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Protein Overview: MCA1

General Information:
Name(s) found: MCA1 / YOR197W [SGD]
Description(s) found:
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  • gi|74627244|sp|Q08601|MCA1_YEAST Metacaspase-1 precursor [NCBI NR]
  • gi|6324771|ref|NP_014840.1| Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment; Mca1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013115|gb|AAT92851.1| YOR197W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S67089 hypothetical protein YOR197w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420469|emb|CAA99410.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Metacaspase-1 precursor - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot]
  • MCA1 Protein functions as a bona fide caspase in yeast [mips]
  • Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon hydrogen peroxide treatment; proposed to be involved in cell cycle progression [SGD]
  • >Q08601 (Q08601) Chromosome XV reading frame ORF YOR197W [4932.FASTACCERV.txt]
  • Chr XV from 717023-718384 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 717022-718383 [yeastorf3.fasta]
  • YOR197W, Chr XV from 717022-718383 [yeast_orfs2]
  • MCA1 SGDID:S0005723, Chr XV from 717023-718384, Verified ORF [yeastflysequest.fasta]
  • Mca1p [Saccharomyces cerevisiae]gi|51013115|gb|AAT92851.1| YOR197W [Saccharomyces cerevisiae]gi|1420469|emb|CAA99410.1| unnamed protein product [Saccharomyces cerevisiae]gi|2132083|pir||S67089 hypothetical protein YOR197w - yeast (Saccharomyces cerevis [nrdb_11152004_Chlamydomonas]
  • (Q08601) S.cerevisiae chromosome XV reading frame ORF YOR197w [cerv4932.FASTAC]
  • MCA1 SGDID:S000005723, Chr XV from 717023-718384, Verified ORF, "Putative cysteine protease similar to mammalian caspases, involved in regulation of apoptosis upon hydrogen peroxide treatment" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YOR197W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 453 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: apoptosis [IDALink to PubMed article]
    Molecular Function: caspase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMSLEVYLN YHQRRPTRFT IMYPGSGRYT YNNAGGNNGY QRPMAPPPNQ QYGQQYGQQY  60
   61 EQQYGQQYGQ QNDQQFSQQY APPPGPPPMA YNRPVYPPPQ FQQEQAKAQL SNGYNNPNVN 120
  121 ASNMYGPPQN MSLPPPQTQT IQGTDQPYQY SQCTGRRKAL IIGINYIGSK NQLRGCINDA 180
  181 HNIFNFLTNG YGYSSDDIVI LTDDQNDLVR VPTRANMIRA MQWLVKDAQP NDSLFLHYSG 240
  241 HGGQTEDLDG DEEDGMDDVI YPVDFETQGP IIDDEMHDIM VKPLQQGVRL TALFDSCHSG 300
  301 TVLDLPYTYS TKGIIKEPNI WKDVGQDGLQ AAISYATGNR AALIGSLGSI FKTVKGGMGN 360
  361 NVDRERVRQI KFSAADVVML SGSKDNQTSA DAVEDGQNTG AMSHAFIKVM TLQPQQSYLS 420
  421 LLQNMRKELA GKYSQKPQLS SSHPIDVNLQ FIM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SDP1 MCA1 2 Unpublished Fields Lab Data
    View Screen PRP40 MCA1 2 Unpublished Fields Lab Data
    View Screen ROM2 MCA1 2 Unpublished Fields Lab Data
    View Screen PET111 MCA1 2 Unpublished Fields Lab Data
    View Screen IMP4 MCA1 2 Unpublished Fields Lab Data
    View Screen MCA1 ESL2 2 Unpublished Fields Lab Data
    View Screen MCA1 VIP1 2 Unpublished Fields Lab Data
    View Screen MCA1 YRF1-6 2 Unpublished Fields Lab Data
    View Screen MCA1 MCA1 2 Unpublished Fields Lab Data
    View Screen SRO77 MCA1 2 Drees BL, et al. (2001)
    View Screen MCA1 GIP3 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] ORFEUS 13.18 Sec24
    2 View Details [101..453] ORFEUS 10.74 Apopain (caspase-3, cpp32)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.1899507591953 bayes_pls_golite062009
  • binding
    		•  2.82208570157139 bayes_pls_golite062009
  • hydrolase activity
    		•  2.12972595354571 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  2.11446327232186 bayes_pls_golite062009
  • endopeptidase activity
    		•  1.925193622235 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  1.92343694153446 bayes_pls_golite062009
  • protein binding
    		•  1.7732359472428 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.35765607557567 bayes_pls_golite062009
  • catalytic activity
    		•  0.976874866811795 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle