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Protein Overview: IDP3

General Information:
Name(s) found: IDP3 / YNL009W [SGD]
Description(s) found:
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  • gi|6324319|ref|NP_014389.1| Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; Idp3p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013759|gb|AAT93173.1| YNL009W [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S62921 isocitrate dehydrogenase (NADP) (EC 1.1.1.42) IDP3 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1708405|sp|P53982.1|IDHH_YEAST RecName: Full=Isocitrate dehydrogenase [NADP]; Short=IDH; AltName: Full=Oxalosuccinate decarboxylase; AltName: Full=NADP(+)-specific ICDH; AltName: Full=IDP [NCBI NR]
  • gi|1301828|emb|CAA95869.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • Isocitrate dehydrogenase [NADP] OS=Saccharomyces cerevisiae GN=IDP3 PE=1 SV=1 [Swiss-Prot]
  • IDP3 Isocitrate dehydrogenase, NADP-dependent [mips]
  • Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids [SGD]
  • IDP3, Chr XIV from 614817-616079 [yeast_orfs2]
  • Chr XIV from 614817-616079 [yeastorf3.fasta]
  • (P53982) Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) [4932.FASTACCERV.txt]
  • IDP3 SGDID:S0004954, Chr XIV from 614819-616081, Verified ORF [yeastflysequest.fasta]
  • IDP3 SGDID:S0004954, Chr XIV from 614820-616082, Verified ORF [10112005cervSGD.fasta]
  • Idp3p [Saccharomyces cerevisiae]gi|51013759|gb|AAT93173.1| YNL009W [Saccharomyces cerevisiae]gi|1301828|emb|CAA95869.1| unnamed protein product [Saccharomyces cerevisiae]gi|1708405|sp|P53982|IDHH_YEAST Isocitrate dehydrogenase [NADP] (Oxalosuccinate de [nrdb_11152004_Chlamydomonas]
  • IDP3 SGDID:S000004954, Chr XIV from 614822-616084, Verified ORF, "Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP) [nr-271106-contam.fasta]
  • Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; Idp3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YNL009W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • IDP3 SGDID:S000004954, Chr XIV from 614823-616085, Verified ORF, "Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids" [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • [chemostatdb.fasta]
  • Isocitrate dehydrogenase [NADP] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IDP3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • IDP3 SGDID:S000004954, Chr XIV from 614821-616083, Genome Release 64-1-1, Verified ORF, "Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids" [yeast-030211-contam.fasta]
  • IDP3 SGDID:S000004954, Chr XIV from 614821-616083, Genome Release 64-2-1, Verified ORF, "Peroxisomal NADP-dependent isocitrate dehydrogenase; catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids; IDP3 has a paralog, IDP2, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNL009W SGDID:S000004954, Chr XIV from 614821-616083, Genome Release 64-1-1, Verified ORF, "Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • Isocitrate dehydrogenase [NADP] OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=IDP3 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Saccharomyces cerevisiae
    Length: 420 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article][TASLink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: fatty acid beta-oxidation [IMPLink to PubMed article]
    isocitrate metabolic process [TASLink to PubMed article]
    NADPH regeneration [TASLink to PubMed article]
    Molecular Function: isocitrate dehydrogenase (NADP+) activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKIKVVHPI VEMDGDEQTR VIWKLIKEKL ILPYLDVDLK YYDLSIQERD RTNDQVTKDS  60
   61 SYATLKYGVA VKCATITPDE ARMKEFNLKE MWKSPNGTIR NILGGTVFRE PIIIPKIPRL 120
  121 VPHWEKPIII GRHAFGDQYR ATDIKIKKAG KLRLQFSSDD GKENIDLKVY EFPKSGGIAM 180
  181 AMFNTNDSIK GFAKASFELA LKRKLPLFFT TKNTILKNYD NQFKQIFDNL FDKEYKEKFQ 240
  241 ALKITYEHRL IDDMVAQMLK SKGGFIIAMK NYDGDVQSDI VAQGFGSLGL MTSILITPDG 300
  301 KTFESEAAHG TVTRHFRKHQ RGEETSTNSI ASIFAWTRAI IQRGKLDNTD DVIKFGNLLE 360
  361 KATLDTVQVG GKMTKDLALM LGKTNRSSYV TTEEFIDEVA KRLQNMMLSS NEDKKGMCKL 420
  421

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GDI1 IDP3 MRS6 VPS21 YPT6
    View Details Qiu et al. (2008) IDP3 MDH3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #33 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #16 Mitotic-New search criteria Keck JM, et al. (2011)
    View Run None Entered #18 Mitotic Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..420] PSI-BLAST 132.0103 3-isopropylmalate dehydrogenase, IPMDH

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • isocitrate dehydrogenase (NAD+) activity
    		•  5.9567768649084 bayes_pls_golite062009
  • isocitrate dehydrogenase activity
    		•  5.76817846591752 bayes_pls_golite062009
  • isocitrate dehydrogenase (NADP+) activity
    		•  3.47645456015586 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.74237430402883 bayes_pls_golite062009
  • catalytic activity
    		•  2.71251959637136 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  2.46799258909805 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  2.38235863668553 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  1.15484868227001 bayes_pls_golite062009
  • 3-isopropylmalate dehydrogenase activity
    		•  0.848289435089509 bayes_pls_golite062009
  • binding
    		•  0.530580225668688 bayes_pls_golite062009
  • protein binding
    		•  0.074256700284446 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle