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Protein Overview: MRS1

General Information:
Name(s) found: MRS1 / YIR021W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 363 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][TASLink to PubMed article]
    Biological Process: Group I intron splicing [IDALink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]
    [NOT]endodeoxyribonuclease activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPKNITRSV IPAIDLYCRK ANFKTLKSLS MILGSKKEWY DTKKAPLRTF LVSRCGIFEQ  60
   61 LRGRLVEDGK VNLFSVFLTN DSFSFCKMTV DDKFNTSLVD WQKIPFDSTF ATDRRQNISL 120
  121 LPVDTLFATE KIISILGVSP NMTNLVSIER ERSDLVDFNC KLQSNILEHL LYAKCQGVYV 180
  181 TSTNEKARLL AAVCNPEFID TFWCELTPIR VSLKENPSIS VPREYQMYDP VVRATIKEVV 240
  241 TKRLLRSAFD NDIDPLMCLH LDKGWKLKFP ILSSTTGLNF SLKDCLSLDT GKDASDMTEV 300
  301 FLATMESSKV LRTYSNLVDI VMKDNGRLDS GVLKQFNDYV KQEKLNLQHF QAGSSKFLKG 360
  361 AKI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) BI4 CBP6 MRS1 MRS2 MRS3 MRS4 MSS1 MSS116 MSS18 MTF2 NAM2 PET54 TIM10
    View Details Krogan NJ, et al. (2006) MRS1 RPL42B, RPL42A SEO1 SPE2
    View Details Qiu et al. (2008) BI3 BI4 MRS1 MRS3 PET54

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CIA1 MRS1 2 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MRS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] deduced N/A No confident structure predictions are available.
    2 View Details [70..218] PSI-BLAST 4.0 Mitochondrial resolvase ydc2 N-terminal domain; Mitochondrial resolvase ydc2 catalytic domain
    3 View Details [219..363] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nuclease activity
    		•  2.26556994009539 bayes_pls_golite062009
    		• 2.00836055708423 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.78000986678433 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.32264233824256 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.27522285482764 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.20586272399219 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.15524113948715 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.05288004668073 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.99953538134208 bayes_pls_golite062009
  • exonuclease activity
    		•  0.967966366451269 bayes_pls_golite062009
  • DNA binding
    		•  0.943022297191079 bayes_pls_golite062009
  • binding
    		•  0.925646122805083 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.830848153280868 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.681014317532767 bayes_pls_golite062009
  • endonuclease activity
    		•  0.635517699603511 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.4571735090405 bayes_pls_golite062009
  • transcription factor activity
    		•  0.350780284864953 bayes_pls_golite062009
  • RNA binding
    		•  0.239100354404122 bayes_pls_golite062009
  • protein binding
    		•  0.035326007863533 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.016619833072142 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle