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Protein Overview: FOL1

General Information:
Name(s) found: FOL1 / YNL256W [SGD]
Description(s) found:
Found 17 descriptions.
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  • Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 824 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mitochondrial envelope [IDALink to PubMed article]
    Biological Process: folic acid and derivative biosynthetic process [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity [IDALink to PubMed article][ISSLink to PubMed article]
    dihydroneopterin aldolase activity [IDALink to PubMed article][ISSLink to PubMed article]
    dihydropteroate synthase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKLFSTVNS ARHSVPLGGM RDYVHIKKLE MNTVLGPDSW NQLMPQKCLL SLDMGTDFSK  60
   61 SAATDDLKYS LNYAVISRDL TNFVSKKKNW GSVSNLAKSV SQFVMDKYSG VECLNLEVQA 120
  121 DTTHIRSDHI SCIIQQERGN PESQEFDVVR ISELKMLTLI GVFTFERLKK QYVTLDIKLP 180
  181 WPKKAELPPP VQSIIDNVVK FVEESNFKTV EALVESVSAV IAHNEYFQKF PDSPLVVKVL 240
  241 KLNAITATEG VGVSCIREPR EIAMVNIPYL SSIHESSDIK FQLSSSQNTP IEGKNTWKRA 300
  301 FLAFGSNIGD RFKHIQMALQ LLSREKTVKL RNISSIFESE PMYFKDQTPF MNGCVEVETL 360
  361 LTPSELLKLC KKIEYEELQR VKHFDNGPRT IDLDIVMFLN SAGEDIIVNE PDLNIPHPRM 420
  421 LERTFVLEPL CELISPVHLH PVTAEPIVDH LKQLYDKQHD EDTLWKLVPL PYRSGVEPRF 480
  481 LKFKTATKLD EFTGETNRIT VSPTYIMAIF NATPDSFSDG GEHFADIESQ LNDIIKLCKD 540
  541 ALYLHESVII DVGGCSTRPN SIQASEEEEI RRSIPLIKAI RESTELPQDK VILSIDTYRS 600
  601 NVAKEAIKVG VDIINDISGG LFDSNMFAVI AENPEICYIL SHTRGDISTM NRLAHYENFA 660
  661 LGDSIQQEFV HNTDIQQLDD LKDKTVLIRN VGQEIGERYI KAIDNGVKRW QILIDPGLGF 720
  721 AKTWKQNLQI IRHIPILKNY SFTMNSNNSQ VYVNLRNMPV LLGPSRKKFI GHITKDVDAK 780
  781 QRDFATGAVV ASCIGFGSDM VRVHDVKNCS KSIKLADAIY KGLE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) FOL1 SSE1
    View Details Krogan NJ, et al. (2006) FOL1 URA3 YMR074C

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FOL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 33.39794 Crystal structure of 7,8-dihydroneopterin aldolase in complex with guanine
    2 View Details [141..295] PSI-BLAST 62.69897 No description for 2cg8A was found.
    3 View Details [296..824] PSI-BLAST 171.0 X-ray structure of the bifunctional 6-hydroxymethyl-7,8- dihydroxypterin pyrophosphokinase dihydropteroate synthase from Sacchromyces cerevisiae

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • GTP cyclohydrolase I activity
    		•  4.1430878480831 bayes_pls_golite062009
  • cyclohydrolase activity
    		•  3.66553359909123 bayes_pls_golite062009
  • GTP cyclohydrolase activity
    		•  3.44912994722205 bayes_pls_golite062009
  • 6-pyruvoyltetrahydropterin synthase activity
    		•  2.77658228107642 bayes_pls_golite062009
  • dihydroneopterin aldolase activity
    		•  2.51107306055654 bayes_pls_golite062009
  • catalytic activity
    		•  2.20788162511962 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.73101699306211 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  0.974891318710762 bayes_pls_golite062009
  • binding
    		•  0.641976427105342 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.0783540825826956 bayes_pls_golite062009
  • protein binding
    		•  0.045916344848404 bayes_pls_golite062009
  • urate oxidase activity
    		•  0.0294957696532921 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle