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Protein Overview: YAP1802

General Information:
Name(s) found: YAP1802 / YGR241C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 568 amino acids

    Gene Ontology:
    Cellular Component: actin cortical patch [IDALink to PubMed article]
    Biological Process: endocytosis [IPILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: clathrin binding [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLYTKLVK GATKIKMAPP KQKYVDPILS GTSSARGLQE ITHALDIRLS DTAWTIVYKA  60
   61 LIVLHLMIQQ GEKDVTLRHY SHNLDVFQLR KISHTTKWSS NDMRALQRYD EYLKTRCEEY 120
  121 GRLGMDHLRD NYSSLKLGSK NQLSMDEELD HVESLEIQIN ALIRNKYSVS DLENHLLLYA 180
  181 FQLLVQDLLG LYNALNEGVI TLLESFFELS IEHAKRTLDL YKDFVDMTEY VVRYLKIGKA 240
  241 VGLKIPVIKH ITTKLINSLE EHLREETKRQ RGEPSEPQQD RKPSTAISST SSHNNNSNDK 300
  301 NKSIAQKKLE QIREQKRLLE QQLQNQQLLI SPTVPQDAYN PFGSQQQDLN NDTFSFEPTQ 360
  361 PQMTAQVPQP TANPFLIPQQ QQQALQLTSA STMPQPSEIQ ITPNLNNQQT GMYASNLQYT 420
  421 PNFTGSGFGG YTTTENNAIM TGTLDPTKTG SNNPFSLENI AREQQQQNFQ NSPNPFTLQQ 480
  481 AQTTPILAHS QTGNPFQAQN VVTSPMGTYM TNPVAGQLQY ASTGAQQQPQ MMQGQQTGYV 540
  541 MVPTAFVPIN QQQQQQQHQQ ENPNLIDI

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ENT1 ENT2 PAN1 YAP1801 YAP1802

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GTS1 YAP1802 2 Unpublished Fields Lab Data
    View Screen KAP104 YAP1802 1 Unpublished Fields Lab Data
    View Screen BEM1 YAP1802 1 Unpublished Fields Lab Data
    View Screen NOP6 YAP1802 1 Unpublished Fields Lab Data
    View Screen RAD54 YAP1802 1 Unpublished Fields Lab Data
    View Screen PXR1 YAP1802 1 Unpublished Fields Lab Data
    View Screen RIM11 YAP1802 1 Unpublished Fields Lab Data
    View Screen ARE2 YAP1802 1 Unpublished Fields Lab Data
    View Screen NOG1 YAP1802 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YAP1802 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123]
    [161..186]    		 PSI-BLAST 325.0 Clathrin assembly lymphoid myeloid leukaemia protein, Calm
    2 View Details [124..160]
    [187..284]    		 PSI-BLAST 325.0 Clathrin assembly lymphoid myeloid leukaemia protein, Calm
    3 View Details [285..568] MSA 31.292997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • clathrin binding
    		•  2.70535896247543 bayes_pls_golite062009
  • binding
    		•  2.34501465852339 bayes_pls_golite062009
  • protein binding
    		•  1.7891964555817 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.20269437433936 bayes_pls_golite062009
  • phosphoinositide binding
    		•  0.87586037360588 bayes_pls_golite062009
  • phospholipid binding
    		•  0.84481265656013 bayes_pls_golite062009
  • lipid binding
    		•  0.176990783274449 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle