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Protein Overview: FRE8

General Information:
Name(s) found: FRE8 / YLR047C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 686 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    Biological Process: cellular metal ion homeostasis [IMPLink to PubMed article]
    Molecular Function: oxidoreductase activity, oxidizing metal ions [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLKSIVSWF KEHLPSFDVD VDKHFRTLRV RKYSQICLLI SFIIICVIIP LMNYLLLTDK  60
   61 FFKICHHLKH HVFNRRSWVH KTHMYHKQSL QLCLICFVFT SFFVIQGANG DLLEITKRMG 120
  121 RISVALMPPL LFLTLRPSPL PHTLYLALLP LHKWISRIVV LESILHTWFY LYYMYINDTL 180
  181 YVKMRKLPNI YGVIALGLFL LIAITSVRYA RRWSYRVFYY VHYVSTWLIL VFLHYHARPG 240
  241 ISYYTTLNVL ILTGQIVYRL HITNVTRVTI VPISSSLSLL EFPLTDLPKK PILPGGHLRI 300
  301 NIYHRNFLRR FFSHLIPFQH PFTIASIPSD NLVRLIIRNG HFPLRTNEKY YITGAFEPEL 360
  361 SFISKPTVPF NITTKSSKNP FRNNSSALIN SPLNFLIKAQ RVFMCVGGSG ISFGLPLLRI 420
  421 LNFNGVNVRL LWVSRDYKDL EVLNHFKNNF EGMEIYISGT EGNEQDIEID YIDYHDCAAD 480
  481 INDEVRSISS SGRVSELGDN SMLSDGNPQP TEPNENTALL SKKSTLRNHH PPKTSDIPDI 540
  541 NADDEIDFTY AFSRSKSRKN TAQGTLTTHS SFNGSSVFRQ PKIIEPPAQD PCLEAAPKKI 600
  601 RIPAGVKVFF GRPTLGDKDY EWCLQTECDA ETDSIQCCRW ANQGRDHAEY LSQVWVLAAG 660
  661 PRGLIESTKR WATDGGLHFH GESFAL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) AAC3 FRE8 PUF2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] deduced N/A No confident structure predictions are available.
    2 View Details [143..264] MSA 2.312979 View MSA. No confident structure predictions are available.
    3 View Details [265..393] PSI-BLAST 40.69897 cytochrome b5 reductase
    4 View Details [394..571] PSI-BLAST 40.69897 cytochrome b5 reductase
    5 View Details [572..686] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • cation transmembrane transporter activity
    		•  3.03953772177035 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.97347219787596 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.75731726445742 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.59951851289794 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.29266587906929 bayes_pls_golite062009
  • binding
    		•  0.979727257352345 bayes_pls_golite062009
  • protein binding
    		•  0.291685656235254 bayes_pls_golite062009
    3
    Term Confidence Notes
  • binding
    		•  0.923528499740225 bayes_pls_golite062009
  • protein binding
    		•  0.144900113694048 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle