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Protein Overview: SEC39

General Information:
Name(s) found: SEC39 / YLR440C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 709 amino acids

    Gene Ontology:
    Cellular Component: nuclear envelope [IDALink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: secretory pathway [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLEEQLYLLA CIFASRADTR NIKKLSTRLG SQSKYLEILC VLWPELDDPK NLLFLRELEE  60
   61 EVQSPEGEET TDEDVIVELL ESDSSLIPLI ESDTTTRSNR YHELQEFISK KLNNKTLENF 120
  121 EEWLRERILI CNEMIPETPL LYSVLWETAK SKVLSTKFIG WVEGVLKPLD HLNKRLHLIF 180
  181 KINEWEKMPD SELFKIIFDG VEDMQGYIGI ADVIEDELAP TLSYGKKWET FITEFFNKQQ 240
  241 FSLKSDTNYQ LFIKLYYSLE KGVKDNSEAS RKLQSNVVDI LFHNSENLFN LSSLTHKLDE 300
  301 LWSILSGFPD EITIEEQKTI TALEMKQFME FFIKCSTKFS FKEIFAITQE EESAQLAHFS 360
  361 SLCHEEFNKA NEISSFLQAM YETVLDISKD DKIFTRISMD EKLYSILEIL LQMNEFAYIE 420
  421 AIIERFDYSN NTQIYELLVK FFWHFFNNAS NGLRKEPEMK KASQTLQIIQ KHMSQRAGTN 480
  481 LTKLEVLLEI SDKLSHYSIN LNKSHNGARD TAFKPSNILE YRDCPLDIIS NLLELNPRLY 540
  541 KDLPTTKSLL FGIYDSLSIN REGQTGKVEV DLMVLHIDYA LVNLDFGTAY ELGKQVFEIC 600
  601 QEAGQHMMKA LGDEHWLTFY QMGKFVDPNW VDNEIPTEII VLQMSILGRL LEVCPLEEVE 660
  661 IVTSQWSTLE LELSARDLVK DKYALDGQND NKSKVGGIAR EIFHNVTNF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) DSL1 SEC22 SEC39 TIP20 UFE1 USE1 YKT6
    View Details Gavin AC, et al. (2006) DSL1 SEC39 TIP20 UFE1 USE1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC39 and SPC42 Hazbun TR, et al. (2003)
    View Data SEC39 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..285] Pcons 1.67 Importin beta
    2 View Details [286..389] Pcons 1.67 Importin beta
    3 View Details [390..498] Pcons 1.67 Importin beta
    4 View Details [499..709] Pcons 1.67 Importin beta


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle