YRC Public Data Repository - Protein Structure Prediction

Protein:	GLO4
Organism:	Saccharomyces cerevisiae
Length:	285 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLO4.

Description	E-value	Query Range	Subject Range
gi\|207341246 - gi\|207341246\|gb\|EDZ69353.1\| YOR040Wp-like protein [Saccharomyces cerevisiae AWRI1631] GLO4_YEAST - Hydroxyacylglutathione hydrolase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S2... GLO4 - Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and... gi\|151945670 - gi\|151945670\|gb\|EDN63911.1\| glyoxylase II [Saccharomyces cerevisiae YJM789] gi\|190407379 - gi\|190407379\|gb\|EDV10646.1\| glyoxylase-II [Saccharomyces cerevisiae RM11-1a]	6.0E-63	[1..285]	[1..285]
gi\|25406895, gi\|... - gi\|8810475\|gb\|AAF80136.1\|AC024174_18 Contains similarity to glyoxalase II isozyme from Arabidopsis t...	2.0E-61	[4..283]	[250..508]
gi\|16209608 - gi\|16209608\|gb\|AAL14249.1\| glyoxalase II [Oryza sativa] gi\|113631906, gi... - gi\|50726249\|dbj\|BAD33825.1\| glyoxalase II [Oryza sativa Japonica Group], gi\|215737215\|dbj\|BAG96144.1... gi\|218202459 - gi\|218202459\|gb\|EEC84886.1\| hypothetical protein OsI_32046 [Oryza sativa Indica Group]	4.0E-60	[5..283]	[77..334]
CG4365-PA - This gene is referred to in FlyBase by the symbol Dmel\CG4365 (CG4365, FBgn0037024). It is a protein... gi\|220954192, gi... - gi\|220954192\|gb\|ACL89639.1\| CG4365-PA [synthetic construct], gi\|220944250\|gb\|ACL84668.1\| CG4365-PA [...	3.0E-59	[7..283]	[43..301]

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Predicted Domain #1

Region A:
Residues: [1-130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLLQQIRN MHVKPIKMRW LTGGVNYSYL LSTEDRRNSW LIDPAEPLEV SPKLSAEEKK  60
   61 SIDAIVNTHH HYDHSGGNLA LYSILCQENS GHDIKIIGGS KSSPGVTEVP DNLQQYHLGN 120
  121 LRVTCIRTPC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	393.29073
Match:	1qh3A_
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydroxyacylglutathione hydrolase activity	3.53012507604564	bayes_pls_golite062009
catalytic activity	0.941400907161877	bayes_pls_golite062009
binding	0.900972948435178	bayes_pls_golite062009
thiolester hydrolase activity	0.802604883362264	bayes_pls_golite062009
hydrolase activity	0.021392930321391	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [131-200]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HTKDSICYYI KDLETGEQCI FTGDTLFIAG CGRFFEGTGR DMDMALNQIM LRAVGETNWN  60
   61 KVKIYPGHEY

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	393.29073
Match:	1qh3A_
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [201-285]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TKGNVSFIRA KIYSDIGQNK EFDALEQYCK SNECTTGHFT LRDELGYNPF MRLDDRAVRL  60
   61 AVGDTAGTYP RSVVMQELRK LKNAM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	393.29073
Match:	1qh3A_
Description:	Glyoxalase II (hydroxyacylglutathione hydrolase)
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: