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Protein Overview: SKY1

General Information:
Name(s) found: SKY1 / YMR216C [SGD]
Description(s) found:
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  • gi|854468|emb|CAA89931.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323872|ref|NP_013943.1| SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1; Sky1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2499619|sp|Q03656.1|SKY1_YEAST RecName: Full=Serine/threonine-protein kinase SKY1; Short=SRPK [NCBI NR]
  • pir||S55098 probable membrane protein YMR216c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Serine/threonine-protein kinase SKY1 OS=Saccharomyces cerevisiae GN=SKY1 PE=1 SV=1 [Swiss-Prot]
  • (Q03656) Probable serine/threonine-protein kinase YMR216C (EC 2.7.1.37) [Swiss-Prot]
  • SKY1 Protein serine kinase [mips]
  • SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 [SGD]
  • SKY1, Chr XIII from 698810-701038, reverse complement [yeast_orfs2]
  • Chr XIII from 698810-701038, reverse complement [yeastorf3.fasta]
  • Chr XIII from 701038-698810, reverse complement [yeastorf5.fasta]
  • (Q03656) Probable serine/threonine-protein kinase YMR216C (EC 2.7.1.-) [4932.FASTACCERV.txt]
  • SKY1 SGDID:S0004829, Chr XIII from 701038-698810, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Protein serine kinase with similarity to human SRPK1, which is a serine kinase that specifically phosphoryates arginine-serine rich domains found in the SR family of splicing factors [Saccharomyces cerevisiae]gi|854468|emb|CAA89931.1| unknown [Saccharomy [nrdb_11152004_Chlamydomonas]
  • SKY1 SGDID:S000004829, Chr XIII from 701038-698810, reverse complement, Verified ORF, "SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Serine/threonine-protein kinase SKY1 (SRPK) [nr-271106-contam.fasta]
  • SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1; Sky1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Serine/threonine-protein kinase SKY1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SKY1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SKY1 SGDID:S000004829, Chr XIII from 701039-698811, Genome Release 64-1-1, reverse complement, Verified ORF, "SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1" [yeast-030211-contam.fasta]
  • SKY1 SGDID:S000004829, Chr XIII from 701039-698811, Genome Release 64-2-1, reverse complement, Verified ORF, "SR protein kinase (SRPK); involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1" [20141208_orf_trans.fasta]
  • YMR216C SGDID:S000004829, Chr XIII from 701039-698811, Genome Release 64-1-1, reverse complement, Verified ORF, "SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 742 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: positive regulation of protein import into nucleus [IMPLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    regulation of cell size [IMPLink to PubMed article]
    mRNA splice site selection [IGILink to PubMed article]
    cellular cation homeostasis [IMPLink to PubMed article]
    cellular ion homeostasis [IMPLink to PubMed article]
    Molecular Function: protein kinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSSINYPGF VTKSAHLADT STDASISCEE ATSSQEAKKN FFQRDYNMMK KAPAPTKSKL  60
   61 SLALQTSKSS SSANGTVQED TSSKTEDFST KSIKKKPDSG VESHVSIQSD SGPQSDSDLD 120
  121 SDSSISSCDE RNEESLKDYR PGGYHPAFKG EPYKDARYIL VRKLGWGHFS TVWLAKDMVN 180
  181 NTHVAMKIVR GDKVYTEAAE DEIKLLQRVN DADNTKEDSM GANHILKLLD HFNHKGPNGV 240
  241 HVVMVFEVLG ENLLALIKKY EHRGIPLIYV KQISKQLLLG LDYMHRRCGI IHTDIKPENV 300
  301 LMEIGDVEGI VQMVEALDKQ KREAKRLQRH VSRSSDITAN DSSDEKWAEC QTSMPCGSSS 360
  361 NSKSRSIEKD LSKRCFRRPR RHTIITGSQP LPSPISSSNF FEMRAHFCGS SHNSFSSVSG 420
  421 NRNIPSSINN NSINNGIGIK NSNNSFLNSV PHSVTRMFIN EDSNDNNNND NSKNKNNNNN 480
  481 NSNNNNNEDI MNTPLHEEQL ADSLSTFDIS NISQSSDTNG PYISNTMDSN SNVSTDINSP 540
  541 ENLIQIKIAD LGNACWYDEH YTNSIQTREY RSPEVLLGAP WGCGADIWST ACLIFELITG 600
  601 DFLFEPDEGH SYTKDDDHIA QIIELLGELP SYLLRNGKYT RTFFNSRGLL RNISKLKFWP 660
  661 LEDVLTEKYK FSKDEAKEIS DFLSPMLQLD PRKRADAGGL VNHPWLKDTL GMEEIRVPDR 720
  721 ELYGSGSDIP GWFEEVRDHK RH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RPT4 SKY1 2 Unpublished Fields Lab Data
    View Screen SKY1 MCM6 2 Unpublished Fields Lab Data
    View Screen SKY1 RTC3 2 Unpublished Fields Lab Data
    View Screen SKY1 AIR1 2 Unpublished Fields Lab Data
    View Screen SKY1 MPC54 2 Unpublished Fields Lab Data
    View Screen UBP6 SKY1 1 Unpublished Fields Lab Data
    View Screen SKY1 FRE8 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SKY1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..129] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [130..372] PSI-BLAST 89.134302 Casein kinase-1, CK1
    3 View Details [373..424] deduced N/A No confident structure predictions are available.
    4 View Details [425..469]
    [488..503]    		 PSI-BLAST 1377.69897 Sky1p
    5 View Details [470..487]
    [504..560]    		 PSI-BLAST 1377.69897 Sky1p
    6 View Details [561..742] PSI-BLAST 1377.69897 Sky1p


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle