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Protein Overview: SUA7

General Information:
Name(s) found: SUA7 / YPR086W [SGD]
Description(s) found:
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  • gi|6325343|ref|NP_015411.1| Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; Sua7p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S26707 transcription initiation factor IIB - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|172777|gb|AAA35126.1| Sua7 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|135633|sp|P29055.1|TF2B_YEAST RecName: Full=Transcription initiation factor IIB; AltName: Full=General transcription factor TFIIB; AltName: Full=Transcription factor E [NCBI NR]
  • gi|1230692|gb|AAB68135.1| Sua7p: Transcription initiation factor IIB (Swiss Prot. accession number P29055) [Saccharomyces cerevisiae] [NCBI NR]
  • Transcription initiation factor IIB OS=Saccharomyces cerevisiae GN=SUA7 PE=1 SV=1 [Swiss-Prot]
  • SUA7 TFIIB subunit (transcription initiation factor), factor E [mips]
  • Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II [SGD]
  • (P29055) Transcription initiation factor IIB (General transcription factor TFIIB) (Transcription factor E) [4932.FASTACCERV.txt]
  • Chr XVI from 710097-711134 [hmr_yeast5_DM3-1_pombe.fasta]
  • SUA7, Chr XVI from 710097-711134 [yeast_orfs2]
  • SUA7 SGDID:S0006290, Chr XVI from 710097-711134, Verified ORF [yeastflysequest.fasta]
  • SUA7 SGDID:S0006290, Chr XVI from 710099-711136, Verified ORF [10112005cervSGD.fasta]
  • Sua7p: Transcription initiation factor IIB (Swiss Prot. accession number P29055) [Saccharomyces cerevisiae]gi|6325343|ref|NP_015411.1| Sua7p [Saccharomyces cerevisiae]gi|135633|sp|P29055|TF2B_YEAST Transcription initiation factor IIB (General transcript [nrdb_11152004_Chlamydomonas]
  • SUA7 SGDID:S000006290, Chr XVI from 710099-711136, Verified ORF, "Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II; Sua7p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Sua7p: Transcription initiation factor IIB (Swiss Prot. accession number P29055) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Sua7 [nr-271106-contam.fasta]
  • Transcription initiation factor IIB (General transcription factor TFIIB) (Transcription factor E) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Transcription initiation factor IIB OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUA7 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SUA7 SGDID:S000006290, Chr XVI from 710101-711138, Genome Release 64-1-1, Verified ORF, "Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" [yeast-030211-contam.fasta]
  • SUA7 SGDID:S000006290, Chr XVI from 710101-711138, Genome Release 64-2-1, Verified ORF, "Transcription factor TFIIB; a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" [20141208_orf_trans.fasta]
  • YPR086W SGDID:S000006290, Chr XVI from 710101-711138, Genome Release 64-1-1, Verified ORF, "Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 345 amino acids

    Gene Ontology:
    Cellular Component: nucleoplasm [IPILink to PubMed articleLink to PubMed article]
    Biological Process: transcription initiation from RNA polymerase II promoter [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: general RNA polymerase II transcription factor activity [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed articleLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMTRESIDKR AGRRGPNLNI VLTCPECKVY PPKIVERFSE GDVVCALCGL VLSDKLVDTR  60
   61 SEWRTFSNDD HNGDDPSRVG EASNPLLDGN NLSTRIGKGE TTDMRFTKEL NKAQGKNVMD 120
  121 KKDNEVQAAF AKITMLCDAA ELPKIVKDCA KEAYKLCHDE KTLKGKSMES IMAASILIGC 180
  181 RRAEVARTFK EIQSLIHVKT KEFGKTLNIM KNILRGKSED GFLKIDTDNM SGAQNLTYIP 240
  241 RFCSHLGLPM QVTTSAEYTA KKCKEIKEIA GKSPITIAVV SIYLNILLFQ IPITAAKVGQ 300
  301 TLQVTEGTIK SGYKILYEHR DKLVDPQLIA NGVVSLDNLP GVEKK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) ASC1 ATG9 CLU1 FUN12 GLT1 HCR1 IST2 KTR5 LSG1 NIP1 NOG1 NOP7 PRT1 RIC1 RLI1 RPG1 SPT5 SUA7 SUI1 SUI2 SUI3 SUP45 TIF34 TIF35 TIF5 UTP6 YGL036W
    View Details Qiu et al. (2008) SUA7 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SUA7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] PSI-BLAST 87.751666 Transcription inititiation factor TFIIB, N-terminal domain
    2 View Details [73..232] PSI-BLAST 279.522879 Transcription factor IIB (TFIIB), core domain
    3 View Details [233..345] PSI-BLAST 279.522879 Transcription factor IIB (TFIIB), core domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  5.7605093262441 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  5.3609198248279 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  4.4866621324249 bayes_pls_golite062009
  • RNA polymerase activity
    		•  4.4866621324249 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.36253105801209 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.22594915484417 bayes_pls_golite062009
  • binding
    		•  2.05994835507055 bayes_pls_golite062009
  • DNA binding
    		•  2.01127684131811 bayes_pls_golite062009
  • positive transcription elongation factor activity
    		•  1.80334408907405 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.57988053581899 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.44591837933239 bayes_pls_golite062009
  • DNA primase activity
    		•  1.01743034310838 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.71113040164375 bayes_pls_golite062009
  • protein binding
    		•  0.557273506579609 bayes_pls_golite062009
  • catalytic activity
    		•  0.434839928397784 bayes_pls_golite062009
  • RNA polymerase II transcription elongation factor activity
    		•  0.33828634213987 bayes_pls_golite062009
    2
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  6.34389570239956 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  3.19553060844126 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  2.87088741581791 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.795846725429 bayes_pls_golite062009
  • binding
    		•  2.4204867358489 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.04886889839181 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.00665312545368 bayes_pls_golite062009
  • DNA binding
    		•  1.94297811210385 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  1.69439693414478 bayes_pls_golite062009
  • kinase regulator activity
    		•  1.65109787211976 bayes_pls_golite062009
  • protein binding
    		•  1.47106731485576 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21921365719206 bayes_pls_golite062009
  • transcription factor binding
    		•  0.749278791251235 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.729629809946521 bayes_pls_golite062009
  • positive transcription elongation factor activity
    		•  0.42590121577004 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.138191616709499 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0696060248241566 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle