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Protein Overview: UBP3

General Information:
Name(s) found: UBP3 / YER151C [SGD]
Description(s) found:
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  • gi|6320999|ref|NP_011078.1| Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not poly [NCBI NR]
  • gi|603391|gb|AAB64678.1| Ubp3p: ubiquitin-specific protease [Saccharomyces cerevisiae] [NCBI NR]
  • gi|401244|sp|Q01477.1|UBP3_YEAST RecName: Full=Ubiquitin carboxyl-terminal hydrolase 3; AltName: Full=Ubiquitin thioesterase 3; AltName: Full=Ubiquitin-specific-processing protease 3; AltName: Full=Deubiquitinating enzyme 3 [NCBI NR]
  • pir||B44450 ubiquitin-specific proteinase (EC 3.4.-.-) UBP3 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|173130|gb|AAA35191.1| ubiquitin-specific processing protease [Saccharomyces cerevisiae] [NCBI NR]
  • Ubiquitin carboxyl-terminal hydrolase 3 OS=Saccharomyces cerevisiae GN=UBP3 PE=1 SV=1 [Swiss-Prot]
  • UBP3 Ubiquitin-specific proteinase [mips]
  • Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin [SGD]
  • UBP3, Chr V from 469681-472419, reverse complement [yeast_orfs2]
  • Chr V from 469681-472419, reverse complement [yeastorf3.fasta]
  • Chr V from 472419-469681, reverse complement [yeastorf5.fasta]
  • (Q01477) Ubiquitin carboxyl-terminal hydrolase 3 (EC 3.1.2.15) (Ubiquitin thiolesterase 3) (Ubiquitin-specific processing protease 3) (Deubiquitinating enzyme 3) [4932.FASTACCERV.txt]
  • UBP3 SGDID:S0000953, Chr V from 472419-469681, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene sillencing; cleaves ubiquitin fusions but not polyubiquitin [Saccharomyces ce [nrdb_11152004_Chlamydomonas]
  • UBP3 SGDID:S000000953, Chr V from 472419-469681, reverse complement, Verified ORF, "Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor o [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ubiquitin-specific processing protease [nr-271106-contam.fasta]
  • Ubp3p: ubiquitin-specific protease [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 3 (Ubiquitin thioesterase 3) (Ubiquitin-specific-processing protease 3) (Deubiquitinating enzyme 3) [nr-271106-contam.fasta]
  • Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; Ubp3p [Saccharomy [nr-271106-contam.fasta]
  • UBP3 SGDID:S000000953, Chr V from 472419-469681, reverse complement, Verified ORF, "Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Ubiquitin carboxyl-terminal hydrolase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP3 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • UBP3 SGDID:S000000953, Chr V from 472424-469686, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity" [yeast-030211-contam.fasta]
  • UBP3 SGDID:S000000953, Chr V from 472424-469686, Genome Release 64-2-1, reverse complement, Verified ORF, "Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress; role in ribophagy" [20141208_orf_trans.fasta]
  • YER151C SGDID:S000000953, Chr V from 472424-469686, Genome Release 64-1-1, reverse complement, Verified ORF, "Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 912 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ICLink to PubMed article]
    Biological Process: protein deubiquitination [TASLink to PubMed article]
    response to drug [IMPLink to PubMed article]
    Molecular Function: ubiquitin-specific protease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNMQDANKEE SYSMYPKTSS PPPPTPTNMQ IPIYQAPLQM YGYTQAPYLY PTQIPAYSFN  60
   61 MVNQNQPIYH QSGSPHHLPP QNNINGGSTT NNNNINKKKW HSNGITNNNG SSGNQGANSS 120
  121 GSGMSYNKSH TYHHNYSNNH IPMMASPNSG SNAGMKKQTN SSNGNGSSAT SPSYSSYNSS 180
  181 SQYDLYKFDV TKLKNLKENS SNLIQLPLFI NTTEAEFAAA SVQRYELNMK ALNLNSESLE 240
  241 NSSVEKSSAH HHTKSHSIPK HNEEVKTETH GEEEDAHDKK PHASKDAHEL KKKTEVKKED 300
  301 AKQDRNEKVI QEPQATVLPV VDKKEPEESV EENTSKTSSP SPSPPAAKSW SAIASDAIKS 360
  361 RQASNKTVSG SMVTKTPISG TTAGVSSTNM AAATIGKSSS PLLSKQPQKK DKKYVPPSTK 420
  421 GIEPLGSIAL RMCFDPDFIS YVLRNKDVEN KIPVHSIIPR GIINRANICF MSSVLQVLLY 480
  481 CKPFIDVINV LSTRNTNSRV GTSSCKLLDA CLTMYKQFDK ETYEKKFLEN ADDAEKTTES 540
  541 DAKKSSKSKS FQHCATADAV KPDEFYKTLS TIPKFKDLQW GHQEDAEEFL THLLDQLHEE 600
  601 LISAIDGLTD NEIQNMLQSI NDEQLKVFFI RNLSRYGKAE FIKNASPRLK ELIEKYGVIN 660
  661 DDSTEENGWH EVSGSSKRGK KTKTAAKRTV EIVPSPISKL FGGQFRSVLD IPNNKESQSI 720
  721 TLDPFQTIQL DISDAGVNDL ETAFKKFSEY ELLPFKSSSG NDVEAKKQTF IDKLPQVLLI 780
  781 QFKRFSFINN VNKDNAMTNY NAYNGRIEKI RKKIKYGHEL IIPEESMSSI TLKNNTSGID 840
  841 DRRYKLTGVI YHHGVSSDGG HYTADVYHSE HNKWYRIDDV NITELEDDDV LKGGEEASDS 900
  901 RTAYILMYQK RN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRE5 UBP3
    View Details Krogan NJ, et al. (2006) TIP1 UBP3
    View Details Gavin AC, et al. (2006) BRE5 UBP3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run VAM3 hx23: mixture in detergent (control) Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex Hao Xu, et al. (2010)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CTF8 UBP3 2 Unpublished Fields Lab Data
    View Screen CDC13 UBP3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data UBP3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..253] ORFEUS 14.84 RBP1
    2 View Details [254..416] ORFEUS 15.0 No description for 1ldvA was found.
    3 View Details [417..499] Pfam 9.79588 No description for PF00442 was found. No confident structure predictions are available.
    4 View Details [500..575] deduced N/A No confident structure predictions are available.
    5 View Details [576..812] MSA 4.22699 View MSA. No confident structure predictions are available.
    6 View Details [813..912] Pfam 24.267606 Ubiquitin carboxyl-terminal hydrolase No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle