Protein Overview: ASR1

General Information:
Name(s) found:	ASR1 / YPR093C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|81170375\|sp\|Q06834.2\|ASR1_YEAST RecName: Full=Alcohol-sensitive RING finger protein 1 [NCBI NR] gi\|37362706\|ref\|NP_015418.2\| Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain; Asr1p [Saccharomyces cerevisiae] [NCBI NR] Alcohol-sensitive RING finger protein 1 OS=Saccharomyces cerevisiae GN=ASR1 PE=2 SV=2 [Swiss-Prot] ASR1 Protein involved in a putative alcohol-responsive signaling pathway, accumulates in the nucleus under alcohol stress [mips] Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein [SGD] Chr XVI from 720420-719554, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] YPR093C SGDID:S0006297, Chr XVI from 720420-719554, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] YPR093C SGDID:S0006297, Chr XVI from 720422-719556, reverse complement, Uncharacterized ORF [10112005cervSGD.fasta] Asr1p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] ASR1 SGDID:S000006297, Chr XVI from 720422-719556, reverse complement, Verified ORF, "Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ASR1 SGDID:S000006297, Chr XVI from 720422-719556, reverse complement, Verified ORF, "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; co [yeast-200209-contam.fasta] Alcohol-sensitive RING finger protein 1 [nr-271106-contam.fasta] Protein involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain; Asr1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ASR1 SGDID:S000006297, Chr XVI from 720422-719556, reverse complement, Verified ORF, "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Alcohol-sensitive RING finger protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ASR1 PE=2 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ASR1 SGDID:S000006297, Chr XVI from 720424-719558, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" [yeast-030211-contam.fasta] Alcohol-sensitive RING finger protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ASR1 PE=4 SV=2 [YEAST.fasta.20131015] ASR1 SGDID:S000006297, Chr XVI from 720424-719558, Genome Release 64-2-1, reverse complement, Verified ORF, "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" [20141208_orf_trans.fasta] YPR093C SGDID:S000006297, Chr XVI from 720424-719558, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] Alcohol-sensitive RING finger protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ASR1 PE=3 SV=2 [uniprot_sprot.fasta.20160308]
Organism:	Saccharomyces cerevisiae
Length:	288 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	response to ethanol [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEECPICLAD DQEGEQFGCL NVCGHKFHLN CIREWHKYSI NLKCPICRVE STHLEVGEGQ  60
   61 HALSINLKMG FMIKNAIDYV GAETTNERNE DDTGEQDQEI EFLSERLRGT LVMDTIKIIQ 120
  121 CSICGDTDVS RLSLYCQDCE AIYHETCLRG LACEVGDRNT WQECTDCRSN ALLELRMGAI 180
  181 SSQLASYDSR NSMIFAGELR DKHSVKTQQM YEQIRNAKHK IQMHVRRALD RYPLPLLRFK 240
  241 DAYKHVNKQV SRKLYRLSDN KYLPDQYDYD SLARTGVHTE LLIYCHDE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ASR1 RPB2 RPO21
View Details	Krogan NJ, et al. (2006)		ARC15 ASR1 CAJ1 CDC7 CRN1 INP52 IRC22 MSK1 PNO1 PST2 RAD34 SAC6 SAR1 SLM1 TCP1 TED1 YPP1
View Details	Ho Y, et al. (2002)		ASR1 FPR1 RPB11 RPB3 RPB9 RPO21 YDR131C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	MDM30	ASR1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..97]	MSA	202.392997	View MSA. No confident structure predictions are available.
2	View Details	[98..288]	MSA	9.274996	View MSA. No confident structure predictions are available.
3	View Details	[178..211]	MSA	3.490996	View MSA. No confident structure predictions are available.
4	View Details	[212..288]	MSA	1.275992	View MSA. No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
binding	2.15523269781888	bayes_pls_golite062009
protein binding	1.2335781397975	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2