YRC Public Data Repository - Protein Structure Prediction

Protein:	SKN1
Organism:	Saccharomyces cerevisiae
Length:	771 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SKN1.

Description	E-value	Query Range	Subject Range
SKN1_YEAST - Beta-glucan synthesis-associated protein SKN1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288... gi\|190406841 - gi\|190406841\|gb\|EDV10108.1\| beta-glucan synthesis-associated protein SKN1 [Saccharomyces cerevisiae ... SKN1 - Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p	0.0	[1..771]	[1..771]
KRE6_CANAX - Beta-glucan synthesis-associated protein KRE6 OS=Candida albicans GN=KRE6 PE=2 SV=1	0.0	[14..761]	[3..739]
YEPB_SCHPO - Uncharacterized beta-glucan synthesis-associated protein C23H3.11c OS=Schizosaccharomyces pombe (str... SPAC23H3.11c - glucosidase	0.0	[156..765]	[25..629]
gi\|13774093 - gi\|13774093\|gb\|AAK38156.1\| putative beta-glucan synthesis-associated protein [Schizophyllum commune]	7.0E-70	[485..763]	[10..312]
gi\|25398186 - pir\|\|C87296 beta-glucanase [imported] - Caulobacter crescentus gi\|13421537, gi\|... - gi\|16124635\|ref\|NP_419199.1\| beta-glucanase [Caulobacter crescentus CB15], gi\|13421537\|gb\|AAK22367.1... gi\|220962495, gi... - gi\|221233323\|ref\|YP_002515759.1\| glucan endo-1,3-beta-glucosidase [Caulobacter crescentus NA1000], g...	5.0E-58	[375..717]	[23..301]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-56	[373..712]	[422..671]

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Predicted Domain #1

Region A:
Residues: [1-63]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVRNLTNNR HSNSENSVSG SENSFYSSNE QSRQSSSLEP ADGQNVRVSG NPFLGSEEFD  60
   61 EDY

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.05
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #2

Region A:
Residues: [64-142]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSPSGDDERR GANEYSSSSS INYNNDPNSD TSLLANEKNS PERNGQRMSD YKGYYAKTNL  60
   61 TSANNLNNHN NNNYKNIIS

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.05
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #3

Region A:
Residues: [143-214]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSNDNSFASH LQPPDRNLPS HPSSNNMSSF SNNSLIKSPP PFDRYPLVGT RHISAAQSQS  60
   61 QNLINEKKRA NM

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.05
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted Domain #4

Region A:
Residues: [215-265]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGSSSSAHDS SLSSTNLYMG EQDFSPFGGY PASFFPLTLD EKEDDDYIHN P

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	8.05
Match:	1l8mA
Description:	No description for 1l8mA was found.

Predicted functions:

Term	Confidence	Notes
binding	1.82375683349763	bayes_pls_golite062009
protein binding	0.964880666937228	bayes_pls_golite062009
nucleic acid binding	0.351620947205387	bayes_pls_golite062009
transcription regulator activity	0.21069016920331	bayes_pls_golite062009
DNA binding	0.0547031308830381	bayes_pls_golite062009
carbohydrate binding	0.0124152418993231	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [266-474]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVEEEAKLDR RRFVDDFKHM DRRSFLGLLG ILFLFMAGIF IFIVLPAITF SGVVYHHEHV  60
   61 HAANSAGSSS SNTTSKSLTE YQYPQLAAIR TTLVDPDTPD SAKTRVAKDG SKWQLVFSDE 120
  121 FNAEGRTFYD GDDQFWTAPD IHYDATKDLE WYSPDAVTTT NGTLTLRMDA FRNHDLYYRS 180
  181 GMVQSWNKLC FTEGALEVSA NLPNYGRVT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [475-771]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLWPGMWTMG NLGRPGYLAS TQGVWPYSYE ACDAGITPNQ SSPDGISYLP GQKLSVCTCD  60
   61 NEDHPNQGVG RGAPEIDILE GEADTILGVG VASQSLQIAP FDIWYMPDYD FIEVYNFTTT 120
  121 TMNTYAGGPF QQAVSAISTL NVTWYEFGEE AGYFQKYAIE YLNDDDNGYI RWFVGENPTF 180
  181 TLYATSLHPS GNIDWRRISK EPMSAILNLG ISNNWAYIDW QYIFFPVTMS IDYVRLYQPK 240
  241 GSTSITCDPE DYPTYDYIQS HLNAYYNANL TDWEQAGYTF PKNILTGGCS SSKFSLS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	46.30103
Match:	1macA_
Description:	Bacillus 1-3,1-4-beta-glucanase
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: