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Protein Overview: GTR2

General Information:
Name(s) found: GTR2 / YGR163W [SGD]
Description(s) found:
Found 35 descriptions.
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  • Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 341 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    late endosome membrane [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed articleLink to PubMed article]
    vacuolar membrane [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    microautophagy [IMPLink to PubMed article]
    Molecular Function: GTPase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLEATDSKA MVLLMGVRRC GKSSICKVVF HNMQPLDTLY LESTSNPSLE HFSTLIDLAV  60
   61 MELPGQLNYF EPSYDSERLF KSVGALVYVI DSQDEYINAI TNLAMIIEYA YKVNPSINIE 120
  121 VLIHKVDGLS EDFKVDAQRD IMQRTGEELL ELGLDGVQVS FYLTSIFDHS IYEAFSRIVQ 180
  181 KLIPELSFLE NMLDNLIQHS KIEKAFLFDV NSKIYVSTDS NPVDIQMYEV CSEFIDVTID 240
  241 LFDLYKAPVL RNSQKSSDKD NVINPRNELQ NVSQLANGVI IYLRQMIRGL ALVAIIRPNG 300
  301 TDMESCLTVA DYNIDIFKKG LEDIWANARA SQAKNSIEDD V

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) AMN1 ESP1 GTR2 RVB2 SPT16 YCH1 YCR015C
    View Details Qiu et al. (2008) GTR1 GTR2 MEH1 SLM4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GTR2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..220] PSI-BLAST 55.69897 Rab-related protein Sec4
    2 View Details [221..341] MSA 1.226974 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle