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Protein Overview: MAS2

General Information:
Name(s) found: MAS2 / YHR024C [SGD]
Description(s) found:
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  • pir||ZPBY mitochondrial processing peptidase (EC 3.4.24.64) alpha chain precursor - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6321813|ref|NP_011889.1| Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; Mas2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|500696|gb|AAB68877.1| Mas2p: 53kDa subunit of the mitochondrial processing protease [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2949|emb|CAA31804.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|127288|sp|P11914.1|MPPA_YEAST RecName: Full=Mitochondrial-processing peptidase subunit alpha; AltName: Full=Alpha-MPP; Flags: Precursor [NCBI NR]
  • Mitochondrial-processing peptidase subunit alpha OS=Saccharomyces cerevisiae GN=MAS2 PE=1 SV=1 [Swiss-Prot]
  • MAS2 Processing peptidase, catalytic 53kDa (alpha) subunit, mitochondrial [mips]
  • Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [SGD]
  • MAS2, Chr VIII from 157735-159183, reverse complement [yeast_orfs2]
  • Chr VIII from 157735-159183, reverse complement [yeastorf3.fasta]
  • Chr VIII from 159183-157735, reverse complement [yeastorf5.fasta]
  • (P11914) Mitochondrial processing peptidase alpha subunit, mitochondrial precursor (EC 3.4.24.64) (Alpha-MPP) [4932.FASTACCERV.txt]
  • MAS2 SGDID:S0001066, Chr VIII from 159184-157736, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Larger subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [Saccharomyces cerevisiae]gi|2949|emb|CAA31804.1| unnamed protein product [Sacchar [nrdb_11152004_Chlamydomonas]
  • MAS2 SGDID:S000001066, Chr VIII from 159185-157737, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported prote [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MAS2 SGDID:S000001066, Chr VIII from 159185-157737, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Mas2p: 53kDa subunit of the mitochondrial processing protease [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mitochondrial-processing peptidase alpha subunit, mitochondrial precursor (Alpha-MPP) [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Larger subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins; Mas2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • MAS2 SGDID:S000001066, Chr VIII from 159185-157737, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" [yeast-bovrabprots.fasta]
  • MAS2 SGDID:S000001066, Chr VIII from 159185-157737, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease, essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Mitochondrial-processing peptidase subunit alpha OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAS2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MAS2 SGDID:S000001066, Chr VIII from 159192-157744, Genome Release 64-1-1, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" [yeast-030211-contam.fasta]
  • MAS2 SGDID:S000001066, Chr VIII from 159192-157744, Genome Release 64-2-1, reverse complement, Verified ORF, "Alpha subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" [20141208_orf_trans.fasta]
  • TR1132|c0_g1_i1|g.891 ORF TR1132|c0_g1_i1|g.891 TR1132|c0_g1_i1|m.891 type:complete len:483 (+) TR1132|c0_g1_i1:80-1528(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • YHR024C SGDID:S000001066, Chr VIII from 159192-157744, Genome Release 64-1-1, reverse complement, Verified ORF, "Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_8002|g.5009 ORF ID=asmbl_8002|g.5009 ID=asmbl_8002|m.5009 type:complete len:483 (+) ID=asmbl_8002:79-1527(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 482 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    mitochondrial processing peptidase complex [IDALink to PubMed article]
    Biological Process: protein processing involved in protein targeting to mitochondrion [IMPLink to PubMed article]
    Molecular Function: mitochondrial processing peptidase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNGVQRLY SNIARTDNFK LSSLANGLKV ATSNTPGHFS ALGLYIDAGS RFEGRNLKGC  60
   61 THILDRLAFK STEHVEGRAM AETLELLGGN YQCTSSRENL MYQASVFNQD VGKMLQLMSE 120
  121 TVRFPKITEQ ELQEQKLSAE YEIDEVWMKP ELVLPELLHT AAYSGETLGS PLICPRELIP 180
  181 SISKYYLLDY RNKFYTPENT VAAFVGVPHE KALELTEKYL GDWQSTHPPI TKKVAQYTGG 240
  241 ESCIPPAPVF GNLPELFHIQ IGFEGLPIDH PDIYALATLQ TLLGGGGSFS AGGPGKGMYS 300
  301 RLYTHVLNQY YFVENCVAFN HSYSDSGIFG ISLSCIPQAA PQAVEVIAQQ MYNTFANKDL 360
  361 RLTEDEVSRA KNQLKSSLLM NLESKLVELE DMGRQVLMHG RKIPVNEMIS KIEDLKPDDI 420
  421 SRVAEMIFTG NVNNAGNGKG RATVVMQGDR GSFGDVENVL KAYGLGNSSS SKNDSPKKKG 480
  481 WF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MAS1 MAS2
    View Details (MIPS) Mewes HW, et al. (2004) MAS1 MAS2
    View Details Krogan NJ, et al. (2006) ATG2 MAS1 MAS2
    View Details Gavin AC, et al. (2006) MAS1 MAS2
    View Details Gavin AC, et al. (2002) DIS3 ISW1 MAS1 MAS2 RRP4 SMC4
    View Details Ho Y, et al. (2002) MAS1 MAS2 MSH1 RNR3
    View Details Qiu et al. (2008) MAS1 MAS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MAS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147]
    [169..233]
    [381..406]    		 PSI-BLAST 10118.0 Mitochondrial processing peptidase (MPP) alpha chain
    2 View Details [148..168]
    [234..380]
    [407..482]    		 PSI-BLAST 10118.0 Mitochondrial processing peptidase (MPP) alpha chain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
    		•  10.0305725791312 bayes_pls_golite062009
  • ubiquinol-cytochrome-c reductase activity
    		•  10.0305725791312 bayes_pls_golite062009
  • metallopeptidase activity
    		•  7.31794755224524 bayes_pls_golite062009
  • metalloendopeptidase activity
    		•  7.31174048559335 bayes_pls_golite062009
  • peptidase activity
    		•  7.05972470989638 bayes_pls_golite062009
  • oxidoreductase activity, acting on diphenols and related substances as donors
    		•  6.64269017601856 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  6.57226784092621 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  4.17510847735476 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  4.03221088799464 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.89224384280888 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.48526983761385 bayes_pls_golite062009
  • endopeptidase activity
    		•  3.25021389096625 bayes_pls_golite062009
  • hydrolase activity
    		•  2.79262298779436 bayes_pls_golite062009
  • transporter activity
    		•  1.55442313420533 bayes_pls_golite062009
  • binding
    		•  1.51460850438647 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.40378628474509 bayes_pls_golite062009
  • catalytic activity
    		•  1.30647052031202 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.29599547747567 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.16717310870379 bayes_pls_golite062009
  • signal transducer activity
    		•  1.12122807250795 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.12122807250795 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.05022391589259 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.961854978876222 bayes_pls_golite062009
  • protein binding
    		•  0.236143103582996 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.11486391789734 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.077701103001661 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0688257218639591 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0662171656580391 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle