Protein Overview: EXO1

General Information:
Name(s) found:	EXO1 / YOR033C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324607\|ref\|NP_014676.1\| 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; Exo1p [Saccharomyces cerevisia [NCBI NR] pir\|\|S62169 DHS1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1840127\|gb\|AAB47428.1\| Exo1p [Saccharomyces cerevisiae] [NCBI NR] gi\|1706421\|sp\|P39875.2\|EXO1_YEAST RecName: Full=Exodeoxyribonuclease 1; AltName: Full=Exodeoxyribonuclease I; Short=Exonuclease I; Short=EXO I; AltName: Full=Protein DHS1 [NCBI NR] gi\|1420150\|emb\|CAA99223.1\| DHS1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1041655\|emb\|CAA60749.1\| ORF OR26.23 [Saccharomyces cerevisiae] [NCBI NR] Exodeoxyribonuclease 1 OS=Saccharomyces cerevisiae GN=EXO1 PE=1 SV=2 [Swiss-Prot] EXO1 Exonuclease which interacts with Msh2p, is critical for generating ssDNA in subtelomeric X repeats and internal single-copy sequences [mips] 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains [SGD] (P39875) Exonuclease I (EXO I) (DHS1 protein) [4932.FASTACCERV.txt] Chr XV from 394523-392415, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XV from 392415-394523, reverse complement [yeastorf3.fasta] EXO1, Chr XV from 392415-394523, reverse complement [yeast_orfs2] EXO1 SGDID:S0005559, Chr XV from 394523-392415, reverse complement, Verified ORF [yeastflysequest.fasta] 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains [Saccharomyces cerevisiae]gi\|1041655\|emb\|CAA60749.1\| ORF O [nrdb_11152004_Chlamydomonas] (P39875) Exodeoxyribonuclease I (EC 3.1.11.-) (Exonuclease I) (EXO I) (DHS1 protein) [cerv4932.FASTAC] EXO1 SGDID:S000005559, Chr XV from 394523-392415, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] EXO1 SGDID:S000005559, Chr XV from 394524-392416, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved [yeast-contam.fasta] ORF OR26.23 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Exodeoxyribonuclease 1 (Exodeoxyribonuclease I) (Exonuclease I) (EXO I) (Protein DHS1) [nr-271106-contam.fasta] 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; Exo1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DHS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Exo1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] EXO1 SGDID:S000005559, Chr XV from 394524-392416, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Exodeoxyribonuclease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EXO1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] EXO1 SGDID:S000005559, Chr XV from 394524-392416, Genome Release 64-1-1, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains" [yeast-030211-contam.fasta] EXO1 SGDID:S000005559, Chr XV from 394524-392416, Genome Release 64-2-1, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair, MMS2 error-free branch of the post replication (PRR) pathway and DNA mismatch repair; role in telomere maintenance; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress; EXO1 has a paralog, DIN7, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YOR033C SGDID:S000005559, Chr XV from 394524-392416, Genome Release 64-1-1, reverse complement, Verified ORF, "5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	702 amino acids
Gene Ontology:
Cellular Component:	nucleus [IPI]
Biological Process:	DNA double-strand break processing [IGI][IMP] telomere maintenance [IGI] mismatch repair [IMP]
Molecular Function:	5'-3' exonuclease activity [IDA] 5'-flap endonuclease activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIQGLLPQL KPIQNPVSLR RYEGEVLAID GYAWLHRAAC SCAYELAMGK PTDKYLQFFI  60
   61 KRFSLLKTFK VEPYLVFDGD AIPVKKSTES KRRDKRKENK AIAERLWACG EKKNAMDYFQ 120
  121 KCVDITPEMA KCIICYCKLN GIRYIVAPFE ADSQMVYLEQ KNIVQGIISE DSDLLVFGCR 180
  181 RLITKLNDYG ECLEICRDNF IKLPKKFPLG SLTNEEIITM VCLSGCDYTN GIPKVGLITA 240
  241 MKLVRRFNTI ERIILSIQRE GKLMIPDTYI NEYEAAVLAF QFQRVFCPIR KKIVSLNEIP 300
  301 LYLKDTESKR KRLYACIGFV IHRETQKKQI VHFDDDIDHH LHLKIAQGDL NPYDFHQPLA 360
  361 NREHKLQLAS KSNIEFGKTN TTNSEAKVKP IESFFQKMTK LDHNPKVANN IHSLRQAEDK 420
  421 LTMAIKRRKL SNANVVQETL KDTRSKFFNK PSMTVVENFK EKGDSIQDFK EDTNSQSLEE 480
  481 PVSESQLSTQ IPSSFITTNL EDDDNLSEEV SEVVSDIEED RKNSEGKTIG NEIYNTDDDG 540
  541 DGDTSEDYSE TAESRVPTSS TTSFPGSSQR SISGCTKVLQ KFRYSSSFSG VNANRQPLFP 600
  601 RHVNQKSRGM VYVNQNRDDD CDDNDGKNQI TQRPSLRKSL IGARSQRIVI DMKSVDERKS 660
  661 FNSSPILHEE SKKRDIETTK SSQARPAVRS ISLLSQFVYK GK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	EXO1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..361]	PSI-BLAST	188.30103	Flap endonuclease-1 (Fen-1 nuclease)
2	View Details	[362..427]	PSI-BLAST	3.0	Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
3	View Details	[428..702]	deduced	N/A	No confident structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: EXO1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: