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Protein Overview: CUP5

General Information:
Name(s) found: CUP5 / YEL027W [SGD]
Description(s) found:
Found 32 descriptions.
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  • Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 160 amino acids

    Gene Ontology:
    Cellular Component: vacuolar proton-transporting V-type ATPase, V0 domain [TASLink to PubMed articleLink to PubMed article]
    integral to membrane [IDALink to PubMed article]
    Biological Process: cellular iron ion homeostasis [IMPLink to PubMed article]
    cellular copper ion homeostasis [IMPLink to PubMed article]
    proton transport [TASLink to PubMed article]
    vacuole organization [IMPLink to PubMed article]
    vacuolar acidification [TASLink to PubMed articleLink to PubMed article]
    endocytosis [IMPLink to PubMed article]
    protein targeting to vacuole [IMPLink to PubMed article]
    Molecular Function: hydrogen ion transmembrane transporter activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTELCPVYAP FFGAIGCASA IIFTSLGAAY GTAKSGVGIC ATCVLRPDLL FKNIVPVIMA  60
   61 GIIAIYGLVV SVLVCYSLGQ KQALYTGFIQ LGAGLSVGLS GLAAGFAIGI VGDAGVRGSS 120
  121 QQPRLFVGMI LILIFAEVLG LYGLIVALLL NSRATQDVVC

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA13 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VPH1
    View Details Qiu et al. (2008) CUP5 PPA1 STV1 TFP1 TFP3 VMA10 VMA2 VMA4 VMA5 VMA6 VMA7 VMA8 VMA9 VPH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CUP5 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..81] Pfam 20.318759 ATP synthase subunit C No confident structure predictions are available.
    2 View Details [82..160] Pfam 20.769551 ATP synthase subunit C No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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