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Protein Overview: SWH1

General Information:
Name(s) found: SWH1 / YAR042W [SGD]
Description(s) found:
Found 13 descriptions.
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  • Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1188 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    early endosome [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Golgi trans cisterna [IDALink to PubMed article]
    Biological Process: sterol transport [IGILink to PubMed article]
    endocytosis [IGILink to PubMed article]
    exocytosis [IGILink to PubMed article]
    Molecular Function: oxysterol binding [ISSLink to PubMed article]
    phosphatidylinositol binding [ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQPDLSSVA ISKPLLKLKL LDALRQGSFP NLQDLLKKQF QPLDDPNVQQ VLHLMLHYAV  60
   61 QVAPMAVIKE IVHHWVSTTN TTFLNIHLDL NERDSNGNTP LHIAAYQSRG DIVAFLLDQP 120
  121 TINDCVLNNS HLQAIEMCKN LNIAQMMQVK RSTYVAETAQ EFRTAFNNRD FGHLESILSS 180
  181 PRNAELLDIN GMDPETGDTV LHEFVKKRDV IMCRWLLEHG ADPFKRDRKG KLPIELVRKV 240
  241 NENDTATSTK IAIDIELKKL LERATREQSV IDVTNNNLHE APTYKGYLKK WTNFAQGYKL 300
  301 RWFILSSDGK LSYYIDQADT KNACRGSLNM SSCSLHLDSS EKLKFEIIGG NNGVIRWHLK 360
  361 GNHPIETNRW VWAIQGAIRY AKDREILLHN GPYSPSLALS HGLSSKVSNK ENLHATSKRL 420
  421 TKSPHLSKST LTQNDHDNDD DSTNNNNNKS NNDYDDNNNN NNNDDDDYDD DDESRPLIEP 480
  481 LPLISSRSQS LSEITPGPHS RKSTVSSTRA ADIPSDDEGY SEDDSDDDGN SSYTMENGGE 540
  541 NDGDEDLNAI YGPYIQKLHM LQRSISIELA SLNELLQDKQ QHDEYWNTVN TSIETVSEFF 600
  601 DKLNRLTSQR EKRMIAQMTK QRDVNNVWIQ SVKDLEMELV DKDEKLVALD KERKNLKKML 660
  661 QKKLNNQPQV ETEANEESDD ANSMIKGSQE STNTLEEIVK FIEATKESDE DSDADEFFDA 720
  721 EEAASDKKAN DSEDLTTNKE TPANAKPQEE APEDESLIVI SSPQVEKKNQ LLKEGSFVGY 780
  781 EDPVRTKLAL DEDNRPKIGL WSVLKSMVGQ DLTKLTLPVS FNEPTSLLQR VSEDIEYSHI 840
  841 LDQAATFEDS SLRMLYVAAF TASMYASTTN RVSKPFNPLL GETFEYARTD GQYRFFTEQV 900
  901 SHHPPISATW TESPKWDFYG ECNVDSSFNG RTFAVQHLGL WYITIRPDHN ISVPEETYSW 960
  961 KKPNNTVIGI LMGKPQVDNS GDVKVTNHTT GDYCMLHYKA HGWTSAGAYE VRGEVFNKDD1020
 1021 KKLWVLGGHW NDSIYGKKVT ARGGELTLDR IKTANSATGG PKLDGSKFLI WKANERPSVP1080
 1081 FNLTSFALTL NALPPHLIPY LAPTDSRLRP DQRAMENGEY DKAAAEKHRV EVKQRAAKKE1140
 1141 REQKGEEYRP KWFVQEEHPV TKSLYWKFNG EYWNKRKNHD FKDCADIF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..392] PSI-BLAST 60.0 Ankyrin-R
    2 View Details [393..518] deduced N/A No confident structure predictions are available.
    3 View Details [519..580] deduced N/A No confident structure predictions are available.
    4 View Details [581..724] deduced N/A No confident structure predictions are available.
    5 View Details [725..855] MSA 1.180993 View MSA. No confident structure predictions are available.
    6 View Details [856..961] MSA 1.143975 View MSA. No confident structure predictions are available.
    7 View Details [962..1086] deduced N/A No confident structure predictions are available.
    8 View Details [1087..1188] MSA 3.462992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.46128459961519 bayes_pls_golite062009
  • protein binding
    		•  1.6716587413544 bayes_pls_golite062009
  • transporter activity
    		•  1.62618963155033 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.36262284136123 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.970617674606391 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.786064957992193 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.370811261525551 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.271428013908666 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.106792084948545 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0888208413153098 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • oxysterol binding
    		•  5.62675037461468 bayes_pls_golite062009
  • sterol binding
    		•  4.18891468109664 bayes_pls_golite062009
    		• 3.02967613614595 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • binding
    		•  2.38976505793668 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.88386267925687 bayes_pls_golite062009
  • lipid binding
    		•  1.8520231230392 bayes_pls_golite062009
  • phospholipid binding
    		•  1.53854106315366 bayes_pls_golite062009
  • cholesterol binding
    		•  0.644339278395346 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle