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View Structure Prediction Details

Protein: EXO1
Organism: Saccharomyces cerevisiae
Length: 702 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EXO1.

Description E-value Query
Range		 Subject
Range
EXO1_YEAST - Exodeoxyribonuclease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EXO1 PE=1 SV=2
EXO1 - 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DN...
 0.0 [1..702] [1..702]
gi|3513573 - gi|3513573|gb|AAC33874.1| exonuclease I [Homo sapiens]
 0.0 [1..552] [1..541]
EXO1_XENLA - Exonuclease 1 OS=Xenopus laevis GN=exo1 PE=2 SV=1
 0.0 [1..597] [1..604]
EXO1_MOUSE - Exonuclease 1 OS=Mus musculus GN=Exo1 PE=2 SV=2
 0.0 [1..544] [1..532]
gi|21360461, gi|... - gi|21360461|gb|AAM47346.1| At1g18090/T10F20_6 [Arabidopsis thaliana], gi|18394573|ref|NP_564047.1| e...
 0.0 [1..539] [1..523]

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Predicted Domain #1
Region A:
Residues: [1-361] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIQGLLPQL KPIQNPVSLR RYEGEVLAID GYAWLHRAAC SCAYELAMGK PTDKYLQFFI  60
   61 KRFSLLKTFK VEPYLVFDGD AIPVKKSTES KRRDKRKENK AIAERLWACG EKKNAMDYFQ 120
  121 KCVDITPEMA KCIICYCKLN GIRYIVAPFE ADSQMVYLEQ KNIVQGIISE DSDLLVFGCR 180
  181 RLITKLNDYG ECLEICRDNF IKLPKKFPLG SLTNEEIITM VCLSGCDYTN GIPKVGLITA 240
  241 MKLVRRFNTI ERIILSIQRE GKLMIPDTYI NEYEAAVLAF QFQRVFCPIR KKIVSLNEIP 300
  301 LYLKDTESKR KRLYACIGFV IHRETQKKQI VHFDDDIDHH LHLKIAQGDL NPYDFHQPLA 360
  361 N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 188.30103
Match: 1a76__
Description: Flap endonuclease-1 (Fen-1 nuclease)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on ester bonds 5.44893156272125 bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity 4.19173394038227 bayes_pls_golite062009
flap endonuclease activity 4.10438637013244 bayes_pls_golite062009
exonuclease activity 3.55065728618765 bayes_pls_golite062009
endonuclease activity 3.40075034200919 bayes_pls_golite062009
endodeoxyribonuclease activity 3.29138075959109 bayes_pls_golite062009
deoxyribonuclease activity 3.25110450559975 bayes_pls_golite062009
5'-3' exonuclease activity 3.19536858640519 bayes_pls_golite062009
nuclease activity 2.50181033811809 bayes_pls_golite062009
hydrolase activity 2.4418166499042 bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.3324415860722 bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity 2.26658239783943 bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity 2.09057967200253 bayes_pls_golite062009
nucleic acid binding 2.02510018436829 bayes_pls_golite062009
exodeoxyribonuclease activity 2.0005433655378 bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.9833086883205 bayes_pls_golite062009
DNA binding 1.93844174573408 bayes_pls_golite062009
binding 1.86985246794396 bayes_pls_golite062009
ribonuclease activity 1.84042322103694 bayes_pls_golite062009
5'-flap endonuclease activity 1.81850767854435 bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity 1.61167902830399 bayes_pls_golite062009
damaged DNA binding 1.42836853175021 bayes_pls_golite062009
catalytic activity 1.37534898662234 bayes_pls_golite062009
ribonuclease H activity 1.29762010718359 bayes_pls_golite062009
structure-specific DNA binding 1.16717206930423 bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity 1.15948049342759 bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity 1.10463550341524 bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters 0.901965019685213 bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 0.512509234493511 bayes_pls_golite062009
protein binding 0.389020243587168 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.319622686426271 bayes_pls_golite062009
endoribonuclease activity 0.312346277055223 bayes_pls_golite062009
DNA polymerase activity 0.250070491623222 bayes_pls_golite062009
DNA-directed DNA polymerase activity 0.233683378650593 bayes_pls_golite062009
double-stranded DNA binding 0.0978227645302046 bayes_pls_golite062009
3'-5'-exodeoxyribonuclease activity 0.0205129272358 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [362-427] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 REHKLQLASK SNIEFGKTNT TNSEAKVKPI ESFFQKMTKL DHNPKVANNI HSLRQAEDKL  60
   61 TMAIKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.0
Match: 1d9dA_
Description: Exonuclease domain of prokaryotic DNA polymerase; DNA polymerase I (Klenow fragment)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [428-702] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RKLSNANVVQ ETLKDTRSKF FNKPSMTVVE NFKEKGDSIQ DFKEDTNSQS LEEPVSESQL  60
   61 STQIPSSFIT TNLEDDDNLS EEVSEVVSDI EEDRKNSEGK TIGNEIYNTD DDGDGDTSED 120
  121 YSETAESRVP TSSTTSFPGS SQRSISGCTK VLQKFRYSSS FSGVNANRQP LFPRHVNQKS 180
  181 RGMVYVNQNR DDDCDDNDGK NQITQRPSLR KSLIGARSQR IVIDMKSVDE RKSFNSSPIL 240
  241 HEESKKRDIE TTKSSQARPA VRSISLLSQF VYKGK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle