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Protein Overview: YRF1-3, YRF1-7

General Information:
Name(s) found: YRF1-7 / YPL283C [SGD]
YRF1-3 / YGR296W [SGD]
Description(s) found:
Found 37 descriptions.
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  • Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [SGD]
  • Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1859 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: telomere maintenance via recombination [IGILink to PubMed article]
    Molecular Function: DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIENEQICT CIAQILHLLN SLIITFLDDD KTETGQSFVY IDGFLVKKHN NQHTIVNFET  60
   61 YKNKMKVSDR RKFEKANFDE FESALNNKND LVHCPSITLF ESIPTEVRSF YEDEKSGLIK 120
  121 VVKFRTGAMD RKRSFEKIVV SVMVGKNVQK FLTFVEDEPD FQGGPIPSKY LIPKKINLMV 180
  181 YTLFQVHTLK FNRKDYDTLS LFYLNRGYYN ELSFRVLERC YEIASARPND SSTMRTFTDF 240
  241 VSGTPIVRGL QKSTIRKYGY NLAPYMFLLL HVDELSIFSA YQASLPGEKK VDTERLKRDL 300
  301 CPRKPTEIKY FSQICNDMMN KKDRLGDILH IILRACALNF GAGPRGGAGD EEDRSITNEE 360
  361 PIIPSVDEHG LKVCKLRSPN TPRRLRKTLD AVKALLVSSC ACTARDLDIF DDNNGVAMWK 420
  421 WIKILYHEVA QETALKDSYR ITLVPSSDGV SVCGKLFNRE YVRGFYFACK AQFDNLWEEL 480
  481 NDCFYMPTVV DIASLILRNR EVLFREPKRG IDEYLENDSF LQMIPVKYRE IVLPKLRRDT 540
  541 NKMTAALKNK VTVAIDELTV PLMWMIHFAV GYPYRYPELQ LLAFAGPQRN VYVDDTTRRI 600
  601 QLYTDYNKNG SSEPRLKTLD GLTSDYVFYF VTVLRQMQIC ALGNSYDAFN HDPWMDVVGF 660
  661 EDPDQVTNRD ISRIVLYSYM FLNTAKGCLV EYATFRQYMR ELPKNAPQKL NFREMRQGLI 720
  721 ALGRHCVGSR FETDLYESAT SELMANHSVQ TGRNIYGVDS FSLTSVSGTT ATLLQERASE 780
  781 RWIQWLGLES DYHCSFSSTR NAEDVVAGEA ASSDHHQKIS RVTRKRPREP KSTNDILVAG 840
  841 QKLFGSSFEF RDLHQLRLCH EIYMADTPSV AVQAPPGYGK TELFHLPLIA LASKGDVKYV 900
  901 SFLFVPYTVL LANCMIRLSR CGCLNVAPVR NFIEEGCDGV TDLYVGIYDD LASTNFTDRI 960
  961 AAWENIVECT FRTNNVKLGY LIVDEFHNFE TEVYRQSQFG GITNLDFDAF EKAIFLSGTA1020
 1021 PEAVADAALQ RIGLTGLAKK SMDINELKRS EDLSRGLSSY PTRMFNLIKE KSEVPLGHVH1080
 1081 KIWKKVESQP EEALKLLLAL FEIEPESKAI VVASTTNEVE ELACSWRKYF RVVWIHGKLG1140
 1141 AAEKVSRTKE FVTDGSMRVL IGTKLVTEGI DIKQLMMVIM LDNRLNIIEL IQGVGRLRDG1200
 1201 GLCYLLSRKN SWAARNRKGE LPPIKEGCIT EQVREFYGLE SKKGKKGQHV GCCGSRTDLS1260
 1261 ADTVELIERM DRLAEKQATA SMSIVALPSS FQESNSSDRC RKYCSSDEDS DTCIHGSANA1320
 1321 STNATTNSST NATTTASTNV RTSATTTASI NVRTSATTTE STNSSTNATT TASTNVRTSA1380
 1381 TTTASINVRT SATTTESTNS NTSATTTEST DSNTSATTTE STDSNTSATT TASTNSSTNA1440
 1441 TTTASTNSST NATTTESTNA SAKEDANKDG NAEDNRFHPV TDINKESYKR KGSQMVLLER1500
 1501 KKLKAQFPNT SENMNVLQFL GFRSDEIKHL FLYGIDVYFC PEGVFTQYGL CKGCQKMFEL1560
 1561 CVCWAGQKVS YRRMAWEALA VERMLRNDEE YKEYLEDIEP YHGDPVGYLK YFSVKRGEIY1620
 1621 SQIQRNYAWY LAITRRRETI SVLDSTRGKQ GSQVFRMSGR QIKELYYKVW SNLRESKTEV1680
 1681 LQYFLNWDEK KCREEWEAKD DTVFVEALEK VGVFQRLRSM TSAGLQGPQY VKLQFSRHHR1740
 1741 QLRSRYELSL GMHLRDQLAL GVTPSKVPHW TAFLSMLIGL FCNKTFRQKL EYLLEQISEV1800
 1801 WLLPHWLDLA NVEVLAADNT RVPLYMLMVA VHKELDSDDV PDGRFDILLC RDSSREVGE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AVT2 HOS4 SIF2 SNT1 TFP1 TRM3 UTP21 YMR155W YRF1-3, YRF1-7 ZDS2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..273] MSA 2.014888 View MSA. No confident structure predictions are available.
    2 View Details [274..571] MSA 1.011892 View MSA. No confident structure predictions are available.
    3 View Details [572..751] deduced N/A No confident structure predictions are available.
    4 View Details [752..1268] PSI-BLAST 160.228787 Initiation factor 4a
    5 View Details [1269..1602] MSA 101.594997 View MSA. No confident structure predictions are available.
    6 View Details [1603..1859] deduced N/A No confident structure predictions are available.
    7 View Details [1303..1526] MSA 10.140997 View MSA. No confident structure predictions are available.
    8 View Details [1527..1766] deduced N/A No confident structure predictions are available.
    9 View Details [1767..1859] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle