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Protein Overview: URA6

General Information:
Name(s) found: URA6 / YKL024C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 204 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: 'de novo' pyrimidine base biosynthetic process [IDALink to PubMed article]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IDALink to PubMed article]
    Molecular Function: uridine kinase activity [IDALink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTAATTSQPA FSPDQVSVIF VLGGPGAGKG TQCEKLVKDY SFVHLSAGDL LRAEQGRAGS  60
   61 QYGELIKNCI KEGQIVPQEI TLALLRNAIS DNVKANKHKF LIDGFPRKMD QAISFERDIV 120
  121 ESKFILFFDC PEDIMLERLL ERGKTSGRSD DNIESIKKRF NTFKETSMPV IEYFETKSKV 180
  181 VRVRCDRSVE DVYKDVQDAI RDSL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ALA1 ARO1 DUG1 GDH1 HIS4 HIS6 HRD1 MET6 OYE2 RAD14 SCP160 SPE3 SPE4 TIM11 URA6 YLF2 YRB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YLR224W URA6 1 Unpublished Fields Lab Data
    View Screen APC5 URA6 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data URA6 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..204] PSI-BLAST 1157.69897 Uridylate kinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  5.63633783771436 bayes_pls_golite062009
  • nucleotide kinase activity
    		•  4.87013305162694 bayes_pls_golite062009
  • phosphotransferase activity, phosphate group as acceptor
    		•  4.71956130169341 bayes_pls_golite062009
  • adenylate kinase activity
    		•  3.67594732794865 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  2.29455092461489 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.39044805677656 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.27520023113176 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.1237520329736 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.03581449013603 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • guanylate kinase activity
    		•  0.98934362137863 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.940135818362306 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.738234102557832 bayes_pls_golite062009
  • motor activity
    		•  0.68122766055454 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.569910969126728 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.568840867400671 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.568779924702229 bayes_pls_golite062009
  • nucleotide binding
    		•  0.564275755355315 bayes_pls_golite062009
  • CTP synthase activity
    		•  0.554689818807922 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.48522137429998 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • formate-tetrahydrofolate ligase activity
    		•  0.21533099279384 bayes_pls_golite062009
  • ATP binding
    		•  0.1860481660648 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.152859582615242 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138615225841109 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0558641287316701 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle