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View Structure Prediction Details

Protein: MCA1
Organism: Saccharomyces cerevisiae
Length: 453 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MCA1.

Description E-value Query
Range
Subject
Range
MCA1 - Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon h...
gi|151945290 - gi|151945290|gb|EDN63533.1| metacaspase [Saccharomyces cerevisiae YJM789]
gi|207341045 - gi|207341045|gb|EDZ69211.1| YOR197Wp-like protein [Saccharomyces cerevisiae AWRI1631]
0.0 [1..453] [1..453]
MCA1_SCHPO - Metacaspase-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pca1 PE=2 SV=1
pca1 (reserved) - caspase
0.0 [21..453] [11..425]
gi|3258570 - gi|3258570|gb|AAC24380.1| Unknown protein [Arabidopsis thaliana]
9.0E-90 [80..453] [2..390]
gi|37536924, gi|... - gi|37536924|ref|NP_922764.1| hypothetical protein [Oryza sativa (japonica cultivar-group)], gi|31433...
3.0E-89 [93..453] [12..378]
gi|19032270 - gi|19032270|emb|CAD24805.1| metacaspase [Trypanosoma brucei]
4.0E-85 [111..453] [34..342]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKMSLEVYLN YHQRRPTRFT IMYPGSGRYT YNNAGGNNGY QRPMAPPPNQ QYGQQYGQQY  60
   61 EQQYGQQYGQ QNDQQFSQQY APPPGPPPMA YNRPVYPPPQ 

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 13.18
Match: 1m2vB
Description: Sec24
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [101-453]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FQQEQAKAQL SNGYNNPNVN ASNMYGPPQN MSLPPPQTQT IQGTDQPYQY SQCTGRRKAL  60
   61 IIGINYIGSK NQLRGCINDA HNIFNFLTNG YGYSSDDIVI LTDDQNDLVR VPTRANMIRA 120
  121 MQWLVKDAQP NDSLFLHYSG HGGQTEDLDG DEEDGMDDVI YPVDFETQGP IIDDEMHDIM 180
  181 VKPLQQGVRL TALFDSCHSG TVLDLPYTYS TKGIIKEPNI WKDVGQDGLQ AAISYATGNR 240
  241 AALIGSLGSI FKTVKGGMGN NVDRERVRQI KFSAADVVML SGSKDNQTSA DAVEDGQNTG 300
  301 AMSHAFIKVM TLQPQQSYLS LLQNMRKELA GKYSQKPQLS SSHPIDVNLQ FIM

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.74
Match: 1cp3A
Description: Apopain (caspase-3, cpp32)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.1899507591953 bayes_pls_golite062009
binding 2.82208570157139 bayes_pls_golite062009
hydrolase activity 2.12972595354571 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.11446327232186 bayes_pls_golite062009
endopeptidase activity 1.925193622235 bayes_pls_golite062009
cysteine-type peptidase activity 1.92343694153446 bayes_pls_golite062009
protein binding 1.7732359472428 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.35765607557567 bayes_pls_golite062009
catalytic activity 0.976874866811795 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle