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Protein Overview: PZF1

General Information:
Name(s) found: PZF1 / YPR186C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 429 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [IPILink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase III promoter [IPILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: RNA polymerase III transcription factor activity [IPILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGEVLNNEG MPLAELKQET IPISRSESSE SLNSLTSTRS SSSNRPKTYF CDYDGCDKAF  60
   61 TRPSILTEHQ LSVHQGLRAF QCDKCAKSFV KKSHLERHLY THSDTKPFQC SYCGKGVTTR 120
  121 QQLKRHEVTH TKSFICPEEG CNLRFYKHPQ LRAHILSVHL HKLTCPHCNK SFQRPYRLRN 180
  181 HISKHHDPEV ENPYQCTFAG CCKEFRIWSQ LQSHIKNDHP KLKCPICSKP CVGENGLQMH 240
  241 MIIHDDSLVT KNWKCHICPD MSFSRKHDLL THYGSIHTEE DIPLELKYKI SDIQQLVQDH 300
  301 GVQLGNSKHS NEQDEEKISN RLRKRRKLTE NNNVEFLQNE VDLEKRLESG ENGLNLLLNT 360
  361 VGRKYRCFYN NCSRTFKTKE KYEKHIDKHK VHELKLKILQ EKEENKTLVD QNHKEPFIIQ 420
  421 KETQSAGDK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CAF4 ECM27 ERG6 MTF1 PZF1
    View Details Qiu et al. (2008) BDP1 PZF1 SPT15 TFB5 TFC1 TFC4 TFC6 TFC7 TFC8

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PZF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..188] PSI-BLAST 156.68867 Ying-yang 1 (yy1, zinc finger domain)
    2 View Details [189..350] MSA 8.637985 View MSA. No confident structure predictions are available.
    3 View Details [351..429] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.47951889934838 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35187767955595 bayes_pls_golite062009
  • DNA binding
    		•  4.31051339571017 bayes_pls_golite062009
  • transcription factor activity
    		•  3.28758716579796 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.07956158665183 bayes_pls_golite062009
  • binding
    		•  2.99742524370422 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.96255357208943 bayes_pls_golite062009
  • transcription activator activity
    		•  1.97757778483124 bayes_pls_golite062009
  • chromatin binding
    		•  1.91511881662436 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.35857850481346 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.26862497534835 bayes_pls_golite062009
  • transcription factor binding
    		•  1.23738346570539 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.16887811832337 bayes_pls_golite062009
  • protein binding
    		•  0.952480850696098 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.781519259241993 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.627794176881836 bayes_pls_golite062009
  • catalytic activity
    		•  0.263007611601737 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.0855506955761403 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle