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Protein Overview: PEX4

General Information:
Name(s) found: PEX4 / YGR133W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 183 amino acids

    Gene Ontology:
    Cellular Component: peroxisome [IDALink to PubMed article]
    Biological Process: protein import into peroxisome matrix [IMPLink to PubMed article]
    protein targeting to peroxisome [IPILink to PubMed article]
    protein polyubiquitination [TASLink to PubMed article]
    peroxisome organization [TASLink to PubMed article]
    protein monoubiquitination [TASLink to PubMed article]
    Molecular Function: ubiquitin-protein ligase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPNFWILENR RSYTSDTCMS RIVKEYKVIL KTLASDDPIA NPYRGIIESL NPIDETDLSK  60
   61 WEAIISGPSD TPYENHQFRI LIEVPSSYPM NPPKISFMQN NILHCNVKSA TGEICLNILK 120
  121 PEEWTPVWDL LHCVHAVWRL LREPVCDSPL DVDIGNIIRC GDMSAYQGIV KYFLAERERI 180
  181 NNH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC13 PEX4 1 Unpublished Fields Lab Data
    View Screen UBC6 PEX4 1 Unpublished Fields Lab Data
    View Screen PEX4 HSM3 1 Unpublished Fields Lab Data
    View Screen PEX4 YCL056C 1 Unpublished Fields Lab Data
    View Screen PEX4 PEX10 1 Unpublished Fields Lab Data
    View Screen PEX4 YPS3 1 Unpublished Fields Lab Data
    View Screen PEX4 PEX13 1 Unpublished Fields Lab Data
    View Screen PEX4 ASR1 1 Unpublished Fields Lab Data
    View Screen SAM35 PEX4 1 Unpublished Fields Lab Data
    View Screen YPR097W PEX4 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PEX4 Huh WK, et al. (2003)
    View Data PEX4 and PEX3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..183] PSI-BLAST 191.373389 Ubiquitin conjugating enzyme, UBC

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • ligase activity
    		•  5.17219147802758 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • HLH domain binding
    		•  2.41376652679018 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  0.715654744941217 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle