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Protein Overview: SKN1

General Information:
Name(s) found: SKN1 / YGR143W [SGD]
Description(s) found:
Found 25 descriptions.
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  • Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 771 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDALink to PubMed article]
    Biological Process: cellular cell wall organization [IMPLink to PubMed article]
    1,6-beta-glucan biosynthetic process [IMPLink to PubMed article][ISSLink to PubMed article]
    sphingolipid biosynthetic process [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: glucosidase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVRNLTNNR HSNSENSVSG SENSFYSSNE QSRQSSSLEP ADGQNVRVSG NPFLGSEEFD  60
   61 EDYNSPSGDD ERRGANEYSS SSSINYNNDP NSDTSLLANE KNSPERNGQR MSDYKGYYAK 120
  121 TNLTSANNLN NHNNNNYKNI ISSSNDNSFA SHLQPPDRNL PSHPSSNNMS SFSNNSLIKS 180
  181 PPPFDRYPLV GTRHISAAQS QSQNLINEKK RANMTGSSSS AHDSSLSSTN LYMGEQDFSP 240
  241 FGGYPASFFP LTLDEKEDDD YIHNPNVEEE AKLDRRRFVD DFKHMDRRSF LGLLGILFLF 300
  301 MAGIFIFIVL PAITFSGVVY HHEHVHAANS AGSSSSNTTS KSLTEYQYPQ LAAIRTTLVD 360
  361 PDTPDSAKTR VAKDGSKWQL VFSDEFNAEG RTFYDGDDQF WTAPDIHYDA TKDLEWYSPD 420
  421 AVTTTNGTLT LRMDAFRNHD LYYRSGMVQS WNKLCFTEGA LEVSANLPNY GRVTGLWPGM 480
  481 WTMGNLGRPG YLASTQGVWP YSYEACDAGI TPNQSSPDGI SYLPGQKLSV CTCDNEDHPN 540
  541 QGVGRGAPEI DILEGEADTI LGVGVASQSL QIAPFDIWYM PDYDFIEVYN FTTTTMNTYA 600
  601 GGPFQQAVSA ISTLNVTWYE FGEEAGYFQK YAIEYLNDDD NGYIRWFVGE NPTFTLYATS 660
  661 LHPSGNIDWR RISKEPMSAI LNLGISNNWA YIDWQYIFFP VTMSIDYVRL YQPKGSTSIT 720
  721 CDPEDYPTYD YIQSHLNAYY NANLTDWEQA GYTFPKNILT GGCSSSKFSL S

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) KRE6 SKN1
    View Details Gavin AC, et al. (2002) BET3 BET5 FKS1 GSG1 KRE11 RVB2 SKN1 TRS120 TRS130 TRS20 TRS23 TRS31 TRS33

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YIF1 SKN1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] ORFEUS 8.05 No description for 1l8mA was found.
    2 View Details [64..142] ORFEUS 8.05 No description for 1l8mA was found.
    3 View Details [143..214] ORFEUS 8.05 No description for 1l8mA was found.
    4 View Details [215..265] ORFEUS 8.05 No description for 1l8mA was found.
    5 View Details [266..474] deduced N/A No confident structure predictions are available.
    6 View Details [475..771] PSI-BLAST 46.30103 Bacillus 1-3,1-4-beta-glucanase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.82375683349763 bayes_pls_golite062009
  • protein binding
    		•  0.964880666937228 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.351620947205387 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.21069016920331 bayes_pls_golite062009
  • DNA binding
    		•  0.0547031308830381 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.0124152418993231 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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