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Protein Overview: GLO4

General Information:
Name(s) found: GLO4 / YOR040W [SGD]
Description(s) found:
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  • gi|6324614|ref|NP_014683.1| Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; Glo4p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013381|gb|AAT92984.1| YOR040W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2494852|sp|Q12320.1|GLO4_YEAST RecName: Full=Hydroxyacylglutathione hydrolase, mitochondrial; AltName: Full=Glyoxalase II; Short=Glx II; Flags: Precursor [NCBI NR]
  • pir||S62179 hypothetical protein YOR040w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1771606|emb|CAA58065.1| glyoxalase-II [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1420164|emb|CAA99230.1| GLO4 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1041665|emb|CAA60759.1| ORF OR26.33 [Saccharomyces cerevisiae] [NCBI NR]
  • Hydroxyacylglutathione hydrolase, mitochondrial OS=Saccharomyces cerevisiae GN=GLO4 PE=2 SV=1 [Swiss-Prot]
  • GLO4 Glyoxalase II (hydroxyacylglutathione hydrolase) [mips]
  • Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [SGD]
  • (Q12320) Hydroxyacylglutathione hydrolase, mitochondrial precursor (EC 3.1.2.6) (Glyoxalase II) (Glx II) [4932.FASTACCERV.txt]
  • Chr XV from 407063-407920 [hmr_yeast5_DM3-1_pombe.fasta]
  • GLO4, Chr XV from 407063-407920 [yeast_orfs2]
  • GLO4 SGDID:S0005566, Chr XV from 407063-407920, Verified ORF [yeastflysequest.fasta]
  • Glo4p [Saccharomyces cerevisiae]gi|51013381|gb|AAT92984.1| YOR040W [Saccharomyces cerevisiae]gi|1041665|emb|CAA60759.1| ORF OR26.33 [Saccharomyces cerevisiae]gi|1771606|emb|CAA58065.1| glyoxalase-II [Saccharomyces cerevisiae]gi|1420164|emb|CAA99230.1| [nrdb_11152004_Chlamydomonas]
  • GLO4 SGDID:S000005566, Chr XV from 407063-407920, Verified ORF, "Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • GLO4 SGDID:S000005566, Chr XV from 407064-407921, Verified ORF, "Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [yeast-contam.fasta]
  • YOR040W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • GLO4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Hydroxyacylglutathione hydrolase, mitochondrial precursor (Glyoxalase II) (Glx II) [nr-271106-contam.fasta]
  • Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; Glo4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • glyoxalase-II [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ORF OR26.33 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Hydroxyacylglutathione hydrolase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO4 PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GLO4 SGDID:S000005566, Chr XV from 407064-407921, Genome Release 64-1-1, Verified ORF, "Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [yeast-030211-contam.fasta]
  • Hydroxyacylglutathione hydrolase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO4 PE=3 SV=1 [YEAST.fasta.20131015]
  • GLO4 SGDID:S000005566, Chr XV from 407064-407921, Genome Release 64-2-1, Verified ORF, "Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YOR040W SGDID:S000005566, Chr XV from 407064-407921, Genome Release 64-1-1, Verified ORF, "Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 285 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: carbohydrate metabolic process [IMPLink to PubMed article]
    methylglyoxal catabolic process to D-lactate [IDALink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    Molecular Function: hydroxyacylglutathione hydrolase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLLQQIRN MHVKPIKMRW LTGGVNYSYL LSTEDRRNSW LIDPAEPLEV SPKLSAEEKK  60
   61 SIDAIVNTHH HYDHSGGNLA LYSILCQENS GHDIKIIGGS KSSPGVTEVP DNLQQYHLGN 120
  121 LRVTCIRTPC HTKDSICYYI KDLETGEQCI FTGDTLFIAG CGRFFEGTGR DMDMALNQIM 180
  181 LRAVGETNWN KVKIYPGHEY TKGNVSFIRA KIYSDIGQNK EFDALEQYCK SNECTTGHFT 240
  241 LRDELGYNPF MRLDDRAVRL AVGDTAGTYP RSVVMQELRK LKNAM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARA2 AYT1 BRO1 CDC73 CTR9 GLO4 HHT1, HHT2 LEO1 PAF1 PML39 POB3 PSH1 RTF1 SEN1 SPT16 YHR035W

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GLO4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..130] PSI-BLAST 393.29073 Glyoxalase II (hydroxyacylglutathione hydrolase)
    2 View Details [131..200] PSI-BLAST 393.29073 Glyoxalase II (hydroxyacylglutathione hydrolase)
    3 View Details [201..285] PSI-BLAST 393.29073 Glyoxalase II (hydroxyacylglutathione hydrolase)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydroxyacylglutathione hydrolase activity
    		•  3.53012507604564 bayes_pls_golite062009
  • catalytic activity
    		•  0.941400907161877 bayes_pls_golite062009
  • binding
    		•  0.900972948435178 bayes_pls_golite062009
  • thiolester hydrolase activity
    		•  0.802604883362264 bayes_pls_golite062009
  • hydrolase activity
    		•  0.021392930321391 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle