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View Structure Prediction Details

Protein: FRE8
Organism: Saccharomyces cerevisiae
Length: 686 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRE8.

Description E-value Query
Range
Subject
Range
FRE8 - Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion m...
FRE8_YEAST - Probable ferric reductase transmembrane component 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 ...
0.0 [1..686] [1..686]
gi|17384016 - gi|17384016|emb|CAC87256.1| NADPH oxidase [Nicotiana tabacum]
0.0 [28..526] [331..925]
RBOHB_SOLTU - Respiratory burst oxidase homolog protein B OS=Solanum tuberosum GN=RBOHB PE=1 SV=1
0.0 [28..526] [254..830]
RBOHC_ARATH - Respiratory burst oxidase homolog protein C OS=Arabidopsis thaliana GN=RBOHC PE=2 SV=2
0.0 [28..526] [282..868]
gi|8131846, gi|8... - gi|8131890|gb|AAF73124.1|AF148534_1 whitefly-induced gp91-phox [Lycopersicon esculentum], gi|8131846...
0.0 [28..526] [301..901]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [28..526] [320..907]

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Predicted Domain #1
Region A:
Residues: [1-142]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNLKSIVSWF KEHLPSFDVD VDKHFRTLRV RKYSQICLLI SFIIICVIIP LMNYLLLTDK  60
   61 FFKICHHLKH HVFNRRSWVH KTHMYHKQSL QLCLICFVFT SFFVIQGANG DLLEITKRMG 120
  121 RISVALMPPL LFLTLRPSPL PH

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [143-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TLYLALLPLH KWISRIVVLE SILHTWFYLY YMYINDTLYV KMRKLPNIYG VIALGLFLLI  60
   61 AITSVRYARR WSYRVFYYVH YVSTWLILVF LHYHARPGIS YYTTLNVLIL TGQIVYRLHI 120
  121 TN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
cation transmembrane transporter activity 3.03953772177035 bayes_pls_golite062009
ion transmembrane transporter activity 2.97347219787596 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 2.75731726445742 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.59951851289794 bayes_pls_golite062009
substrate-specific transporter activity 2.29266587906929 bayes_pls_golite062009
binding 0.979727257352345 bayes_pls_golite062009
protein binding 0.291685656235254 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [265-393]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VTRVTIVPIS SSLSLLEFPL TDLPKKPILP GGHLRINIYH RNFLRRFFSH LIPFQHPFTI  60
   61 ASIPSDNLVR LIIRNGHFPL RTNEKYYITG AFEPELSFIS KPTVPFNITT KSSKNPFRNN 120
  121 SSALINSPL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1ib0A_
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.923528499740225 bayes_pls_golite062009
protein binding 0.144900113694048 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [394-571]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFLIKAQRVF MCVGGSGISF GLPLLRILNF NGVNVRLLWV SRDYKDLEVL NHFKNNFEGM  60
   61 EIYISGTEGN EQDIEIDYID YHDCAADIND EVRSISSSGR VSELGDNSML SDGNPQPTEP 120
  121 NENTALLSKK STLRNHHPPK TSDIPDINAD DEIDFTYAFS RSKSRKNTAQ GTLTTHSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1ib0A_
Description: cytochrome b5 reductase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [572-686]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FNGSSVFRQP KIIEPPAQDP CLEAAPKKIR IPAGVKVFFG RPTLGDKDYE WCLQTECDAE  60
   61 TDSIQCCRWA NQGRDHAEYL SQVWVLAAGP RGLIESTKRW ATDGGLHFHG ESFAL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle