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Protein Overview: MRS4

General Information:
Name(s) found: MRS4 / YKR052C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 304 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: RNA splicing [IGILink to PubMed article]
    mitochondrial transport [ISSLink to PubMed article]
    mitochondrial iron ion transport [IDALink to PubMed article]
    Molecular Function: iron ion transmembrane transporter activity [IMPLink to PubMed article]
    surfactant activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNTSELSIAE EIDYEALPSH APLHSQLLAG AFAGIMEHSL MFPIDALKTR VQAAGLNKAA  60
   61 STGMISQISK ISTMEGSMAL WKGVQSVILG AGPAHAVYFG TYEFCKARLI SPEDMQTHQP 120
  121 MKTALSGTIA TIAADALMNP FDTVKQRLQL DTNLRVWNVT KQIYQNEGFA AFYYSYPTTL 180
  181 AMNIPFAAFN FMIYESASKF FNPQNSYNPL IHCLCGGISG ATCAALTTPL DCIKTVLQVR 240
  241 GSETVSIEIM KDANTFGRAS RAILEVHGWK GFWRGLKPRI VANIPATAIS WTAYECAKHF 300
  301 LMKN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) BI4 CBP6 MRS1 MRS2 MRS3 MRS4 MSS1 MSS116 MSS18 MTF2 NAM2 PET54 TIM10
    View Details Qiu et al. (2008) CBP6 MRS3 MRS4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MRS4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..304] ORFEUS 7.04 Peroxisomal acyl-CoA oxidase-II, domains 3 and 4; Peroxisomal acyl-CoA oxidase-II, domains 1 and 2


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.27

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle