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Protein Overview: YPR045C

General Information:
Name(s) found: YPR045C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein of unknown function; involvement in splicing based on pre-mRNA accumulation defect for many intron-containing genes; contains a SAC3 domain; physically interacts with Csn12p; YRP045C is not an essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 470 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNPYGHFTN NTTEDREASS QGGPFGQSLN RPLDYAGSFP SLTYNNNNFI ANQQPSLPLP  60
   61 EPRLSWNNVN QVSNPLMVTP LPGLQKRMNK NIKKKLPRVS KKASALSNGV SGNVMSNSNI 120
  121 VGHGAVGSAS GWKVEMGGSD ELERRKRRAE RFSQGPSATT NSNDNLNEDF ANLNAISSKS 180
  181 HQYDKKIHVV GRCQTLEKSY LRLTSEPNPD LIRPPNILQK MYCLLMDKYQ SKTATYTYLC 240
  241 DQFKSMRQDL RVQMIENSFT IKVYQTHARI ALENGDLGEF NQCQNRIMAL FENPTIPKKS 300
  301 YSEFICYSVL YSMLTEDYPS ISHLKLKLID DGSSEILEDE HVKMIFELSD MKLVGNYHYF 360
  361 MKNYLKLHKF EKCLINSFLN LEKLIFLTII CKSYNQVNLD FVKSEFNFNS IEETTNFLNE 420
  421 QNLTEFILNK QITDSNGKSS NIKILNTKGC RVQLIQNYMK SKKIDIKGQK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YPR045C Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] deduced N/A No confident structure predictions are available.
    2 View Details [193..470] Pfam 108.69897 SAC3/GANP/Nin1/mts3/eIF-3 p25 family No confident structure predictions are available.
    3 View Details [237..470] FFAS03 1.46 Crystal Structure of Human eIF3k

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.36800795249393 bayes_pls_golite062009
  • RNA binding
    		•  1.78069099517213 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.67826024217505 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.59410102249793 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.20954331617098 bayes_pls_golite062009
  • mRNA binding
    		•  1.10283692106023 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08645493064764 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.01831614309793 bayes_pls_golite062009
  • DNA binding
    		•  0.956143892328242 bayes_pls_golite062009
  • protein binding
    		•  0.914877292844892 bayes_pls_golite062009
  • transcription factor activity
    		•  0.371244009721798 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle