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Protein Overview: RUP1

General Information:
Name(s) found: RUP1 / YOR138C [SGD]
Description(s) found:
Found 30 descriptions.
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  • Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 671 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: protein deubiquitination [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDNQAVKSL LEMGIPHEVA VDALQRTGGN LEAAVNFIFS NELPEQAEMG EENDGSQPRI  60
   61 SENKIVAGTK PCDVPNNGDQ DIDMPDVSGV DVDYDDDEDI TDERSGSNST SGCRVTAQNY 120
  121 DRYSISETSI PPPSYSIVQH NEFKSNVGDP TVVLPLPLNS LIESYFGLFA LLTAVYFPHV 180
  181 FLKPDFKDLN YRADWFKGSS FTEPKYRLAY CEAEDGSTTS EIVLASGPNE GLQPHLLWQL 240
  241 QKLISVVNTR KCERAFVSAK VFTSSLEPQL RSKLADSEHL YEVLPAFIKS LAVDLEMCPG 300
  301 IRDRETRSLF ISSALHTPNK NEPPMETFLS LFHFLPEEYD SNLYKMFNVL LYPEEEEEEE 360
  361 DVIRGGEQEE ARYVEPENTL KEVAPVLTIL FNELETNTES VSLPNGVDIP LEFYPQLYTK 420
  421 QCKDQLIRHI ISKRKQARTR SRCLLQEINE LKSYQGKNIS TILESTLAYL QTIPDDANNE 480
  481 AAKQIASLKD TLNSARAAKM EEYKDLASKL HGEWNLSHPE THIINTAKQL GLIENPYILT 540
  541 MAALSPYSYF IRSRNGAWSW IQSNTLGTEF KVKKCSSPSV VQEAIKHGTK YASETPLMFI 600
  601 YCEEGKIPTE EVVAEALKSN SGCLKFAEDD QNSLKTLRSQ FFDGMGDPEQ ATNNINNGND 660
  661 NDNDDDIDSD N

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RSP5 RUP1 UBP2
    View Details Krogan NJ, et al. (2006) ADE6 BUL1 LDB19 RSP5 RUP1 UBP2 YHR131C
    View Details Gavin AC, et al. (2006) RUP1 UBP2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RUP1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..67] Pfam 7.619789 UBA/TS-N domain No confident structure predictions are available.
    2 View Details [68..671] deduced N/A No confident structure predictions are available.
    3 View Details [149..671] FFAS03 3.1 Ubiquitin carboxyl-terminal hydrolase 7 (USP7, HAUSP)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cysteine-type peptidase activity
    		•  6.0242292884398 bayes_pls_golite062009
  • small conjugating protein-specific protease activity
    		•  5.90858078304578 bayes_pls_golite062009
  • ubiquitin-specific protease activity
    		•  5.44933450089323 bayes_pls_golite062009
  • ubiquitin thiolesterase activity
    		•  3.74006277974234 bayes_pls_golite062009
  • SUMO-specific protease activity
    		•  2.21040757005122 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  2.11491900255607 bayes_pls_golite062009
  • binding
    		•  1.33631135736211 bayes_pls_golite062009
  • catalytic activity
    		•  0.995453662223124 bayes_pls_golite062009
  • protein binding
    		•  0.971758173254614 bayes_pls_golite062009
  • peptidase activity
    		•  0.906081979704688 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.771565725012421 bayes_pls_golite062009
  • hydrolase activity
    		•  0.60043152196744 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.457218859985687 bayes_pls_golite062009
  • NEDD8-specific protease activity
    		•  0.286821085697906 bayes_pls_golite062009
  • DNA binding
    		•  0.178287899185051 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.153973186741348 bayes_pls_golite062009
  • endopeptidase activity
    		•  0.134447097497472 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  0.0340549989533036 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle