Protein Overview: RPE1

General Information:
Name(s) found:	RPE1 / YJL121C [SGD]
Description(s) found: Found 31 descriptions. SHOW ALL	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress [SGD]
Organism:	Saccharomyces cerevisiae
Length:	238 amino acids
Gene Ontology:
Cellular Component:	cytosol [TAS]
Biological Process:	pentose-phosphate shunt [IMP]
Molecular Function:	ribulose-phosphate 3-epimerase activity [IDA][IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKPIIAPSI LASDFANLGC ECHKVINAGA DWLHIDVMDG HFVPNITLGQ PIVTSLRRSV  60
   61 PRPGDASNTE KKPTAFFDCH MMVENPEKWV DDFAKCGADQ FTFHYEATQD PLHLVKLIKS 120
  121 KGIKAACAIK PGTSVDVLFE LAPHLDMALV MTVEPGFGGQ KFMEDMMPKV ETLRAKFPHL 180
  181 NIQVDGGLGK ETIPKAAKAG ANVIVAGTSV FTAADPHDVI SFMKEEVSKE LRSRDLLD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	RPA135	his-HA tag on RPA135	Schneider, DA, et al. (2006)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CDC48	RPE1	1	Unpublished Fields Lab Data
View Screen	APC5	RPE1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RPE1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..238]	PSI-BLAST	421.94696	D-ribulose-5-phosphate 3-epimerase

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
ribulose-phosphate 3-epimerase activity	3.28372503209224	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
intramolecular oxidoreductase activity	1.86158562896415	bayes_pls_golite062009
intramolecular oxidoreductase activity, interconverting aldoses and ketoses	1.36492964250879	bayes_pls_golite062009
isomerase activity	0.935800409577999	bayes_pls_golite062009
racemase and epimerase activity, acting on carbohydrates and derivatives	0.764608070506109	bayes_pls_golite062009
orotidine-5'-phosphate decarboxylase activity	0.758594564254247	bayes_pls_golite062009
binding	0.595171555788202	bayes_pls_golite062009
racemase and epimerase activity	0.288948763149344	bayes_pls_golite062009
carboxy-lyase activity	0.1100847613283	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.62

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2