Protein Overview: ZRC1

General Information:
Name(s) found:	ZRC1 / YMR243C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|736309\|emb\|CAA88653.1\| Zrc1p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323899\|ref\|NP_013970.1\| Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm; Zrc1p [Saccharomyces cere [NCBI NR] gi\|51013877\|gb\|AAT93232.1\| YMR243C [Saccharomyces cerevisiae] [NCBI NR] gi\|1353181\|sp\|P20107.2\|ZRC1_YEAST RecName: Full=Zinc/cadmium resistance protein [NCBI NR] pir\|\|S56057 heavy metal ion resistance protein ZRC1 - yeast (Saccharomyces cerevisiae) [NCBI NR] Zinc/cadmium resistance protein OS=Saccharomyces cerevisiae GN=ZRC1 PE=1 SV=2 [Swiss-Prot] ZRC1 Vacuolar transporter of zinc (and possibly other metals) [mips] Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm [SGD] ZRC1, Chr XIII from 754837-756165, reverse complement [yeast_orfs2] Chr XIII from 754837-756165, reverse complement [yeastorf3.fasta] Chr XIII from 756165-754837, reverse complement [yeastorf5.fasta] (P20107) Zinc/cadmium resistance protein [4932.FASTACCERV.txt] ZRC1 SGDID:S0004856, Chr XIII from 756165-754837, reverse complement, Verified ORF [yeastflysequest.fasta] Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm [Saccharomyces cerevisiae]gi\|51013877\|gb\|AAT93232.1\| [nrdb_11152004_Chlamydomonas] ZRC1 SGDID:S000004856, Chr XIII from 756165-754837, reverse complement, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden i [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Zrc1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Zinc/cadmium resistance protein [nr-271106-contam.fasta] YMR243C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm; Zrc1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ZRC1 SGDID:S000004856, Chr XIII from 756165-754837, reverse complement, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Zinc/cadmium resistance protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZRC1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ZRC1 SGDID:S000004856, Chr XIII from 756166-754838, Genome Release 64-1-1, reverse complement, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm" [yeast-030211-contam.fasta] ZRC1 SGDID:S000004856, Chr XIII from 756166-754838, Genome Release 64-2-1, reverse complement, Verified ORF, "Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YMR243C SGDID:S000004856, Chr XIII from 756166-754838, Genome Release 64-1-1, reverse complement, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	442 amino acids
Gene Ontology:
Cellular Component:	fungal-type vacuole [IDA]
Biological Process:	cobalt ion transport [NAS] zinc ion transport [NAS] glutathione metabolic process [NAS] cellular zinc ion homeostasis [IMP]
Molecular Function:	zinc ion transmembrane transporter activity [IMP] di-, tri-valent inorganic cation transmembrane transporter activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MITGKELRII SLLTLDTVFF LLEITIGYMS HSLALIADSF HMLNDIISLL VALWAVDVAK  60
   61 NRGPDAKYTY GWKRAEILGA LINAVFLIAL CFSIMIEALQ RLIEPQEIQN PRLVLYVGVA 120
  121 GLISNVVGLF LFHDHGSDSL HSHSHGSVES GNNDLDIESN ATHSHSHASL PNDNLAIDED 180
  181 AISSPGPSGQ IGEVLPQSVV NRLSNESQPL LNHDDHDHSH ESKKPGHRSL NMHGVFLHVL 240
  241 GDALGNIGVI AAALFIWKTE YSWRYYSDPI VSLIITIIIF SSALPLSRRA SRILLQATPS 300
  301 TISADQIQRE ILAVPGVIAV HDFHVWNLTE SIYIASIHVQ IDCAPDKFMS SAKLIRKIFH 360
  361 QHGIHSATVQ PEFVSGDVNE DIRRRFSIIA GGSPSSSQEA FDSHGNTEHG RKKRSPTAYG 420
  421 ATTASSNCIV DDAVNCNTSN CL

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		BPT1 CCC1 COT1 VMA6 VMA9 ZRC1 ZRT3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	VAM3	Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control).	Hao Xu, et al. (2010)
View Run	VAM3	Sample: HX14 - mixture in detergent (control).	Hao Xu, et al. (2010)
View Run	VAM3	hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)
View Run	VAM3	hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	ZRC1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..442]	Pfam	69.259637	Cation efflux family No confident structure predictions are available.
2	View Details	[72..442]	PSI-BLAST	47.522879	No description for 2qfiA was found.

Protein Overview: ZRC1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: