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Protein Overview: SCC4

General Information:
Name(s) found: SCC4 / YER147C [SGD]
Description(s) found:
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  • gi|731524|sp|P40090.1|SCC4_YEAST RecName: Full=Sister chromatid cohesion protein 4 [NCBI NR]
  • gi|6320995|ref|NP_011074.1| Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated [NCBI NR]
  • gi|603387|gb|AAB64674.1| Yer147cp [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S50650 hypothetical protein YER147c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Sister chromatid cohesion protein 4 OS=Saccharomyces cerevisiae GN=SCC4 PE=1 SV=1 [Swiss-Prot]
  • SCC4 Protein required for sister chromatid cohesion [mips]
  • Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX [SGD]
  • SCC4, Chr V from 462963-464837, reverse complement [yeast_orfs2]
  • Chr V from 462963-464837, reverse complement [yeastorf3.fasta]
  • Chr V from 464837-462963, reverse complement [yeastorf5.fasta]
  • (P40090) Sister chromatid cohesion protein 4 [4932.FASTACCERV.txt]
  • SCC4 SGDID:S0000949, Chr V from 464837-462963, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Scc4p [Saccharomyces cerevisiae]gi|731524|sp|P40090|SCC4_YEAST Sister chromatid cohesion protein 4gi|1077715|pir||S50650 hypothetical protein YER147c - yeast (Saccharomyces cerevisiae)gi|603387|gb|AAB64674.1| Yer147cp [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • SCC4 SGDID:S000000949, Chr V from 464837-462963, reverse complement, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesi [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Yer147cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Sister chromatid cohesion protein 4 [nr-271106-contam.fasta]
  • Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX; Scc4p [Sacchar [nr-271106-contam.fasta]
  • SCC4 SGDID:S000000949, Chr V from 464837-462963, reverse complement, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • MAU2 chromatid cohesion factor homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SCC4 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SCC4 SGDID:S000000949, Chr V from 464842-462968, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX" [yeast-030211-contam.fasta]
  • SCC4 SGDID:S000000949, Chr V from 464842-462968, Genome Release 64-2-1, reverse complement, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p); complex is required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX" [20141208_orf_trans.fasta]
  • YER147C SGDID:S000000949, Chr V from 464842-462968, Genome Release 64-1-1, reverse complement, Verified ORF, "Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 624 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [IDALink to PubMed article]
    Biological Process: sister chromatid cohesion [IMPLink to PubMed article]
    double-strand break repair via homologous recombination [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENLGDKLSI SQVYHLAQEY RDHAYSIANK IGSEEGLKQY YGLMNMSIQM FQLLKTKCTL  60
   61 SVLEDSKVTF EMVELLIQET YNFDLAELYI SSLKERLQTH QSDTDLVEEI MRCEFLLLHD 120
  121 LPLMRDSKFH YKIALRNCNE LVQYMVNLQD ELYQNWASVF QYVGVMLCIK LKQHRRVKTS 180
  181 FHGLLSQCRE KSQWKWFLNL CYVNYLLNER FPIPEDALQE LRSTELHTVG PELYAWKLAL 240
  241 EMVIQLCKDG NITDHLNEFK NFFDTNKQSL VTNEGKGCVI KIMPRIALKV ELPMIFHYKE 300
  301 LKNILLLLQS VSYIVNCYDE KGNFSRKFLP KVYSTTQKLI KNIAAGGVSM NELDSRIQTY 360
  361 KSILEFCEFY KVWEQTLLKG AVVTTESPKL GPSPGYVRLL QAMKVQFEGG GAVEEYTRLA 420
  421 QSGGTSSEVK MISLLNCYTV QAARVSRCSG DKQGELVEQC NKVWLQVEKL LQETDLQFNP 480
  481 IWECTVTILW LFSHFEPFSW NPLPCSDKQR AEYVSKLREF YSSNKFVAGE AVADNRFKLK 540
  541 KALLLQILVN YLGGRMLEHD LGEIYAISAK CFDMCRQQGG MRKVQYVIGI WHLMNCTVAM 600
  601 RGKDVALTNA KLEALVKQIT SVKQ

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MDJ1 SCC2 SCC4
    View Details Gavin AC, et al. (2002) CCT8 GCN1 HHF1, HHF2 IRR1 KAP123 MCD1 NOP12 RVB2 SCC4 SMC1 SMC3 YHB1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SCC4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [102..272] deduced N/A No confident structure predictions are available.
    3 View Details [273..503] deduced N/A No confident structure predictions are available.
    4 View Details [504..624] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle