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Protein Overview: RKR1

General Information:
Name(s) found: RKR1 / YMR247C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Nuclear RING domain protein with functional connections to chromatin modification; may interact with ribosomes, based on co-purification experiments; YMR247C is not an essential gene [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1562 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: chromatin modification [IGILink to PubMed article]
    chromatin silencing at telomere [IMPLink to PubMed article]
    protein ubiquitination [IDALink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFGGINTFQ QYNTDLGLGH NGVRISLNYF DGLPDPSLLN SLYSNELKLI FKSLLKRDET  60
   61 TKEKALMDLS NLISDFNQNE YFFNDIFLLC WSQIYAKLII SDYKVIRLQS HQITIMLVKS 120
  121 LRKKISKFLK DFIPLILLGT CELDYSVSKP SLNELTECFN KDPAKINALW AVFQEQLLNL 180
  181 VKEIVVNENE DTISDERYSS KEESEFRYHR VIASAVLLLI KLFVHNKDVS ERNSSSLKVI 240
  241 LSDESIWKLL NLKNGQNTNA YETVLRLIDV LYTRGYMPSH KNIMKLAVKK LLKSLTHITS 300
  301 KNILKVCPVL PSILNLLATL DDYEDGTIWS YDKSSKEKVL KFLSVSRTSP SPGFFNAVFA 360
  361 LYSSTKRHSF LDYYLEWLPF WQKSVQRLNE KGFSARNSAE VLNEFWTNFL KFAEDSSEER 420
  421 VKKMVESEIF NSLSCGKSLS EYTKLNQTLS GVFPPDKWER EIEDYFTSDE DIRKIKVSFE 480
  481 KNLFALLVTS PNNESAISRL FDFFVQLIET DPSNVFNKYD GVYDALNYFL DSDMIFLNGK 540
  541 IGKFINEIPT LVQESTYQNF AGIMAQYSNS KFFKMNTDAI TSLEDFFIVA LSFNLPKTII 600
  601 LATMNELDND IYQQLMKSDS LELELYIEDF MKNYKFDDSG EIFKGNNKFL NQRTITTLYR 660
  661 SAVANGQVEQ FCAVLSKLDE TFFSTLLLNT DFLSCALYEV SEDTNEKLFK LSLQLAKGNS 720
  721 EIANKLAQVI LQHAQVYFSP GAKEKYVTHA VELINGCNDT SQIFFPANAI EVFARYMPAI 780
  781 DYRSSLVSSL STNTHLLLTD DKPINLKNMQ KLIRYALFLD ALLDALPERV NNHIVAFITV 840
  841 VSELVTDYNC LSEEPNDLYY DFGHTFFKHG KVNLNFSDIV GNVIQPANGG DAMLTFDIAE 900
  901 SNSVYFFYYS RVLYKVLLNS IDTVSSTTLN GLLASVESFV TKTVRDQKST DKDYLLCAIL 960
  961 LLMFNRSNSK DEITKLRTLL ASQLIGIREV ELVDQEFKSL ALLNNLLDIP QADKQFVPIA1020
 1021 PQRLNMIFRS ILKWLDSDLA YEPSFSTVRL LLLDFFTKLM RFEGVRDMGI TAFELSERLL1080
 1081 ADSLSMCQID DTLYLLELRS SCLNLYETLS QGVSKNGEEI SEYGDEIQEN LIELMFLNFN1140
 1141 QERNNQVSTL FYQKLYKVIS SMELKKLESQ YKRIFEVVLN DKDIGSNINQ SRLLTTLLGS1200
 1201 LVVKTQQDII IEYELRIQKQ TGSDVDGSAS DNDVNSKFKL PQKLLQKVTD EVPKEYLEYE1260
 1261 NKNSFIKYLW YWHLILMYFK DTSYNMRQIF IEQLKEAGLI NRMFDFITDQ IDLRDTEFWK1320
 1321 QVDTKEISEY NIVGNNFSPY KEDIFEECKK LLGHTLYQLF NNVGCLTSIW WLNIKDRTLQ1380
 1381 NDIEKFVSEF ISPILIKNEF DDINSKMDRL TSNDDALTIK LNNITNEVKA SYLIDDQKLE1440
 1441 ISFKLPKNYP LTNIQVNGVS RVGISEQKWK QWIMSTQHVI TGMNGSVLDS LELFTKNVHL1500
 1501 QFSGFEECAI CYSILHAVDR KLPSKTCPTC KNKFHGACLY KWFRSSGNNT CPLCRSEIPF1560
 1561 RR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] MSA 3.008922 View MSA. No confident structure predictions are available.
    2 View Details [351..1449] deduced N/A No confident structure predictions are available.
    3 View Details [1450..1562] PSI-BLAST 3.0 Not-4 N-terminal RING finger domain
    4 View Details [1015..1226] deduced N/A No confident structure predictions are available.
    5 View Details [1227..1480] deduced N/A No confident structure predictions are available.
    6 View Details [1481..1562] PSI-BLAST 15.0 Solution structure of RING finger in RING finger protein 38

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • structural molecule activity
    		•  3.1588260193851 bayes_pls_golite062009
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.69616509670156 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.19067997822967 bayes_pls_golite062009
  • DNA binding
    		•  1.96172460362671 bayes_pls_golite062009
  • RNA binding
    		•  1.82387912821611 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • transcription factor activity
    		•  1.21493607378314 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.66737572008694 bayes_pls_golite062009
  • protein kinase activity
    		•  0.317596068919701 bayes_pls_golite062009
  • mRNA binding
    		•  0.242562403827776 bayes_pls_golite062009
  • transcription activator activity
    		•  0.142253868848261 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0926408709390653 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0799207008328691 bayes_pls_golite062009
  • kinase activity
    		•  0.0378340928609381 bayes_pls_golite062009
  • transcription factor binding
    		•  8.79739237675814E-4 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle