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Protein Overview: RNR4

General Information:
Name(s) found: RNR4 / YGR180C [SGD]
Description(s) found:
Found 39 descriptions.
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  • Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 345 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    ribonucleoside-diphosphate reductase complex [IDALink to PubMed article][IPILink to PubMed article]
    Biological Process: S phase of mitotic cell cycle [IGILink to PubMed article][IMPLink to PubMed article]
    DNA replication [TASLink to PubMed article]
    Molecular Function: ribonucleoside-diphosphate reductase activity [IDALink to PubMed article][IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEAHNQFLKT FQKERHDMKE AEKDEILLME NSRRFVMFPI KYHEIWAAYK KVEASFWTAE  60
   61 EIELAKDTED FQKLTDDQKT YIGNLLALSI SSDNLVNKYL IENFSAQLQN PEGKSFYGFQ 120
  121 IMMENIYSEV YSMMVDAFFK DPKNIPLFKE IANLPEVKHK AAFIERWISN DDSLYAERLV 180
  181 AFAAKEGIFQ AGNYASMFWL TDKKIMPGLA MANRNICRDR GAYTDFSCLL FAHLRTKPNP 240
  241 KIIEKIITEA VEIEKEYYSN SLPVEKFGMD LKSIHTYIEF VADGLLQGFG NEKYYNAVNP 300
  301 FEFMEDVATA GKTTFFEKKV SDYQKASDMS KSATPSKEIN FDDDF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RNR2 RNR4
    View Details (MIPS) Mewes HW, et al. (2004) RNR1 RNR2 RNR3 RNR4
    View Details Krogan NJ, et al. (2006) RNR1 RNR2 RNR3 RNR4
    View Details Gavin AC, et al. (2006) RNR2 RNR4
    View Details Gavin AC, et al. (2002) ASF1 HIR3 MAM33 RAD53 RNR2 RNR4
    View Details Qiu et al. (2008) RNR1 RNR2 RNR3 RNR4

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #06 Alpha Factor Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data RNR4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..27]
    [153..198]
    [221..345]    		 PSI-BLAST 10096.522879 Ribonucleotide reductase R2
    2 View Details [28..57]
    [89..126]
    [215..220]    		 PSI-BLAST 10096.522879 Ribonucleotide reductase R2
    3 View Details [58..88]
    [127..152]
    [199..214]    		 PSI-BLAST 10096.522879 Ribonucleotide reductase R2

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
    		•  12.7205287868529 bayes_pls_golite062009
  • ribonucleoside-diphosphate reductase activity
    		•  12.6679910771829 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH or CH2 groups
    		•  12.0783326936172 bayes_pls_golite062009
  • class I ribonucleotide reductase activity
    		•  7.27682621818194 bayes_pls_golite062009
  • oxidoreductase activity
    		•  2.7065388366096 bayes_pls_golite062009
  • binding
    		•  2.38747290927526 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.65619019230429 bayes_pls_golite062009
  • DNA binding
    		•  1.60520679245579 bayes_pls_golite062009
  • protein binding
    		•  1.35559475972187 bayes_pls_golite062009
  • ion binding
    		•  0.214820110894452 bayes_pls_golite062009
  • cation binding
    		•  0.203880627974907 bayes_pls_golite062009
  • metal ion binding
    		•  0.203880627974907 bayes_pls_golite062009
  • catalytic activity
    		•  0.197328811494233 bayes_pls_golite062009
  • transition metal ion binding
    		•  0.168785605665701 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle