YRC Public Data Repository - Protein Structure Prediction

Protein:	MAS2
Organism:	Saccharomyces cerevisiae
Length:	482 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAS2.

Description	E-value	Query Range	Subject Range
MPPB_MOUSE - Mitochondrial-processing peptidase subunit beta OS=Mus musculus GN=Pmpcb PE=1 SV=1	0.0	[5..453]	[44..484]
gi\|3342006, gi\|4... - gi\|4758734\|ref\|NP_004270.1\| peptidase (mitochondrial processing) beta [Homo sapiens], gi\|3342006\|gb\|...	0.0	[5..453]	[44..484]
gi\|195570810, gi... - gi\|195570810\|ref\|XP_002103397.1\| GD18983 [Drosophila simulans], gi\|194199324\|gb\|EDX12900.1\| GD18983 ... gi\|220945206, gi... - gi\|220955020\|gb\|ACL90053.1\| CG3731-PA [synthetic construct], gi\|220945206\|gb\|ACL85146.1\| CG3731-PA [... gi\|195328891, gi... - gi\|195328891\|ref\|XP_002031145.1\| GM24191 [Drosophila sechellia], gi\|194120088\|gb\|EDW42131.1\| GM24191... CG3731-PB, CG3731-PA - This gene is referred to in FlyBase by the symbol Dmel\CG3731 (CG3731, FBgn0038271). It is a protein...	0.0	[5..454]	[27..466]
gi\|397699 - gi\|397699\|dbj\|BAA03007.1\| mitochondrial processing protease [Rattus norvegicus]	0.0	[5..453]	[42..482]
gi\|3889 - gi\|3889\|emb\|CAA32262.1\| processing protease [Saccharomyces cerevisiae]	0.0	[1..482]	[1..482]
gi\|12802327 - gi\|12802327\|gb\|AAK07827.1\|AF297643_1 mitochondrial processing peptidase beta subunit [Cucumis melo]	0.0	[13..450]	[88..520]
gi\|3659967, gi\|5... - gi\|5822457\|pdb\|2BCC\|A Chain A, Stigmatellin-Bound Cytochrome Bc1 Complex From Chicken, gi\|3660376\|pd...	0.0	[10..453]	[5..441]

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Predicted Domain #1

Region A:
Residues: [1-147]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLRNGVQRLY SNIARTDNFK LSSLANGLKV ATSNTPGHFS ALGLYIDAGS RFEGRNLKGC  60
   61 THILDRLAFK STEHVEGRAM AETLELLGGN YQCTSSRENL MYQASVFNQD VGKMLQLMSE 120
  121 TVRFPKITEQ ELQEQKLSAE YEIDEVW

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [169-233]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GSPLICPREL IPSISKYYLL DYRNKFYTPE NTVAAFVGVP HEKALELTEK YLGDWQSTHP  60
   61 PITKK

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [381-406]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NLESKLVELE DMGRQVLMHG RKIPVN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10118.0
Match:	1hr6A_
Description:	Mitochondrial processing peptidase (MPP) alpha chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor	10.0305725791312	bayes_pls_golite062009
ubiquinol-cytochrome-c reductase activity	10.0305725791312	bayes_pls_golite062009
metallopeptidase activity	7.31794755224524	bayes_pls_golite062009
metalloendopeptidase activity	7.31174048559335	bayes_pls_golite062009
peptidase activity	7.05972470989638	bayes_pls_golite062009
oxidoreductase activity, acting on diphenols and related substances as donors	6.64269017601856	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	6.57226784092621	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	4.17510847735476	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	4.03221088799464	bayes_pls_golite062009
oxidoreductase activity	3.89224384280888	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	3.48526983761385	bayes_pls_golite062009
endopeptidase activity	3.25021389096625	bayes_pls_golite062009
hydrolase activity	2.79262298779436	bayes_pls_golite062009
transporter activity	1.55442313420533	bayes_pls_golite062009
binding	1.51460850438647	bayes_pls_golite062009
transmembrane transporter activity	1.40378628474509	bayes_pls_golite062009
catalytic activity	1.30647052031202	bayes_pls_golite062009
substrate-specific transporter activity	1.29599547747567	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.16717310870379	bayes_pls_golite062009
signal transducer activity	1.12122807250795	bayes_pls_golite062009
molecular transducer activity	1.12122807250795	bayes_pls_golite062009
ion transmembrane transporter activity	1.05022391589259	bayes_pls_golite062009
cation transmembrane transporter activity	0.961854978876222	bayes_pls_golite062009
protein binding	0.236143103582996	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.11486391789734	bayes_pls_golite062009
pyrophosphatase activity	0.077701103001661	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0688257218639591	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0662171656580391	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [148-168]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPELVLPEL LHTAAYSGET L

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [234-380]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAQYTGGESC IPPAPVFGNL PELFHIQIGF EGLPIDHPDI YALATLQTLL GGGGSFSAGG  60
   61 PGKGMYSRLY THVLNQYYFV ENCVAFNHSY SDSGIFGISL SCIPQAAPQA VEVIAQQMYN 120
  121 TFANKDLRLT EDEVSRAKNQ LKSSLLM

[Run NCBI BLAST on this sequence.]

Region C:
Residues: [407-482]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EMISKIEDLK PDDISRVAEM IFTGNVNNAG NGKGRATVVM QGDRGSFGDV ENVLKAYGLG  60
   61 NSSSSKNDSP KKKGWF

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	10118.0
Match:	1hr6A_
Description:	Mitochondrial processing peptidase (MPP) alpha chain
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: