		•  5.3287080791198 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  4.96052051118534 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  4.62392503670521 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  4.46381887831481 bayes_pls_golite062009
  • transferase activity
    		•  3.97138602499442 bayes_pls_golite062009
  • phosphoinositide 3-kinase binding
    		•  2.79505438761262 bayes_pls_golite062009
  • binding
    		•  2.74863538127007 bayes_pls_golite062009
  • protein binding
    		•  2.276111749106 bayes_pls_golite062009
  • ATP binding
    		•  1.97600611746091 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.93596671856664 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.93176092222748 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.90928021591891 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.90354666768303 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.71452519680794 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.65732943334212 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.65726906484847 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.63763394711025 bayes_pls_golite062009
  • nucleotide binding
    		•  1.63195828048121 bayes_pls_golite062009
  • insulin receptor substrate binding
    		•  1.62657794525303 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.56748951434625 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.3898059094397 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  1.38496328649031 bayes_pls_golite062009
  • DNA binding
    		•  1.35333135345112 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.27291233344322 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.27184436658773 bayes_pls_golite062009
  • insulin receptor activity
    		•  1.22442673174261 bayes_pls_golite062009
  • catalytic activity
    		•  1.21655087018101 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.16049201286103 bayes_pls_golite062009
  • transcription factor activity
    		•  1.10928254946881 bayes_pls_golite062009
  • transcription activator activity
    		•  0.997272622653026 bayes_pls_golite062009
  • PTB domain binding
    		•  0.9900774724568 bayes_pls_golite062009
  • insulin-like growth factor receptor binding
    		•  0.872782211382796 bayes_pls_golite062009
  • insulin binding
    		•  0.614254468447749 bayes_pls_golite062009
  • transporter activity
    		•  0.595111702412257 bayes_pls_golite062009
  • protein serine/threonine/tyrosine kinase activity
    		•  0.48345772948903 bayes_pls_golite062009
  • protein kinase C activity
    		•  0.41587987561486 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.41384976209545 bayes_pls_golite062009
  • magnesium ion binding
    		•  0.393328812780268 bayes_pls_golite062009
  • telethonin binding
    		•  0.386946764759301 bayes_pls_golite062009
  • MAP kinase kinase kinase activity
    		•  0.37115026509016 bayes_pls_golite062009
  • MAP kinase kinase activity
    		•  0.35402045013148 bayes_pls_golite062009
  • protein complex binding
    		•  0.343240719858581 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.32649770094749 bayes_pls_golite062009
  • signal transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.270054246024761 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.266450215230107 bayes_pls_golite062009
  • MAP kinase activity
    		•  0.26024936404169 bayes_pls_golite062009
  • cation channel activity
    		•  0.245400615103891 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.226760162354251 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.214293154365587 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.0922946791401962 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.0556163711947139 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.00652065412910241 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0040394359628233 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle