YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: SLH1

General Information:
Name(s) found: SLH1 / YGR271W [SGD]
Description(s) found:
Found 19 descriptions.
SHOW ALL
  • Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1967 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: regulation of translation [IGILink to PubMed articleLink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: RNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEYSADSS KSFMIAMQSM IDTSQTFNLD RSKISLPDFD DELKKVQKDE PNQRTELTVL  60
   61 SQDRNDWDDI FEEFKDISFA QLQSIIDSYK TKNAVAVYKK IGKLINEAET TLSSNVLLET 120
  121 VLQMVYKHQK QELEKELLDF LGTGNIDLVS LLLQHRRMIV ATPIETTILL IKNAVNSTPE 180
  181 FLTQQDIRNQ VLESAEDAKN RKLNPATKII KYPHVFRKYE AGSTTAMAFA GQKFTLPVGT 240
  241 TRMSYNTHEE IIIPAADQAS NKNYLYTKLL KISDLDHFCK TVFPYETLNQ IQSLVYPVAY 300
  301 KTNENMLICA PTGAGKTDIA LLTIINTIKQ FSVVNGENEI DIQYDDFKVI YVAPLKALAA 360
  361 EIVDKFSKKL APFNIQVREL TGDMQLTKAE ILATQVIVTT PEKWDVVTRK ANGDNDLVSK 420
  421 VKLLIIDEVH LLHEDRGPVI ETLVARTLRQ VESSQSMIRI IGLSATLPNF MDVADFLGVN 480
  481 RQIGMFYFDQ SFRPKPLEQQ LLGCRGKAGS RQSKENIDKV AYDKLSEMIQ RGYQVMVFVH 540
  541 SRKETVKSAR NFIKLAESNH EVDLFAPDPI EKDKYSRSLV KNRDKDMKEI FQFGFGIHHA 600
  601 GMARSDRNLT EKMFKDGAIK VLCCTATLAW GVNLPADCVI IKGTQVYDSK KGGFIDLGIS 660
  661 DVIQIFGRGG RPGFGSANGT GILCTSNDRL DHYVSLITQQ HPIESRFGSK LVDNLNAEIS 720
  721 LGSVTNVDEA IEWLGYTYMF VRMRKNPFTY GIDWEEIAND PQLYERRRKM IVVAARRLHA 780
  781 LQMIVFDEVS MHFIAKDLGR VSSDFYLLNE SVEIFNQMCD PRATEADVLS MISMSSEFDG 840
  841 IKFREEESKE LKRLSDESVE CQIGSQLDTP QGKANVLLQA YISQTRIFDS ALSSDSNYVA 900
  901 QNSVRICRAL FLIGVNRRWG KFSNVMLNIC KSIEKRLWAF DHPLCQFDLP ENIIRRIRDT 960
  961 KPSMEHLLEL EADELGELVH NKKAGSRLYK ILSRFPKINI EAEIFPITTN VMRIHIALGP1020
 1021 DFVWDSRIHG DAQFFWVFVE ESDKSQILHF EKFILNRRQL NNQHEMDFMI PLSDPLPPQV1080
 1081 VVKVVSDTWI GCESTHAISF QHLIRPFNET LQTKLLKLRP LPTSALQNPL IESIYPFKYF1140
 1141 NPMQTMTFYT LYNTNENAFV GSPTGSGKTI VAELAIWHAF KTFPGKKIVY IAPMKALVRE1200
 1201 RVDDWRKKIT PVTGDKVVEL TGDSLPDPKD VHDATIVITT PEKFDGISRN WQTRKFVQDV1260
 1261 SLIIMDEIHL LASDRGPILE MIVSRMNYIS SQTKQPVRLL GMSTAVSNAY DMAGWLGVKD1320
 1321 HGLYNFPSSV RPVPLKMYID GFPDNLAFCP LMKTMNKPVF MAIKQHSPDK PALIFVASRR1380
 1381 QTRLTALDLI HLCGMEDNPR RFLNIDDEEE LQYYLSQVTD DTLKLSLQFG IGLHHAGLVQ1440
 1441 KDRSISHQLF QKNKIQILIA TSTLAWGVNL PAHLVIIKGT QFFDAKIEGY RDMDLTDILQ1500
 1501 MMGRAGRPAY DTTGTAIVYT KESKKMFYKH FLNVGFPVES SLHKVLDDHL GAEITSGSIT1560
 1561 NKQEALDFLS WTFLFRRAHH NPTYYGIEDD TSTAGVSEHL SSLIDSTLEN LRESQCVLLH1620
 1621 GDDIVATPFL SISSYYYISH LTIRQLLKQI HDHATFQEVL RWLSLAVEYN ELPVRGGEII1680
 1681 MNEEMSQQSR YSVESTFTDE FELPMWDPHV KTFLLLQAHL SRVDLPIADY IQDTVSVLDQ1740
 1741 SLRILQAYID VASELGYFHT VLTMIKMMQC IKQGYWYEDD PVSVLPGLQL RRIKDYTFSE1800
 1801 QGFIEMTPQQ KKKKLLTLEE IGRFGYKKLL NVFDQLTFGM TESEDTKKRF VSVCQRLPVL1860
 1861 EGMKFEEQEN NEVLTFYSKH LSSKHNNGFE VYCDKFPKIQ KELWFLIGHK GDELLMIKRC1920
 1921 QPKQMNKEVI IHCDLFIPEE IRGEELQFSL INDALGLRYD MVHKLIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 identification data - first search in cascade Green EM, et al (2005)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SLH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..255] MSA 10.589997 View MSA. No confident structure predictions are available.
    2 View Details [256..492] PSI-BLAST 80.69897 Putative DEAD box RNA helicase
    3 View Details [493..695] PSI-BLAST 80.69897 Putative DEAD box RNA helicase
    4 View Details [696..789] PSI-BLAST 4.39794 Nucleotide excision repair enzyme UvrB
    5 View Details [790..1074] MSA 1.091995 View MSA. No confident structure predictions are available.
    6 View Details [1075..1270] ORFEUS 14.93 RecG, N-terminal domain; RecG "wedge" domain; RecG helicase domain
    7 View Details [1271..1588] PSI-BLAST 6.0 Nucleotide excision repair enzyme UvrB
    8 View Details [1589..1776] deduced N/A No confident structure predictions are available.
    9 View Details [1777..1856] PSI-BLAST 2.522879 Ribosomal protein L32e
    10 View Details [1857..1967] MSA 1.038994 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
    		• 6.33745214454795 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  2.97534133779092 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  2.96650679245363 bayes_pls_golite062009
  • RNA helicase activity
    		•  2.83814950186361 bayes_pls_golite062009
  • structural molecule activity
    		•  2.81579918518889 bayes_pls_golite062009
  • binding
    		•  2.59063189683655 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.89039798688851 bayes_pls_golite062009
  • helicase activity
    		•  1.52111969749634 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.48276729246798 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.48276729246798 bayes_pls_golite062009
  • protein binding
    		•  1.40069187357924 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.262645824445581 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.0135923951994963 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.0135923951994963 bayes_pls_golite062009
    5
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  3.070470376968 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.11222585187695 bayes_pls_golite062009
  • structural molecule activity
    		•  2.08211451183607 bayes_pls_golite062009
  • DNA binding
    		•  1.7904783386531 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.68903321260301 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • snRNA binding
    		•  1.20045983086701 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • transcription factor activity
    		•  0.603758349693077 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.569910969126728 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.568840867400671 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.568779924702229 bayes_pls_golite062009
  • nucleotide binding
    		•  0.564275755355315 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • ATP binding
    		•  0.1860481660648 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.152859582615242 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.138615225841109 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0530667986761242 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0482442222493492 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.028470639373934 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0265151533232588 bayes_pls_golite062009
    6
    Term Confidence Notes
  • structural molecule activity
    		•  2.80935217964088 bayes_pls_golite062009
  • binding
    		•  2.65544526722793 bayes_pls_golite062009
  • protein binding
    		•  1.50286160643298 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  0.423207248971435 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  0.423207248971435 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.42238661903557 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.
    10 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle