Protein Overview: MRPL22

General Information:
Name(s) found:	MRPL22 / YNL177C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6324152\|ref\|NP_014222.1\| Mitochondrial ribosomal protein of the large subunit; Mrpl22p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S63132 hypothetical protein YNL177c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1730808\|sp\|P53881.1\|RM22_YEAST RecName: Full=54S ribosomal protein L22, mitochondrial; Flags: Precursor [NCBI NR] gi\|1302156\|emb\|CAA96069.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] 54S ribosomal protein L22, mitochondrial OS=Saccharomyces cerevisiae GN=MRPL22 PE=1 SV=1 [Swiss-Prot] MRPL22 Mitochondrial ribosomal protein, large subunit [mips] Mitochondrial ribosomal protein of the large subunit [SGD] YNL177C, Chr XIV from 303683-304612, reverse complement [yeast_orfs2] Chr XIV from 303683-304612, reverse complement [yeastorf3.fasta] Chr XIV from 304612-303683, reverse complement [yeastorf5.fasta] (P53881) Hypothetical 34.9 kDa protein in RPS3-PSD1 intergenic region [4932.FASTACCERV.txt] MRPL22 SGDID:S0005121, Chr XIV from 304615-303686, reverse complement, Verified ORF [yeastflysequest.fasta] Mitochondrial ribosomal protein of the large subunit [Saccharomyces cerevisiae]gi\|1302156\|emb\|CAA96069.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2131909\|pir\|\|S63132 hypothetical protein YNL177c - yeast (Saccharomyces cerevisiae)gi\|1730808 [nrdb_11152004_Chlamydomonas] (P53881) 60S ribosomal protein L22, mitochondrial precursor [cerv4932.FASTAC] MRPL22 SGDID:S000005121, Chr XIV from 304617-303688, reverse complement, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial ribosomal protein of the large subunit; Mrpl22p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] 60S ribosomal protein L22, mitochondrial precursor [nr-271106-contam.fasta] [chemostatdb.fasta]
Organism:	Saccharomyces cerevisiae
Length:	309 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial large ribosomal subunit [IPI][ISS]
Biological Process:	aerobic respiration [IEP][IMP] translation [IC]
Molecular Function:	structural constituent of ribosome [IPI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNFHTARISQ VGVISRALLS SVSRRWIHVT PISLNNSGGS LFGSITENKP KEGKNRGDED  60
   61 AGSFSNRLAI ASDSSGEAPE VNRDSITIEN DKLLQQHIIS LQQPEQLASQ SLLSPLKREI 120
  121 YEANCKINGG FYKKDTIVKL PNSSERYKLK FTKREIEVLE PSVYAQSYRI KSSMKKATLL 180
  181 LRLLGGLDVM KAISQCHFSN KKIAREVAEL LQKGVKDGQK LGLKPEDLYI SQIWTGSDGF 240
  241 WRKRVEFKAR TRIGIISHPY IHVRCILRTK SVTKRRLAYE AHLKEQKRAP WVQLGDKPIR 300
  301 GVTGGVYKW

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		IMG1 MHR1 MRP49 MRPL13 MRPL20 MRPL22 MRPL8 MRPL9
View Details	(MIPS) Mewes HW, et al. (2004)		IMG1 IMG2 MNP1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 RML2 RTC6 YDR115W YML6
View Details	Krogan NJ, et al. (2006)		MRPL22 TAN1
View Details	Gavin AC, et al. (2006)		DUR1,2 MRPL22 PRO1
View Details	Qiu et al. (2008)		IMG1 IMG2 MHR1 MNP1 MRP10 MRP13 MRP17 MRP2 MRP20 MRP21 MRP4 MRP49 MRP51 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 MRPS12 MRPS16 MRPS17 MRPS18 MRPS28 MRPS35 MRPS5 MRPS8 MRPS9 NAM9 PET123 RML2 RSM18 RSM19 RSM22 RSM23 RSM24 RSM25 RSM26 RSM27 RSM28 RSM7 RTC6 SWS2 VAR1 YDR115W YML6 YMR31 YNL122C

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	UBC7	MRPL22	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MRPL22	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..124]	deduced	N/A	No confident structure predictions are available.
2	View Details	[125..309]	PSI-BLAST	32.0	No description for 1lnrQ_ was found.

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
structural constituent of ribosome	9.71138472170121	bayes_pls_golite062009
structural molecule activity	9.13471776263155	bayes_pls_golite062009
binding	1.30630421512737	bayes_pls_golite062009
protein binding	0.592567938703741	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.83

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2