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Protein Overview: SEC61

General Information:
Name(s) found: SEC61 / YLR378C [SGD]
Description(s) found:
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  • gi|6323411|ref|NP_013482.1| Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein imp [NCBI NR]
  • gi|609428|gb|AAB67276.1| Sec61p: membrane component of ER protein translocation apparatus [Saccharomyces cerevisiae] [NCBI NR]
  • gi|4447|emb|CAA44215.1| SEC61 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|417751|sp|P32915.1|SC61A_YEAST RecName: Full=Protein transport protein SEC61; AltName: Full=Sec61 complex subunit SEC61; AltName: Full=Sec61 complex subunit alpha [NCBI NR]
  • pir||A60043 endoplasmic reticulum insertion protein SEC61 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Protein transport protein SEC61 OS=Saccharomyces cerevisiae GN=SEC61 PE=1 SV=1 [Swiss-Prot]
  • (P32915) Protein transport protein SEC61 alpha subunit [Swiss-Prot]
  • SEC61 ER protein-translocation complex subunit [mips]
  • Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER [SGD]
  • SEC61, Chr XII from 875735-877177, reverse complement [yeast_orfs2]
  • Chr XII from 875735-877177, reverse complement [yeastorf3.fasta]
  • Chr XII from 877177-875735, reverse complement [yeastorf5.fasta]
  • SEC61 SGDID:S0004370, Chr XII from 877177-875735, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Sec61p [Saccharomyces cerevisiae]gi|4447|emb|CAA44215.1| SEC61 [Saccharomyces cerevisiae]gi|417751|sp|P32915|S61A_YEAST Protein transport protein SEC61 alpha subunitgi|609428|gb|AAB67276.1| Sec61p: membrane component of ER protein translocation apparat [nrdb_11152004_Chlamydomonas]
  • SEC61 SGDID:S000004370, Chr XII from 877177-875735, reverse complement, Verified ORF, "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of th [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER; Sec61p [Sacchar [nr-271106-contam.fasta]
  • Sec61p: membrane component of ER protein translocation apparatus [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein transport protein SEC61 (Sec61 complex subunit SEC61) (Sec61 complex subunit alpha) [nr-271106-contam.fasta]
  • SEC61 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SEC61 SGDID:S000004370, Chr XII from 877177-875735, reverse complement, Verified ORF, "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein transport protein SEC61 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC61 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SEC61 SGDID:S000004370, Chr XII from 877178-875736, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER" [yeast-030211-contam.fasta]
  • SEC61 SGDID:S000004370, Chr XII from 877178-875736, Genome Release 64-2-1, reverse complement, Verified ORF, "Conserved ER protein translocation channel; essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms channel for SRP-dependent protein import; with Sec63 complex allows SRP-independent protein import into ER; involved in posttranslational soluble protein import into the ER, ERAD of soluble substrates, and misfolded soluble protein export from the ER" [20141208_orf_trans.fasta]
  • TR7145|c0_g1_i1|g.4983 ORF TR7145|c0_g1_i1|g.4983 TR7145|c0_g1_i1|m.4983 type:complete len:481 (+) TR7145|c0_g1_i1:213-1655(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR1424|c0_g1_i1|g.990 ORF TR1424|c0_g1_i1|g.990 TR1424|c0_g1_i1|m.990 type:complete len:481 (+) TR1424|c0_g1_i1:276-1718(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YLR378C SGDID:S000004370, Chr XII from 877178-875736, Genome Release 64-1-1, reverse complement, Verified ORF, "Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • asmbl_7042|g.5433 ORF asmbl_7042|g.5433 asmbl_7042|m.5433 type:complete len:481 (+) asmbl_7042:206-1648(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • asmbl_7750|g.5544 ORF asmbl_7750|g.5544 asmbl_7750|m.5544 type:complete len:481 (+) asmbl_7750:207-1649(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta]
  • ID=asmbl_7027|g.4409 ORF ID=asmbl_7027|g.4409 ID=asmbl_7027|m.4409 type:complete len:481 (+) ID=asmbl_7027:206-1648(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_7528|g.4726 ORF ID=asmbl_7528|g.4726 ID=asmbl_7528|m.4726 type:complete len:481 (+) ID=asmbl_7528:207-1649(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 480 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum lumen [IDALink to PubMed article]
    integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    Sec61 translocon complex [TASLink to PubMed article]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane, translocation [TASLink to PubMed article]
    protein targeting to ER [IMPLink to PubMed article]
    posttranslational protein targeting to membrane, translocation [TASLink to PubMed article]
    Molecular Function: protein transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSNRVLDLF KPFESFLPEV IAPERKVPYN QKLIWTGVSL LIFLILGQIP LYGIVSSETS  60
   61 DPLYWLRAML ASNRGTLLEL GVSPIITSSM IFQFLQGTQL LQIRPESKQD RELFQIAQKV 120
  121 CAIILILGQA LVVVMTGNYG APSDLGLPIC LLLIFQLMFA SLIVMLLDEL LSKGYGLGSG 180
  181 ISLFTATNIA EQIFWRAFAP TTVNSGRGKE FEGAVIAFFH LLAVRKDKKR ALVEAFYRTN 240
  241 LPNMFQVLMT VAIFLFVLYL QGFRYELPIR STKVRGQIGI YPIKLFYTSN TPIMLQSALT 300
  301 SNIFLISQIL FQKYPTNPLI RLIGVWGIRP GTQGPQMALS GLAYYIQPLM SLSEALLDPI 360
  361 KTIVYITFVL GSCAVFSKTW IEISGTSPRD IAKQFKDQGM VINGKRETSI YRELKKIIPT 420
  421 AAAFGGATIG ALSVGSDLLG TLGSGASILM ATTTIYGYYE AAAKEGGFTK NLVPGFSDLM 480
  481

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) SBH1 SEC61 SSS1
    View Details Qiu et al. (2008) SBH1 SEC61 SEC62 SEC63 SEC66 SEC72 SSH1 SSS1 STT3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SEC61 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] MSA 1.110984 View MSA. No confident structure predictions are available.
    2 View Details [73..480] Pfam 12.017729 eubacterial secY protein No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ribonucleoprotein binding
    		•  5.96221631042313 bayes_pls_golite062009
  • protein transporter activity
    		•  5.55929343005534 bayes_pls_golite062009
  • transporter activity
    		•  3.32223562584466 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.22714325269757 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • macromolecule transmembrane transporter activity
    		•  2.12732472524264 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.76187269823414 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.67782980643723 bayes_pls_golite062009
  • binding
    		•  1.4562802789412 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.42890247609405 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.15847548838424 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.15316743403707 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.10003802565492 bayes_pls_golite062009
  • peptide transporter activity
    		•  1.01893828721893 bayes_pls_golite062009
  • protein binding
    		•  0.674651002700028 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle