Protein Overview: YSC84

General Information:
Name(s) found:	YSC84 / YHR016C [SGD]
Description(s) found: Found 26 descriptions. SHOW ALL	Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	468 amino acids
Gene Ontology:
Cellular Component:	actin cortical patch [IDA]
Biological Process:	actin filament organization [IPI] endocytosis [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGINNPIPRS LKSETKKAAK VLRSFVKPNQ VFGADQVIPP YVLKRAKGLA IITVLKAGFL  60
   61 FSGRAGSGVI VARLKDGTWS APSAIAMAGA GAGGMVGVEL TDFVFILNSE EAVRSFSEFG 120
  121 TITLGGNVSV SAGPLGRSAE AAASASTGGV SAVFAYSKSK GLFAGVSVEG SAILERREAN 180
  181 RKFYGDNCTS KMILSGRVKV PPAADPLLRI LESRAFNFTR HDHDDNASGD DFYDDGQYSD 240
  241 NTSHYYDDIP DSFDSTDESS TRPNTRSSRR RGMSLGSRSR YDDDYDDDGY GRGRGYGDFD 300
  301 SEDEDYDYGR SPNRNSSRNR GPQIDRGTKP RANTRWEDDL YDRDTEYSRP NHSGRDYDNT 360
  361 RGNRRGYGRE RGYSLGHGPT HPSNMSNVDD LSHKMSKTGL GNESTATNSA TPTAVALYNF 420
  421 AGEQPGDLAF KKGDVITILK KSDSQNDWWT GRTNGKEGIF PANYVRVS

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		LSB3 YSC84
View Details	Krogan NJ, et al. (2006)		CLB1 CUE5 LSB3 RTT10 TRM7 YMR259C YSC84
View Details	Gavin AC, et al. (2002)		BSP1 BZZ1 CHC1 ECM25 END3 INP52 LAS17 LSB3 RAD51 SLA1 SLA2 STM1 SYP1 TFP1 VRP1 YPT7 YSC84
View Details	Ho Y, et al. (2002)		ABP1 ARP3 HXT7 SCP1 SPS1 TUP1 YSC84
View Details	Qiu et al. (2008)		COF1 CRN1 SAC6 SLA1 YSC84

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	GTS1	YSC84	2	Unpublished Fields Lab Data
View Screen	SLA2	YSC84	2	Drees BL, et al. (2001)
View Screen	SPT21	YSC84	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..80]	MSA	1.01298	View MSA. No confident structure predictions are available.
2	View Details	[81..413]	ORFEUS	9.31	RBP1
3	View Details	[414..468]	PSI-BLAST	111.325697	Growth factor receptor-bound protein 2 (GRB2), N- and C-terminal domains
4	View Details	[387..468]	PSI-BLAST	20.69897	No description for 2a08A was found.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2