Protein Overview: SWD2

General Information:
Name(s) found:	SWD2 / YKL018W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322834\|ref\|NP_012907.1\| Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination; [NCBI NR] gi\|549660\|sp\|P36104.1\|SWD2_YEAST RecName: Full=COMPASS component SWD2; AltName: Full=Complex proteins associated with SET1 protein SWD2; AltName: Full=Set1C component SWD2 [NCBI NR] pir\|\|S37831 hypothetical protein YKL018w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486009\|emb\|CAA81853.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|45270078\|gb\|AAS56420.1\| YKL018W [Saccharomyces cerevisiae] [NCBI NR] COMPASS component SWD2 OS=Saccharomyces cerevisiae GN=SWD2 PE=1 SV=1 [Swiss-Prot] SWD2 Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [mips] Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination [SGD] YKL018W, Chr XI from 403740-404729 [yeast_orfs2] Chr XI from 403740-404729 [yeastorf3.fasta] (P36104) Hypothetical 37.1 kDa Trp-Asp repeats containing protein in RAM2-ATP7 intergenic region [4932.FASTACCERV.txt] SWD2 SGDID:S0001501, Chr XI from 403745-404734, Verified ORF [yeastflysequest.fasta] Subunit of the COMPASS complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [Saccharomyces cerevisiae]gi\|486009\|emb\|CAA81853.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|539149\|pir\|\|S378 [nrdb_11152004_Chlamydomonas] (P36104) WD repeat protein SWD2 [cerv4932.FASTAC] SWD2 SGDID:S000001501, Chr XI from 403745-404734, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates ubiquitinated histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a com [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] SWD2 SGDID:S000001501, Chr XI from 403745-404734, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved [yeast-contam.fasta] YKL018W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] COMPASS component SWD2 (Complex proteins associated with SET1 protein SWD2) (Set1C component SWD2) [nr-271106-contam.fasta] Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination; Swd2p [Saccharomyces cerevi [nr-271106-contam.fasta] SWD2 SGDID:S000001501, Chr XI from 403745-404734, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination" [yeast-bovrabprots.fasta] [chemostatdb.fasta] COMPASS component SWD2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SWD2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SWD2 SGDID:S000001501, Chr XI from 404102-405091, Genome Release 64-1-1, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination" [yeast-030211-contam.fasta] SWD2 SGDID:S000001501, Chr XI from 404102-405091, Genome Release 64-2-1, Verified ORF, "Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex; required for Set1C stability and optimal activity; COMPASS methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination" [20141208_orf_trans.fasta] TR445\|c0_g1_i1\|g.221 ORF TR445\|c0_g1_i1\|g.221 TR445\|c0_g1_i1\|m.221 type:complete len:330 (+) TR445\|c0_g1_i1:42-1031(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] YKL018W SGDID:S000001501, Chr XI from 404102-405091, Genome Release 64-1-1, Verified ORF, "Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_6687\|g.4990 ORF asmbl_6687\|g.4990 asmbl_6687\|m.4990 type:complete len:330 (+) asmbl_6687:50-1039(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_6706\|g.4032 ORF ID=asmbl_6706\|g.4032 ID=asmbl_6706\|m.4032 type:complete len:330 (+) ID=asmbl_6706:50-1039(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	329 amino acids
Gene Ontology:
Cellular Component:	Set1C/COMPASS complex [IPI ] mRNA cleavage and polyadenylation specificity factor complex [IPI]
Biological Process:	termination of RNA polymerase II transcription, poly(A)-coupled [IPI] termination of RNA polymerase II transcription, poly(A)-independent [IPI] histone methylation [IDA ] telomere maintenance [IMP] mRNA 3'-end processing [IMP] snoRNA 3'-end processing [IMP]
Molecular Function:	histone methyltransferase activity (H3-K4 specific) [IDA ]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTVSINKPN LLKFKHVKSF QPQEKDCGPV TSLNFDDNGQ FLLTSSSNDT MQLYSATNCK  60
   61 FLDTIASKKY GCHSAIFTHA QNECIYSSTM KNFDIKYLNL ETNQYLRYFS GHGALVNDLK 120
  121 MNPVNDTFLS SSYDESVRLW DLKISKPQVI IPSLVPNCIA YDPSGLVFAL GNPENFEIGL 180
  181 YNLKKIQEGP FLIIKINDAT FSQWNKLEFS NNGKYLLVGS SIGKHLIFDA FTGQQLFELI 240
  241 GTRAFPMREF LDSGSACFTP DGEFVLGTDY DGRIAIWNHS DSISNKVLRP QGFIPCVSHE 300
  301 TCPRSIAFNP KYSMFVTADE TVDFYVYDE

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRE2 CFT1 CFT2 FIP1 GLC7 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SDC1 SET1 SHG1 SPP1 SSU72 SWD1 SWD2 SWD3 SYC1 YSH1 YTH1
View Details	Krogan NJ, et al. (2006)		AIM1 CFT1 CFT2 ECM21 FIP1 GIP4 MPE1 PAP1 PFS2 PTA1 PTI1 REF2 SSU72 SWD2 SYC1 YBL010C YLR358C YSH1 YTH1
View Details	Qiu et al. (2008)		BRE2 CFT1 HRP1 NOP1 PAP1 PTI1 RNA15 SDC1 SET1 SHG1 SWD1 SWD2 SWD3 YSH1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SWD2	YMR111C	2	Unpublished Fields Lab Data
View Screen	SWD2	MVP1	1	Unpublished Fields Lab Data
View Screen	SWD2	HRP1	1	Unpublished Fields Lab Data
View Screen	NAF1	SWD2	1	Hazbun TR, et al. (2003)
View Screen	DOT1	SWD2	1	Unpublished Fields Lab Data
View Screen	RGD2	SWD2	1	Unpublished Fields Lab Data
View Screen	SWD2	FOB1	1	Unpublished Fields Lab Data
View Screen	SWD2	REF2	1	Unpublished Fields Lab Data
View Screen	SWD2	YGL052W	1	Unpublished Fields Lab Data
View Screen	SWD2	PTI1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..329]	PSI-BLAST	111.54902	beta1-subunit of the signal-transducing G protein heterotrimer

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2