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View Structure Prediction Details

Protein: PZF1
Organism: Saccharomyces cerevisiae
Length: 429 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PZF1.

Description E-value Query
Range
Subject
Range
gi|18916833 - gi|18916833|dbj|BAB85555.1| KIAA1969 protein [Homo sapiens]
0.0 [4..384] [202..576]

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Predicted Domain #1
Region A:
Residues: [1-188]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGEVLNNEG MPLAELKQET IPISRSESSE SLNSLTSTRS SSSNRPKTYF CDYDGCDKAF  60
   61 TRPSILTEHQ LSVHQGLRAF QCDKCAKSFV KKSHLERHLY THSDTKPFQC SYCGKGVTTR 120
  121 QQLKRHEVTH TKSFICPEEG CNLRFYKHPQ LRAHILSVHL HKLTCPHCNK SFQRPYRLRN 180
  181 HISKHHDP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 156.68867
Match: 1ubdC_
Description: Ying-yang 1 (yy1, zinc finger domain)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [189-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EVENPYQCTF AGCCKEFRIW SQLQSHIKND HPKLKCPICS KPCVGENGLQ MHMIIHDDSL  60
   61 VTKNWKCHIC PDMSFSRKHD LLTHYGSIHT EEDIPLELKY KISDIQQLVQ DHGVQLGNSK 120
  121 HSNEQDEEKI SNRLRKRRKL TENNNVEFLQ NEVDLEKRLE SG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [351-429]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ENGLNLLLNT VGRKYRCFYN NCSRTFKTKE KYEKHIDKHK VHELKLKILQ EKEENKTLVD  60
   61 QNHKEPFIIQ KETQSAGDK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.47951889934838 bayes_pls_golite062009
nucleic acid binding 4.35187767955595 bayes_pls_golite062009
DNA binding 4.31051339571017 bayes_pls_golite062009
transcription factor activity 3.28758716579796 bayes_pls_golite062009
transcription repressor activity 3.07956158665183 bayes_pls_golite062009
binding 2.99742524370422 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.96255357208943 bayes_pls_golite062009
transcription activator activity 1.97757778483124 bayes_pls_golite062009
chromatin binding 1.91511881662436 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.35857850481346 bayes_pls_golite062009
sequence-specific DNA binding 1.26862497534835 bayes_pls_golite062009
transcription factor binding 1.23738346570539 bayes_pls_golite062009
transcription corepressor activity 1.16887811832337 bayes_pls_golite062009
protein binding 0.952480850696098 bayes_pls_golite062009
transcription coactivator activity 0.781519259241993 bayes_pls_golite062009
transcription cofactor activity 0.627794176881836 bayes_pls_golite062009
catalytic activity 0.263007611601737 bayes_pls_golite062009
structure-specific DNA binding 0.0855506955761403 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle