Protein Overview: URA3

General Information:
Name(s) found:	URA3 / YEL021W [SGD]
Description(s) found: Found 36 descriptions. SHOW ALL	Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound [SGD]
Organism:	Saccharomyces cerevisiae
Length:	267 amino acids
Gene Ontology:
Cellular Component:	cytosol [ISS]
Biological Process:	'de novo' pyrimidine base biosynthetic process [TAS] pyrimidine base biosynthetic process [TAS]
Molecular Function:	orotidine-5'-phosphate decarboxylase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKATYKERA ATHPSPVAAK LFNIMHEKQT NLCASLDVRT TKELLELVEA LGPKICLLKT  60
   61 HVDILTDFSM EGTVKPLKAL SAKYNFLLFE DRKFADIGNT VKLQYSAGVY RIAEWADITN 120
  121 AHGVVGPGIV SGLKQAAEEV TKEPRGLLML AELSCKGSLA TGEYTKGTVD IAKSDKDFVI 180
  181 GFIAQRDMGG RDEGYDWLIM TPGVGLDDKG DALGQQYRTV DDVVSTGSDI IIVGRGLFAK 240
  241 GRDAKVEGER YRKAGWEAYL RRCGQQN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		NAS6 RPN1 RPN2 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT5 UBP6 URA3
View Details	Krogan NJ, et al. (2006)		FOL1 URA3 YMR074C
View Details	Ho Y, et al. (2002)		RNQ1 URA3

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	URA3	URA3	2	Uetz P, et al. (2000)
View Screen	TEL1	URA3	1	Unpublished Fields Lab Data
View Screen	RHO2	URA3	1	Unpublished Fields Lab Data
View Screen	APC5	URA3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..267]	PSI-BLAST	1607.522879	Orotidine 5'-monophosphate decarboxylase (OMP decarboxylase)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
orotidine-5'-phosphate decarboxylase activity	2.87717797280068	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
binding	1.26628194990205	bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity	0.982517927791965	bayes_pls_golite062009
carboxy-lyase activity	0.83446736141993	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	0.700596444201789	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	0.644387926981014	bayes_pls_golite062009
tryptophan synthase activity	0.580372404365274	bayes_pls_golite062009
carbon-carbon lyase activity	0.54291459543716	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.108467338662618	bayes_pls_golite062009
protein binding	0.014429239696785	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2