Protein Overview: COG8

General Information:
Name(s) found:	COG8 / YML071C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323569\|ref\|NP_013640.1\| Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog8p [Saccharomyces [NCBI NR] gi\|2497081\|sp\|Q04632.1\|COG8_YEAST RecName: Full=Conserved oligomeric Golgi complex subunit 8; Short=COG complex subunit 8; AltName: Full=Component of oligomeric Golgi complex 8 [NCBI NR] pir\|\|S48326 hypothetical protein YML071c - yeast (Saccharomyces cerevisiae) [NCBI NR] (Q04632) DOR1 protein [Swiss-Prot] Conserved oligomeric Golgi complex subunit 8 OS=Saccharomyces cerevisiae GN=COG8 PE=1 SV=1 [Swiss-Prot] COG8 Conserved oligomeric golgi complex [mips] Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [SGD] YML071C, Chr XIII from 129749-131572, reverse complement [yeast_orfs2] Chr XIII from 129749-131572, reverse complement [yeastorf3.fasta] Chr XIII from 131572-129749, reverse complement [yeastorf5.fasta] COG8 SGDID:S0004536, Chr XIII from 131572-129749, reverse complement, Verified ORF [yeastflysequest.fasta] Cog8p [Saccharomyces cerevisiae]gi\|2497081\|sp\|Q04632\|DOR1_YEAST DOR1 proteingi\|2131825\|pir\|\|S48326 hypothetical protein YML071c - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] COG8 SGDID:S000004536, Chr XIII from 131572-129749, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of tran [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Conserved oligomeric Golgi complex subunit 8 (COG complex subunit 8) [nr-271106-contam.fasta] Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; Cog8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] COG8 SGDID:S000004536, Chr XIII from 131572-129749, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Conserved oligomeric Golgi complex subunit 8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=COG8 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] COG8 SGDID:S000004536, Chr XIII from 131572-129749, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [yeast-030211-contam.fasta] COG8 SGDID:S000004536, Chr XIII from 131572-129749, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [20141208_orf_trans.fasta] YML071C SGDID:S000004536, Chr XIII from 131572-129749, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	607 amino acids
Gene Ontology:
Cellular Component:	Golgi transport complex [IPI]
Biological Process:	intra-Golgi vesicle-mediated transport [IGI][IPI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELILNSLIS DDLTEEQKRL SLDFLQDILQ SNTKDYESYF SSRAVPGSIT EDIAEIDAEL  60
   61 SALDRKIRKT LLDNTSQIIG NILENDDRAQ LDDIAKSLEQ LWELDTNINK AADRNVTNDD 120
  121 INNESVSIDD FLEDDKEDND TGRIMTTESN NLARKKKEDE FHKALSRLRN RISTKEDDKD 180
  181 DIRSDTLVTV LENLDSITDL MELPFLARTC IRTGHYQEAV MLYTHTTSLR SRFPGSTIVD 240
  241 EVCEKVLNEI STTMLSGLVK LLSTNVSVNS LKKILQYLNS IPPFDGKTNK SLLSVFLAMR 300
  301 YKFITDEIAS YPLDVESSNE SLIEMMVKRK IEVLREHVYM SLNVFLKSFL YDTNDLEIPF 360
  361 PEELESTVLR INGTNEEKEI EEKEKETKKE EYQKQDSVAN NEEDVTENKS IEDVQEEVQG 420
  421 KVEGEDDGAE RKTENEIENE TVNKTEDKAE KEKEEEVNTK DNKAEKEEEE INKVEVTPEE 480
  481 PSKSIDNKAE KEEEEINKVE VTPEEPSKKI RTSKRENKIP TNAVMLQFVD KCITYVLKDL 540
  541 TRGLNSIKLS DSVCLQLVYC SFRLCDLNRN YHHLFLKKIN DTSLFTTEQL ARAIDKRAEL 600
  601 ASKYIYS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8
View Details	(MIPS) Mewes HW, et al. (2004)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8
View Details	Krogan NJ, et al. (2006)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8
View Details	Gavin AC, et al. (2006)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8 IML1
View Details	Gavin AC, et al. (2002)		CCT4 CHC1 COG8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GUT1 IST1 PDC1 PRO1 RRP40 RRP46 SUI2 SUI3 XKS1
View Details	Qiu et al. (2008)		COG1 COG2 COG3 COG4 COG5 COG6 COG7 COG8

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	BEM1	COG8	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	COG8	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..306]	PSI-BLAST	2.30103	Heavy meromyosin subfragment
2	View Details	[307..607]	ORFEUS	12.26	RBP1

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2